Invention Grant
- Patent Title: Pharmaceutical composition comprising Nanog shRNA, and method of using Nanog shRNA to treat cancer
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Application No.: US15334666Application Date: 2016-10-26
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Publication No.: US09988631B2Publication Date: 2018-06-05
- Inventor: John Milburn Jessup , Nikolay Korokhov
- Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human Services
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Dept. of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Dept. of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Sheridan Ross P.C.
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; C12N15/113 ; C12N15/86
Abstract:
The present description relates to an inhibitory RNA molecule, comprising an oligonucleotide that selectively knocks down expression a Nanog pseudogene expressed in many human cancers, a replicating viral vector capable of encoding such inhibitory RNA molecule, pharmaceutical compositions comprising said vector, and methods of treating cancer by administration of said pharmaceutical composition.
Public/Granted literature
- US20170037406A1 PHARMACEUTICAL COMPOSITION COMPRISING NANOG SHRNA, AND METHOD OF USING NANOG SHRNA TO TREAT CANCER Public/Granted day:2017-02-09
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