Invention Grant
- Patent Title: Compositions and methods of using chondroitinase ABCI mutants
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Application No.: US15230040Application Date: 2016-08-05
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Publication No.: US09987340B2Publication Date: 2018-06-05
- Inventor: Anthony O. Caggiano , Andrea Vecchione , Jennifer Iaci
- Applicant: ACORDA THERAPEUTICS, INC.
- Applicant Address: US NY Ardsley
- Assignee: Acorda Therapeutics, Inc.
- Current Assignee: Acorda Therapeutics, Inc.
- Current Assignee Address: US NY Ardsley
- Agency: Pepper Hamilton LLP
- Main IPC: C12N9/88
- IPC: C12N9/88 ; C12N9/20 ; C12N9/24 ; C12N9/14 ; C12N15/64 ; C12P19/34 ; C12P21/06 ; C07H21/04 ; C07K1/00 ; A61M37/00 ; A61K38/00 ; A61K38/46 ; A61K38/51
Abstract:
The present disclosure relates to protein and nucleic acid mutants of chondroitinase ABCI. Such nucleic acid mutants encode for chondroitinase ABCI mutant enzymes exhibiting altered chondroitin lyase activity or increased resistance to inactivation from stressors including UV light or heat. Methods of using such nucleic acid mutants encoding chondroitinase ABCI mutant enzymes is also provided.
Public/Granted literature
- US20170028038A1 COMPOSITIONS AND METHODS OF USING CHONDROITINASE ABCI MUTANTS Public/Granted day:2017-02-02
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