Invention Application
WO2007015280A8 BENZODIAZEPINE DERIVATIVES AND USES THEREOF IN MEDICAL FIELD
审中-公开
苯并噻吩衍生物及其在医学领域中的应用
- Patent Title: BENZODIAZEPINE DERIVATIVES AND USES THEREOF IN MEDICAL FIELD
- Patent Title (中): 苯并噻吩衍生物及其在医学领域中的应用
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Application No.: PCT/IT2006000401Application Date: 2006-05-26
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Publication No.: WO2007015280A8Publication Date: 2008-04-10
- Inventor: SILVESTRI ROMANO , MARFE GABRIELLA , ABRUZZESE ELISABETTA , CATALANO GIANFRANCO , DI STEFANO CARLA , NOVELLINO ETTORE , SINIBALDI SALIMEI PAOLA , DE MARTINO MARIA GABRIELLA , LA REGINA GIUSEPPE , LAVECCHIA ANTONIO
- Applicant: UNIV ROMA , SILVESTRI ROMANO , MARFE GABRIELLA , ABRUZZESE ELISABETTA , CATALANO GIANFRANCO , DI STEFANO CARLA , NOVELLINO ETTORE , SINIBALDI SALIMEI PAOLA , DE MARTINO MARIA GABRIELLA , LA REGINA GIUSEPPE , LAVECCHIA ANTONIO
- Assignee: UNIV ROMA,SILVESTRI ROMANO,MARFE GABRIELLA,ABRUZZESE ELISABETTA,CATALANO GIANFRANCO,DI STEFANO CARLA,NOVELLINO ETTORE,SINIBALDI SALIMEI PAOLA,DE MARTINO MARIA GABRIELLA,LA REGINA GIUSEPPE,LAVECCHIA ANTONIO
- Current Assignee: UNIV ROMA,SILVESTRI ROMANO,MARFE GABRIELLA,ABRUZZESE ELISABETTA,CATALANO GIANFRANCO,DI STEFANO CARLA,NOVELLINO ETTORE,SINIBALDI SALIMEI PAOLA,DE MARTINO MARIA GABRIELLA,LA REGINA GIUSEPPE,LAVECCHIA ANTONIO
- Priority: ITRM20050416 2005-08-03
- Main IPC: C07D513/04
- IPC: C07D513/04 ; A61K31/55 ; A61P35/02 ; C07D487/04
Abstract:
The invention concerns benzodiazepine derivatives of formula (I) wherein Y it is SO 2 or NR, wherein R is H or C 1 -C 6 alkyl; X is H, C 1 -C 12 alkyl, -CO, -SO, -SO 2 , or - CO-R 2 , SO-R 2 , SO 2 - R 2 , wherein R 2 is selected from H, C 1 -C 12 alkyl, (C 3 -C 8 cycloalkyl) C 0 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C2-C 6 alkoxycarbonyl, phenyl, benzyl, naphtyl, biphenyl, or heterocycle, each para-, meta- or ortho-substituted independently of each other with 0 to 3 substituents selected from halogen, -CN, -NH 2 , -OH, -NO 2 , COOR 3 , wherein R 3 is selected from H, C 1 -C 12 alkyl, (C 3 -C 8 cycloalkyl) C 0 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, or C 2 -C 6 alkoxy carbonyl; phenyl, benzyl, naphtyl, biphenyl, or heterocycle, n is 0-6; R 4 is selected from H, OH, COOH, CN, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 2 -C 6 alkoxycarbonyl, -CO, -SO, - SO 2 , or -CO-R 5 , SO-R 5 , SO 2 -R 2 , -OCO-R 5 , OSO-R 5 , OSO 2 -R 5 , COOR 5 , SOOR 5 , SO 2 OR 5 , NHR 5 , NHCOR 5 , NHSO 2 R 5 , SR 5 , SCOR 5 , wherein R 5 is selected from H, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, or C 2 -C 6 alkoxycarbonyl, phenyl, benzyl, naphtyl, biphenyl, or heterocycle, each para-, meta- or ortho-substituted independently of each other with O to 3 substituents selected from halogen, -CN, -NH 2 , -OH, -NO 2 , COOR 5' , wherein R 5 is selected from H, C 1 -C 12 alkyl, (C 3 -C 8 cycloalkyl) C 0 -C 6 alkyl, phenyl, benzyl, naphtyl, biphenyl, or heterocycle, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, or C 2 -C 6 alkoxy carbonyl; R 6 and R 7 independently of each other are selected from the group consisting of H, OH, halogen, CN, NH 2 , NO 2 , COOR 3 , C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, and C 2 -C 6 alkoxy carbonyl; R 3 is H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl or physiologically acceptable salts and uses thereof in medical field, particularly as anti-tumoral agents.
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