Invention Grant
- Patent Title: Broad spectrum conjugate vaccine to prevent Klebsiella pneumoniae and Pseudomonas aeruginosa infections
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Application No.: US15509041Application Date: 2015-09-18
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Publication No.: US09988426B2Publication Date: 2018-06-05
- Inventor: Raphael Simon , Alan Cross , Sharon Tennant
- Applicant: Raphael Simon , Alan Cross , Sharon Tennant
- Applicant Address: US MD Baltimore
- Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
- Current Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
- Current Assignee Address: US MD Baltimore
- Agency: Nevrivy Patent Law Group P.L.L.C.
- International Application: PCT/US2015/051032 WO 20150918
- International Announcement: WO2016/044773 WO 20160324
- Main IPC: C07K14/21
- IPC: C07K14/21 ; C07K14/26 ; A61K39/104 ; A61K39/108 ; A61K47/48 ; A61K39/00
Abstract:
The present invention is drawn to conjugates and vaccine compositions comprising a Pseudomonas flagellin or an antigenic fragment or derivative thereof linked to one or more Klebsiella surface polysaccharide antigens, such as Klebsiella pneumoniae O polysaccharide from serovars O1, O2a, O2a,c, O3, O4, O5, O7, O8 and 012. The present invention also provides serovar reagent strains to produce the conjugates and vaccine compositions and methods of inducing an immune response with the conjugates and vaccine compositions.
Public/Granted literature
- US20170260240A1 BROAD SPECTRUM CONJUGATE VACCINE TO PREVENT KLEBSIELLA PNEUMONIAE AND PSEUDOMONAS AERUGINOSA INFECTIONS Public/Granted day:2017-09-14
Information query
