Invention Grant
- Patent Title: DNA polymerases with increased 3′-mismatch discrimination
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Application No.: US15214323Application Date: 2016-07-19
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Publication No.: US09988613B2Publication Date: 2018-06-05
- Inventor: Fred Reichert , Keith Bauer , Thomas W. Myers , Nancy J. Schoenbrunner , Joseph San Filippo
- Applicant: Roche Molecular Systems, Inc.
- Applicant Address: US CA Pleasanton
- Assignee: Roche Molecular Systems, Inc.
- Current Assignee: Roche Molecular Systems, Inc.
- Current Assignee Address: US CA Pleasanton
- Agency: Kilpatrick Townsend & Stockton LLP
- Main IPC: C12N9/00
- IPC: C12N9/00 ; C12N9/12 ; C12P19/34 ; C12Q1/68

Abstract:
Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.
Public/Granted literature
- US20160319255A1 DNA POLYMERASES WITH INCREASED 3'-MISMATCH DISCRIMINATION Public/Granted day:2016-11-03
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