公开(公告)号：WO2012032531A1

公开(公告)日：2012-03-15

申请号：PCT/IN2010/000754

申请日：2010-11-19

Applicant: AVRA LABORATORIES PVT. LTD. ,  ALLA, Venkata, Rama, Rao ,  RAO, Ramakrishna ,  RAMARAO, Chandrashekar ,  NANDIPATI, Ramadevi ,  CHAMLE, Vinay, Avinash

Inventor： ALLA, Venkata, Rama, Rao ,  RAO, Ramakrishna ,  RAMARAO, Chandrashekar ,  NANDIPATI, Ramadevi ,  CHAMLE, Vinay, Avinash

IPC: A01N43/42

CPC classification number: C07D491/22

Abstract: Disclosed herein is a highly safe and easily scalable process for the production of 7-Ethyl- 10-hydroxycamptothecin and its conversion to Irinotecan hydrochloride by total synthesis.

Abstract translation: 本文公开了一种用于生产7-乙基-10-羟基喜树碱及其通过全合成转化为盐酸伊立替康的高度安全且易于扩展的方法。

公开(公告)号：WO2008120221A1

公开(公告)日：2008-10-09

申请号：PCT/IN2007/000220

申请日：2007-06-01

Applicant: SMIPHACON RESEARCH PVT. LTD. ,  RAMARAO, Chandrashekar ,  ALLA, Venkata, Rama, Rao

Inventor： RAMARAO, Chandrashekar ,  ALLA, Venkata, Rama, Rao

IPC: A23C9/13

CPC classification number: A23C9/13 ,  A23L33/105 ,  A23V2002/00 ,  A23V2250/2132 ,  A23V2250/21168 ,  A23V2200/30

Abstract: Disclosed herein is yogurt based nutritional compositions comprising polyphenolic compounds possessing demonstrated health and/or nutritional value, wherein the polyphenolic compounds are selected from Resveratrol, Fisetin and Quercetin derived from natural, synthetic and semi-synthetic origin.

Abstract translation: 本文公开了基于酸奶的营养组合物，其包含具有证明的健康和/或营养价值的多酚化合物，其中所述多酚化合物选自天然的，合成的和半合成来源的白藜芦醇，非瑟酮和槲皮素。

公开(公告)号：WO2007015259A3

公开(公告)日：2008-01-03

申请号：PCT/IN2005000326

申请日：2005-09-27

Applicant: AVRA LAB PVT LTD ,  RAO RAMAKRISHNA ,  ALLA VENKATA RAMA RAO

Inventor： ALLA VENKATA RAMA RAO

IPC: C07C209/36 ,  C07C201/08 ,  C07C205/45

CPC classification number: C07C221/00 ,  C07C29/40 ,  C07C45/305 ,  C07C201/08 ,  C07C201/12 ,  C07C205/45 ,  C07D491/22 ,  C07C225/22 ,  C07C33/483 ,  C07C33/46 ,  C07C49/807

Abstract: The present invention discloses a process for efficient production of 2-amino-5- hydroxypropiophenone corresponding to the AB ring part of camptothecin (CPT) skelton, which is a key intermediate useful for the total synthesis of camptothecin analogs including 7-Ethyl-10-hydroxy camptothecin and novel intermediates thereof.

Abstract translation: 本发明公开了一种有效生产对应于喜树碱（CPT）skelton的AB环部分的2-氨基-5-羟基苯丙酮的方法，其是用于全合成喜树碱类似物的关键中间体，包括7-乙基-10- 羟基喜树碱及其新型中间体。

公开(公告)号：WO2007015259A2

公开(公告)日：2007-02-08

申请号：PCT/IN2005/000326

申请日：2005-09-27

Applicant: AVRA LABORATORIES PVT. LTD. ,  RAO, Ramakrishna ,  ALLA, Venkata, Rama, Rao

Inventor： ALLA, Venkata, Rama, Rao

IPC: C07C209/36 ,  C07C201/08 ,  C07C205/45

CPC classification number: C07C221/00 ,  C07C29/40 ,  C07C45/305 ,  C07C201/08 ,  C07C201/12 ,  C07C205/45 ,  C07D491/22 ,  C07C225/22 ,  C07C33/483 ,  C07C33/46 ,  C07C49/807

Abstract: The present invention discloses a process for efficient production of 2-amino-5- hydroxypropiophenone corresponding to the AB ring part of camptothecin (CPT) skelton, which is a key intermediate useful for the total synthesis of camptothecin analogs including 7-Ethyl-10-hydroxy camptothecin and novel intermediates thereof.

