Invention Grant
- Patent Title: Non-natural amino acid tRNA synthetases for pyridyl tetrazine
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Application No.: US15028379Application Date: 2014-10-10
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Publication No.: US09988619B2Publication Date: 2018-06-05
- Inventor: Erik S. Zimmerman , Christopher Thanos
- Applicant: SUTRO BIOPHARMA, INC.
- Applicant Address: US CA South San Francisco
- Assignee: SUTRO BIOPHARMA, INC.
- Current Assignee: SUTRO BIOPHARMA, INC.
- Current Assignee Address: US CA South San Francisco
- Agency: Kilpatrick Townsend & Stockton LLP
- International Application: PCT/US2014/060061 WO 20141010
- International Announcement: WO2015/054590 WO 20150416
- Main IPC: C07K14/00
- IPC: C07K14/00 ; C07D213/55 ; C12N9/52 ; C12N9/00 ; C12P21/02
Abstract:
The invention provides methods and compositions for a mutein aminoacyl-tRNA synthetase that preferentially charges a tRNA with a non-natural amino acid. Also provided are methods for incorporating the non-natural amino acids, pyridinyl-amino tetrazine amino acids, into a protein, and further conjugating a biologically active adduct to the pyridinyl-amino tetrazine.
Public/Granted literature
- US20160257945A1 NON-NATURAL AMINO ACID tRNA SYNTHETASES FOR PYRIDYL TETRAZINE Public/Granted day:2016-09-08
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