A drug delivery device 10 has a support structure 20 and a medicine-laden member 100 affixed or otherwise attached to the support structure 20. The device 10 is sized to fit into the mouth and upon exposing the medicine-laden member 100 to saliva, medicaments 101 are released into the mouth. The drug delivery device 10 permits a new method of medication delivery. The method of oral transmucosal drug delivery has the steps of providing a drug delivery device 10 that fits into the mouth, the device 10 having a medicine-laden member 100; wearing the drug delivery device 10; activating release of medicine 101 by contact with saliva; and transmitting the released medicine 101 transmucosally to the bloodstream.