Systems and methods for file replication using file content location identifiers. An example method may comprise: receiving an identifier of a data structure associated with a file residing on a first file server, the data structure referencing a physical location of the contents of the file; identifying a file system operation to be performed with respect to a replica of the file residing on a second file server; and performing the file system operation by accessing the replica of the file using a file name alias comprising the identifier of the data structure.