A direct-axis current protection method and device for a permanent magnet synchronous motor drive system. The method includes: pre-calculating the direct-axis current of the next moment according to the current voltage transmitted from an inverter to a permanent magnet synchronous motor (PMSM); comparing the direct-axis current of the next moment with a maximum protection current; if the direct-axis current of the next moment is less than the maximum protection current, continuing transmitting the current voltage to the PMSM; if the direct axis current of the next moment is greater than or equal to the maximum protection current, redistributing the voltage according to a protection direct-axis current and a protection quadrature-axis current, and transmitting the redistributed voltage to the PMSM. The direct-axis current of the next moment is tended to be normal by adjusting the voltage.