A disc brake, in particular for a motor vehicle, has a brake application device, preferably with a brake rotary lever, at least one spindle unit having at least one threaded tube with an external thread that cooperates with an internal thread of a bridge, and at least one bidirectional wear adjustment device which is coupled to the brake application device, preferably to the brake rotary lever. The bidirectional wear adjustment device has an adjustment arrangement and at least one preloading arrangement which is designed to influence a flank position of a thread pairing of the external thread of the at least one threaded tube and the associated internal thread of the bridge.