Invention Grant
- Patent Title: Generation of airway and lung progenitors and epithelial cells and three-dimensional anterior foregut spheres
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Application No.: US14417273Application Date: 2013-07-24
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Publication No.: US09988606B2Publication Date: 2018-06-05
- Inventor: Hans-Willem Snoeck , Sarah Xuelian Huang , Ya-Wen Chen , Jahar Bhattacharya , Mohammad Naeem Islam
- Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Applicant Address: US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee Address: US NY New York
- Agency: Leason Ellis LLP
- International Application: PCT/US2013/051913 WO 20130724
- International Announcement: WO2014/018691 WO 20140130
- Main IPC: C12N5/071
- IPC: C12N5/071 ; G01N33/68 ; G01N33/50
Abstract:
Embodiments of the present invention are directed to various methods for generating airway and lung progenitors and epithelial cells and three-dimensional anterior foregut spheres, and to populations of cells made using the methods. The airway and lung progenitors and epithelial cells can be used as a model to study diseases that primarily affect airway epithelial cells, and to study human lung development. Methods are also provided for drug screening. Anterior foregut spheres can be used as a model for lung fibrosis.
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