Abstract translation: 本发明公开了一种有效生产对应于喜树碱（CPT）skelton的AB环部分的2-氨基-5-羟基苯丙酮的方法，其是用于全合成喜树碱类似物的关键中间体，包括7-乙基-10- 羟基喜树碱及其新型中间体。

公开(公告)号：US06541647B2

公开(公告)日：2003-04-01

申请号：US09969799

申请日：2001-10-02

Applicant: Mukund Shankar Chorghade ,  Mukund Keshao Gurjar ,  Palakodety Radha Krishna ,  Sista Venkata Sai Lalitha ,  Kashinath Sadalapure ,  Susanta Sekhar Adhikari ,  Andappan Murugaiah Subbaiah Murugaiah ,  Sunil Vyankatesh Mhaskar ,  Gangavaram Vasantha Madhava Sharma ,  Tangallapally Rajendra Prasad ,  Punna Sreenivas ,  Vavilala Goverdhan Reddy ,  Aminul Islam ,  Chittineni Hari Prasad ,  Alla Venkata Rama Rao

Inventor： Mukund Shankar Chorghade ,  Mukund Keshao Gurjar ,  Palakodety Radha Krishna ,  Sista Venkata Sai Lalitha ,  Kashinath Sadalapure ,  Susanta Sekhar Adhikari ,  Andappan Murugaiah Subbaiah Murugaiah ,  Sunil Vyankatesh Mhaskar ,  Gangavaram Vasantha Madhava Sharma ,  Tangallapally Rajendra Prasad ,  Punna Sreenivas ,  Vavilala Goverdhan Reddy ,  Aminul Islam ,  Chittineni Hari Prasad ,  Alla Venkata Rama Rao

IPC: C07D30733

CPC classification number: C07D307/14 ,  C07D307/12 ,  C07D307/32

Abstract: The invention includes inter alia new methods for preparation of the pharmaceutically active compound 2-(4-fluorophenoxymethyl)-5-(4-N-hydroxyureidyl-1 -butynyl)-tetrahydrofuran and precursors thereof.

Abstract translation: 本发明尤其包括制备药学活性化合物2-（4-氟苯氧基甲基）-5-（4-N-羟基脲基-1-丁炔基） - 四氢呋喃及其前体的新方法。

公开(公告)号：US06310221B1

公开(公告)日：2001-10-30

申请号：US09347087

申请日：1999-07-02

Applicant: Mukund Shankar Chorghade ,  Mukund Keshao Gurjar ,  Palakodety Radha Krishna ,  Sista Venkata Sai Lalitha ,  Kashinath Sadalapure ,  Susanta Sekhar Adhikari ,  Andappan Murugaiah Subbaiah Murugaiah ,  Sunil Vyankatesh Mhaskar ,  Gangavaram Vasantha Madhava Sharma ,  Tangallapally Rajendra Prasad ,  Punna Sreenivas ,  Vavilala Goverdhan Reddy ,  Aminul Islam ,  Chittineni Hari Prasad ,  Alla Venkata Rama Rao

Inventor： Mukund Shankar Chorghade ,  Mukund Keshao Gurjar ,  Palakodety Radha Krishna ,  Sista Venkata Sai Lalitha ,  Kashinath Sadalapure ,  Susanta Sekhar Adhikari ,  Andappan Murugaiah Subbaiah Murugaiah ,  Sunil Vyankatesh Mhaskar ,  Gangavaram Vasantha Madhava Sharma ,  Tangallapally Rajendra Prasad ,  Punna Sreenivas ,  Vavilala Goverdhan Reddy ,  Aminul Islam ,  Chittineni Hari Prasad ,  Alla Venkata Rama Rao

IPC: C07D30512

CPC classification number: C07D307/14 ,  C07D307/12 ,  C07D307/32

Abstract: The invention includes inter alia new methods for preparation of the pharmaceutically active compound 2-(4-fluorophenoxymethyl)-5-(4-N-hydroxyureidyl-1-butynyl)-tetrahydrofuran and precursors thereof.

