Invention Grant
- Patent Title: Neurocalcin delta inhibitors and therapeutic and non-therapeutic uses thereof
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Application No.: US14908162Application Date: 2014-07-29
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Publication No.: US09988626B2Publication Date: 2018-06-05
- Inventor: Brunhilde Wirth , Markus Riessland
- Applicant: Universität Zu Köln
- Applicant Address: DE Köln
- Assignee: Universität Zu Köln
- Current Assignee: Universität Zu Köln
- Current Assignee Address: DE Köln
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Agent Ingrid A. Beattie
- International Application: PCT/EP2014/066276 WO 20140729
- International Announcement: WO2015/014838 WO 20150205
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C12N15/113 ; A61K31/713 ; A61K35/30 ; A61K45/06 ; C12N5/0793
Abstract:
The present invention relates to an inhibitor of neurocalcin delta (NCALD) for use in a method for the treatment or prevention of a patient suffering from a disorder associated with a pathological calcium homeostasis. Furthermore, the present invention refers to the use of such inhibitor of NCALD for inducing axon proliferation in vitro and to a method for the differentiation and/or maturation of neuronal stem cells (NSCs) in vitro and to the use of such inhibitor of NCALD to restore impaired endocytosis being a consequence of disturbed Ca2+ homeostasis in synaptic terminals essential for development, maturation and maintenance of synapses and neuromuscular junctions (NMJs).
Public/Granted literature
- US20160208248A1 Neurocalcin Delta Inhibitors and Therapeutic and Non-Therapeutic Uses Thereof Public/Granted day:2016-07-21
Information query
