公开(公告)号：WO2006079007A2

公开(公告)日：2006-07-27

申请号：PCT/US2006/002229

申请日：2006-01-20

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  BALA SUBRAMANIAM, Anand ,  ABKARIAN, Manouk ,  FABRE, Adrien ,  DURAND, Marc ,  STONE, Howard, A.

Inventor： BALA SUBRAMANIAM, Anand ,  ABKARIAN, Manouk ,  FABRE, Adrien ,  DURAND, Marc ,  STONE, Howard, A.

IPC: B01D63/10

CPC classification number: B01D63/081 ,  B01D61/18 ,  B01D63/088 ,  B01D67/0034 ,  B01D71/70 ,  B01D2323/24 ,  B01D2325/028 ,  B01L3/5027

Abstract: The present invention includes a microfluidic filter and concentrator that can separate a filtrate from a fluid containing components, e.g. a suspension of particles, to be removed from the fluid at least to some extent. The filter may employ principals of tangential flow filtration, also known as cross-flow filtration. In one aspect, a microfluidic filter described herein includes at least a first, main channel and one or more secondary, filtering channels that connect to the main channel. Filtration occurs when a fluid portion of a sample that is flowed through the main channel enters one or more of the filtering channels and at least some of the components in the sample do not enter or do not flow through the secondary, filtering channels. The secondary channels may be dimensioned to inhibit flow of components through them, and/or a porous material such as a layer may be positioned to inhibit flow of components through the secondary channels.

Abstract translation: 本发明包括微流体过滤器和浓缩器，其可以从含有流体的组分例如流体中分离滤液。 至少在某种程度上要从流体中去除的颗粒悬浮液。 过滤器可以采用切向流过滤的原理，也称为错流过滤。 在一个方面，本文描述的微流体过滤器包括连接到主通道的至少第一主通道和一个或多个第二过滤通道。 当流过主通道的样品的流体部分进入一个或多个过滤通道并且样品中的至少一些组分不进入或不流过次级过滤通道时，发生过滤。 次级通道的尺寸可以被设定为抑制组分通过它们的流动，和/或可以设置诸如层的多孔材料以抑制组分通过次级通道的流动。

公开(公告)号：WO2006079007A3

公开(公告)日：2006-11-16

申请号：PCT/US2006002229

申请日：2006-01-20

Applicant: HARVARD COLLEGE ,  BALA SUBRAMANIAM ANAND ,  ABKARIAN MANOUK ,  FABRE ADRIEN ,  DURAND MARC ,  STONE HOWARD A

Inventor： BALA SUBRAMANIAM ANAND ,  ABKARIAN MANOUK ,  FABRE ADRIEN ,  DURAND MARC ,  STONE HOWARD A

IPC: B01D35/00 ,  B01D15/34 ,  B01D57/00 ,  B01D61/00 ,  B01D63/00

CPC classification number: B01D63/081 ,  B01D61/18 ,  B01D63/088 ,  B01D67/0034 ,  B01D71/70 ,  B01D2323/24 ,  B01D2325/028 ,  B01L3/5027

Abstract: The present invention includes a microfluidic filter and concentrator that can separate a filtrate from a fluid containing components, e.g. a suspension of particles, to be removed from the fluid at least to some extent. The filter may employ principals of tangential flow filtration, also known as cross-flow filtration. In one aspect, a microfluidic filter described herein includes at least a first, main channel and one or more secondary, filtering channels that connect to the main channel. Filtration occurs when a fluid portion of a sample that is flowed through the main channel enters one or more of the filtering channels and at least some of the components in the sample do not enter or do not flow through the secondary, filtering channels. The secondary channels may be dimensioned to inhibit flow of components through them, and/or a porous material such as a layer may be positioned to inhibit flow of components through the secondary channels.

Abstract translation: 本发明包括微流体过滤器和浓缩器，其可以将滤液与含有组分的流体分离，例如， 至少在一定程度上从流体中除去颗粒的悬浮液。 过滤器可以采用切向流过滤的原理，也称为交叉流过滤。 在一个方面，本文描述的微流控滤波器至少包括连接到主通道的第一主通道和一个或多个次级滤波通道。 当流过主通道的样品的流体部分进入一个或多个过滤通道并且样品中的至少一些组分不进入或不流过次级过滤通道时，发生过滤。 次级通道的尺寸可以限制通过它们的部件的流动，和/或诸如层的多孔材料可以被定位成阻止部件通过次级通道的流动。

公开(公告)号：WO2006078841A1

公开(公告)日：2006-07-27

申请号：PCT/US2006/001938

申请日：2006-01-20

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  BALA SUBRAMANIAM, Anand ,  ABKARIAN, Manouk ,  STONE, Howard, A.

Inventor： BALA SUBRAMANIAM, Anand ,  ABKARIAN, Manouk ,  STONE, Howard, A.

IPC: B01F13/00 ,  B01J13/00

CPC classification number: B01F13/0062 ,  B01F3/0807 ,  Y10T428/2984

Abstract: The present invention generally relates to systems and methods for forming fluidic droplets comprising particles such as colloidal particles, which may be distributed on the surfaces of the fluidic droplets in some cases, thereby encapsulating the fluidic droplets. The particles at least partially surrounding the fluidic droplet may be colloidal particles in some cases, i.e., forming a "colloidal capsule." In one set of embodiments, the particles may be positioned on the surface of a fluidic droplet such that the fluidic droplet is able to maintain a shape that, when left undisturbed, is not achievable by an undisturbed fluidic droplet free of discrete particles, for example, elongated or prolate ellipsoid fluidic droplets. Such fluidic droplets may also exhibit unusual properties, for example, plasticity, isolation from electromagnetic fields, certain electrical and/or magnetic properties, and/or mechanical resistance. In certain embodiments, multiple fluidic droplets may be prevented from fusing or coalescing into one droplet when coming into physical contact, due to the presence of particles on the fluidic droplets. However, the fluidic droplets may be induced into fusing or coalescing by initially deforming one or more of the fluidic droplets, e.g., mechanically.

Abstract translation: 本发明一般涉及用于形成流体液滴的系统和方法，其包括诸如胶体颗粒的颗粒，其在一些情况下可以分布在流体液滴的表面上，从而封装流体液滴。 至少部分围绕流体液滴的颗粒在某些情况下可能是胶体颗粒，即形成“胶体胶囊”。 在一组实施例中，颗粒可以定位在流体液滴的表面上，使得流体液滴能够保持一种形状，当不受干扰时，不能通过不受干扰的不含离散颗粒的流体液滴来实现，例如 ，细长或长椭圆形流体液滴。 这种流体液滴也可能表现出不寻常的特性，例如可塑性，与电磁场的隔离，某些电和/或磁特性和/或机械阻力。 在某些实施例中，由于流体液滴上存在颗粒，可以防止多个流体液滴在进入物理接触时熔融或聚结成一个液滴。 然而，流体液滴可以通过首先使一个或多个流体液滴变形（例如机械地）而被引入融合或聚结。