Invention Grant
- Patent Title: Cytotoxic agents for conjugation to a cell binding molecule
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Application No.: US14914739Application Date: 2013-09-02
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Publication No.: US09988408B2Publication Date: 2018-06-05
- Inventor: Robert Yongxin Zhao
- Applicant: Hangzhou DAC Biotech Co., Ltd.
- Applicant Address: CN Hangzhou
- Assignee: HANGZHOU DAC BIOTECH CO., LTD.
- Current Assignee: HANGZHOU DAC BIOTECH CO., LTD.
- Current Assignee Address: CN Hangzhou
- Agency: Buchanan Ingersoll & Rooney PC
- International Application: PCT/IB2013/058229 WO 20130902
- International Announcement: WO2015/028850 WO 20150305
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D519/00 ; C07F9/6561 ; C07F9/553 ; C07F9/6558 ; A61K31/675 ; A61K39/395 ; A61K45/06 ; C07K16/28 ; A61K47/55 ; A61K47/68
Abstract:
The present invention is related to novel cytotoxic agents, pyrrolo[2,1-c][1,4]benzodiazepine (PBD) derivatives, their conjugates with a cell-binding agent, the preparation and the therapeutic uses in the targeted treatment of cancers, autoimmune disorders, and infectious diseases.
Public/Granted literature
- US20160207949A1 NOVEL CYTOTOXIC AGENTS FOR CONJUGATION TO A CELL BINDING MOLECULE Public/Granted day:2016-07-21
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