Invention Grant
- Patent Title: Direct reprogramming of cells to cardiac myocyte fate
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Application No.: US13808311Application Date: 2011-07-08
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Publication No.: US09987309B2Publication Date: 2018-06-05
- Inventor: Victor J. Dzau , Maria Mirotsou , Tilanthi Jayawardena
- Applicant: Victor J. Dzau , Maria Mirotsou , Tilanthi Jayawardena
- Applicant Address: US NC Durham
- Assignee: DUKE UNIVERSITY
- Current Assignee: DUKE UNIVERSITY
- Current Assignee Address: US NC Durham
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo P.C.
- International Application: PCT/US2011/043438 WO 20110708
- International Announcement: WO2012/006577 WO 20120112
- Main IPC: A61K31/7105
- IPC: A61K31/7105 ; C12N15/113 ; C12N5/07 ; A61K35/33 ; A61L27/38 ; A61L27/54 ; A61L29/16 ; A61L31/16 ; C12N5/077
Abstract:
A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.
Public/Granted literature
- US20140011281A1 Direct Reprogramming of Cells to Cardiac Myocyte Fate Public/Granted day:2014-01-09
Information query
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