An integrated circuit (IC) is disclosed herein for adaptive power multiplexing with a power distribution network. In an example aspect, the integrated circuit includes a first power rail, a second power rail, and a load power rail. The integrated circuit also includes multiple power-multiplexer tiles and power-multiplexer control circuitry. The multiple power-multiplexer tiles are coupled in series in a chained arrangement and configured to jointly perform a power-multiplexing operation. Each power-multiplexer tile is configured to switch between coupling the load power rail to the first power rail and coupling the load power rail to the second power rail. The power-multiplexer control circuitry is configured to control a direction of current flow to prevent cross-conduction between the first power rail and the second power rail during the power-multiplexing operation.