Abstract translation: 本发明尤其包括制备药学活性化合物2-（4-氟苯氧基甲基）-5-（4-N-羟基脲基-1-丁炔基） - 四氢呋喃及其前体的新方法。

公开(公告)号：US5910465A

公开(公告)日：1999-06-08

申请号：US615855

申请日：1996-03-12

Applicant: Panja Kanta Rao ,  Kamaraju Seetha Rama Rao ,  Vattikonda Venkata Rao ,  Kalavaru Venkata Narayana ,  Akula Venugopal ,  Alla Venkata Rama Rao ,  Machiraju Subrahmanyam

Inventor： Panja Kanta Rao ,  Kamaraju Seetha Rama Rao ,  Vattikonda Venkata Rao ,  Kalavaru Venkata Narayana ,  Akula Venugopal ,  Alla Venkata Rama Rao ,  Machiraju Subrahmanyam

IPC: B01J27/198 ,  B01J27/182 ,  B01J27/192

CPC classification number: B01J23/002 ,  B01J27/198 ,  B01J2523/00

Abstract: This invention relates to a process for the preparation of highly active and selective ammoxidation catalyst of formula (VO).sub.2 P.sub.2 O.sub.7 ,TiO.sub.2 or (VO).sub.2 P.sub.2 O.sub.7, Al.sub.2 O.sub.3, which process comprises refluxing a vanadium source in the presence of alcohols; adding a source of phosphorous to form vanadyl pyrophosphate hydrate (VO).sub.2 H.sub.4 P.sub.2 O.sub.9 or (VO).sub.2 P.sub.2 O.sub.7.2H.sub.2 O ; Physical mixing of (VO).sub.2 H.sub.4 P.sub.2 O.sub.9 with oxides selected from titania or alumina, and heating the resultant mixture in the presence of air at a temperature in the range of 300-600.degree.C. for a period in the range of 1 to 10 hours; and the use of said ammoxidation catalyst in the preparation of heteroaromatic nitrites.

Abstract translation: 本发明涉及一种制备式（VO）2 P 2 O 7，TiO 2或（VO）2 P 2 O 7，Al 2 O 3的高活性和选择性氨氧化催化剂的方法，该方法包括在醇存在下回流钒源; 加入磷源形成焦磷酸氧钒水合物（VO）2H4P2O9或（VO）2P2O7.2H2O; （VO）2H 4 P 2 O 9与二氧化钛或氧化铝的氧化物的物理混合，在空气中，在300-600℃的温度范围内加热所得混合物1至10小时; 以及所述氨氧化催化剂在制备杂芳族亚硝酸盐中的用途。

公开(公告)号：US5952508A

公开(公告)日：1999-09-14

申请号：US37930

申请日：1998-03-10

Applicant: Panja Kanta Rao ,  Kamaraju Seetha Rama Rao ,  Vattikonda Venkata Rao ,  Kalevaru Venkata Narayana ,  Akula Venugopal ,  Alla Venkata Rama Rao ,  Machiraju Subrahmanyam

Inventor： Panja Kanta Rao ,  Kamaraju Seetha Rama Rao ,  Vattikonda Venkata Rao ,  Kalevaru Venkata Narayana ,  Akula Venugopal ,  Alla Venkata Rama Rao ,  Machiraju Subrahmanyam

IPC: B01J27/198 ,  C07D213/57 ,  B01J27/24

CPC classification number: B01J23/002 ,  B01J27/198 ,  B01J2523/00

Abstract: This invention relates to a process for the preparation of highly active and selective ammoxidation catalyst of formula (VO).sub.2 P.sub.2 O.sub.7, TiO.sub.2 or (VO).sub.2 P.sub.2 O.sub.7, Al.sub.2 O.sub.3, which process comprises refluxing a vanadium source in the presence of alcohols; adding a source of phosphorous to form vanadyl pyrophosphate hydrate (VO).sub.2 H.sub.4 P.sub.2 O.sub.9 or (VO).sub.2 P.sub.2 O.sub.7.2H.sub.2 O; Physical mixing of (VO).sub.2 H.sub.4 P.sub.2 O.sub.9 with oxides selected from titania or alumina, and heating the resultant mixture in the presence of air at a temperature in the range of 300-600.degree. C. for a period in the range of 1 to 10 hours; and the use of said ammoxidation catalyst in the preparation of heteroaromatic nitrites.

Abstract translation: 本发明涉及一种制备式（VO）2 P 2 O 7，TiO 2或（VO）2 P 2 O 7，Al 2 O 3的高活性和选择性氨氧化催化剂的方法，该方法包括在醇存在下回流钒源; 加入磷源形成焦磷酸氧钒水合物（VO）2H4P2O9或（VO）2P2O7.2H2O; （VO）2H 4 P 2 O 9与二氧化钛或氧化铝的氧化物的物理混合，在空气中，在300-600℃的温度范围内加热所得混合物1至10小时; 以及所述氨氧化催化剂在制备杂芳族亚硝酸盐中的用途。

公开(公告)号：US6130352A

公开(公告)日：2000-10-10

申请号：US826004

申请日：1997-03-27

Applicant: Yennu Sangiah Sadanandam ,  Meera Manjaya Shetty ,  Imtiaz Ahm Ansari ,  Jhillu Singh Yadav ,  Alla Venkata Rama Rao

Inventor： Yennu Sangiah Sadanandam ,  Meera Manjaya Shetty ,  Imtiaz Ahm Ansari ,  Jhillu Singh Yadav ,  Alla Venkata Rama Rao

IPC: C07C319/28 ,  C07C323/56 ,  C07B55/00 ,  C07C321/28

CPC classification number: C07C319/28 ,  C07B2200/07

Abstract: A process for the preparation of (+) (2S, 3S)-3-(2-aminophenylthio)-2-hydroxy-3-(4'-methoxyphenyl)-propionic acid which comprises treating the (.+-.) compound of (2RS, 3RS) 3-(2-aminophenylthio)-2-hydroxy-3-(4'-methoxyphenyl)-propionic acid (formula (II)) with the (+) compound of the 2-methylbenzylamine (formula (III)) and an alkali in the presence of a polar solvent, the amount of the compound of the formula (III) and the alkali being in half equivalent amount of compound of the formula (II) employed, separating the precipitate (+) amine salt form of (2-aminophenylthio)-2-hydroxy-3-(4'-methoxyphenyl)-propionic acid from the 1(-) salt form remaining in solution, by known methods treating the (+) amine salt from with an organic solvent and then decomposing the (+) amine salt form to produce (+)(2s, 3s)-3-(2-aminophenylthio)-2-hydroxy-3-(4'-methoxyphenyl)-propionic acid.

Abstract translation: （+）（2S，3S）-3-（2-氨基苯硫基）-2-羟基-3-（4'-甲氧基苯基） - 丙酸的制备方法，其包括（ 2RS，3RS）与2-甲基苄胺（式（III））的（+）化合物的3-（2-氨基苯硫基）-2-羟基-3-（4'-甲氧基苯基） - 丙酸（式（II） 和碱，在极性溶剂的存在下，式（III）化合物和碱的量为半量的式（II）化合物的用量，分离出沉淀（+）胺盐形式 （2-氨基苯硫基）-2-羟基-3-（4'-甲氧基苯基） - 丙酸从溶液中残留的1（ - ）盐形式，通过已知的方法用有机溶剂处理（+）胺盐，然后 分解（+）胺盐形成（+）（2s，3s）-3-（2-氨基苯硫基）-2-羟基-3-（4'-甲氧基苯基） - 丙酸。

公开(公告)号：US06566538B1

公开(公告)日：2003-05-20

申请号：US10185178

申请日：2002-06-27

Applicant: Mukund Shankar Chorghade ,  Mukund Keshao Gurjar ,  Palakodety Radha Krishna ,  Sista Venkata Sai Lalitha ,  Kashinath Sadalapure ,  Susanta Sekhar Adhikari ,  Andappan Murugaiah Subbaiah Murugaiah ,  Batchu Venkateswara Rao ,  Levadala Murali Krishna ,  Sunil Vyankatesh Mhaskar ,  Gangavaram Vasantha Madhava Sharma ,  Tangallapally Rajendra Prasad ,  Punna Sreenivas ,  Vavilala Goverdhan Reddy ,  Aminul Islam ,  Alla Venkata Rama Rao ,  Hymavathi Lanka ,  Bethi Sridhar Reddy ,  Chittineni Hari Prasad

Inventor： Mukund Shankar Chorghade ,  Mukund Keshao Gurjar ,  Palakodety Radha Krishna ,  Sista Venkata Sai Lalitha ,  Kashinath Sadalapure ,  Susanta Sekhar Adhikari ,  Andappan Murugaiah Subbaiah Murugaiah ,  Batchu Venkateswara Rao ,  Levadala Murali Krishna ,  Sunil Vyankatesh Mhaskar ,  Gangavaram Vasantha Madhava Sharma ,  Tangallapally Rajendra Prasad ,  Punna Sreenivas ,  Vavilala Goverdhan Reddy ,  Aminul Islam ,  Alla Venkata Rama Rao ,  Hymavathi Lanka ,  Bethi Sridhar Reddy ,  Chittineni Hari Prasad

IPC: C07D30512

CPC classification number: C07D307/33 ,  C07D307/12 ,  C07D309/06 ,  C07D313/04

Abstract: The invention provides new methods for preparation of cyclic oxygen compounds, including 2,5-disubstituted tetrahydrofurans, 2,6-disubstituted tetrahydropyrans, 2,7-disubstituted oxepanes and 2,8-oxocanes. The invention also provides new cyclic oxygen compounds and pharmaceutical compositions and therapeutic methods that comprise such compounds.