公开(公告)号：JP2011024579A

公开(公告)日：2011-02-10

申请号：JP2010172540

申请日：2010-07-30

Applicant: Cognetix Inc ,  Salk Inst ,  Univ Of Utah Research Foundation ,  コグネティックス・インコーポレイテッド ,  ソーク・インスティテュート ,  ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション

Inventor： CRAIG A GREY ,  GRIFFIN DAVID ,  OLIVERA BALDOMERO M ,  WATKINS MAREN ,  HILLYARD DAVID R ,  IMPERIAL JULITA ,  CRUZ LOURDES J ,  WAGSTAFF JOHN D ,  LAYER RICHARD T ,  JONES ROBERT M ,  MCCABE R TYLER

IPC: C12N15/09 ,  A61K38/00 ,  A61P1/00 ,  A61P1/04 ,  A61P1/12 ,  A61P7/02 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P9/14 ,  A61P21/00 ,  A61P25/04 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K7/08 ,  C07K9/00 ,  C07K14/435 ,  C07K14/575 ,  C12N15/12

CPC classification number: C07K7/08 ,  A61K38/00 ,  C07K9/001 ,  C07K14/575

Abstract: PROBLEM TO BE SOLVED: To provide contulakin-G, analogs thereof, and uses therefor.
SOLUTION: There are provided contulakin-G, a des-glycosylated contulakin-G (termed Thr
10 -contulakin-G) and derivatives thereof, a cDNA clone encoding a precursor of this mature peptide, and a precursor peptide. The use of this peptide is also provided as a therapeutic for anti-seizure, anti-inflammatory, anti-shock, anti-thrombus, hypotensive, analgesia, anti-psychotic, Parkinson's disease, gastrointestinal disorders, depressive states, cognitive dysfunction, anxiety, tardive dyskinesia, drug dependency, panic attack, mania, irritable bowel syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's chorea, vascular leakage, anti-arteriosclerosis, vascular and vasodilation disorders, as well as neurological, neuropharmacological, and neuropsychopharmacological disorders.
COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 待解决的问题：提供contulakin-G，其类似物及其用途。 提供了含有desulakin-G，一种去糖基化的抑制蛋白-G（称为Thr 10 -c-synulakin-G）及其衍生物，编码该成熟肽前体的cDNA克隆， 和前体肽。 还提供了该肽的用途，作为抗癫痫，抗炎，抗休克，抗血栓，降血压，镇痛，抗精神病，帕金森病，胃肠道疾病，抑郁状态，认知功能障碍，焦虑症， 迟发性运动障碍，药物依赖性，恐慌发作，躁狂症，肠易激综合征，腹泻，溃疡，胃肠道肿瘤，图雷特氏综合征，亨廷顿氏舞蹈病，血管渗漏，抗动脉硬化，血管和血管舒张障碍以及神经系统，神经药理学和神经精神药理学疾病 。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：US20040192886A1

公开(公告)日：2004-09-30

申请号：US10828478

申请日：2004-04-21

Applicant: The University of Utah Research Foundation ,  Cognetix, Inc.

Inventor： Baldomero M. Olivera ,  J. Michael McIntosh ,  James E. Garrett ,  Maren Watkins ,  Lourdes J. Cruz ,  Ki-Joon Shon ,  Richard B. Jacobsen ,  Robert M. Jones ,  G. Edward Cartier ,  Gregory S. Shen ,  John D. Wagstaff

IPC: A61K038/17 ,  C07K014/47

CPC classification number: C07K14/43504 ,  A61K38/00

Abstract: The present invention is to null-conopeptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated sodium channels. Thus, the null-conopeptides or derivatives are useful as neuromuscular blocking agents, local anesthetic agents, analgesic agents and neuroprotective agents. The null-conopeptides are also useful for treating neuromuscular disorders. The invention is further directed to nucleic acid sequences encoding the null-conopeptides and encoding propeptides, as well as the propeptides.

Abstract translation: 本发明涉及多肽，其衍生物或药学上可接受的盐。 本发明还涉及该肽，其衍生物和其药学上可接受的盐在治疗与电压门控钠通道相关的疾病中的用途。 因此，μ-肽或衍生物可用作神经肌肉阻滞剂，局部麻醉剂，止痛剂和神经保护剂。 多肽也可用于治疗神经肌肉疾病。 本发明还涉及编码多肽的核酸序列和编码前肽以及前肽。

公开(公告)号：US20040176278A1

公开(公告)日：2004-09-09

申请号：US10838226

申请日：2004-05-05

Applicant: University of Utah Research Foundation ,  Cognetix, Inc.

Inventor： Robert M. Jones ,  Baldomero M. Olivera ,  Maren Watkins ,  James E. Garrett

IPC: C07K014/435 ,  A61K038/17

CPC classification number: C07K14/43504

Abstract: The present invention is directed to null-superfamily conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, ligand gated channels and other receptors. The invention is further directed to nucleic acid sequences encoding the null-superfamily conotoxin peptides and encoding null-superfamily conotoxin propeptides, as well as the null-superfamily conotoxin propeptides.

Abstract translation: 本发明涉及β-超家族荚果毒素肽，其衍生物或药学上可接受的盐。 本发明进一步涉及该肽，其衍生物和其药学上可接受的盐在治疗与电压门控离子通道，配体门控通道和其它受体相关的病症中的用途。 本发明还涉及编码β-超家族荚果毒素肽和编码β-超家族荚果毒素前肽以及β-超家族荚果毒素前肽的核酸序列。

公开(公告)号：US20040132663A1

公开(公告)日：2004-07-08

申请号：US10765926

申请日：2004-01-29

Applicant: University of Utah Research Foundation ,  Cognetix, Inc.

Inventor： Baldomero M. Olivera ,  J. Michael McIntosh ,  Maren Watkins ,  James E. Garrett ,  Ki-Joon Shon ,  Richard B. Jacobsen ,  Robert M. Jones ,  G. Edward Cartier

IPC: A61K038/17 ,  C07K014/435 ,  C12Q001/68 ,  C07H021/04

CPC classification number: C07K14/43504 ,  A61K38/00

Abstract: The invention relates to null-conopeptides, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, as neuroprotective agents, as cardiovascular agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.

Abstract translation: 本发明涉及ω-肽，其衍生物或其药学上可接受的盐及其用途，包括治疗神经和精神疾病，如抗惊厥剂，神经保护剂，心血管药物或用于治疗疼痛。 本发明还涉及编码肽和编码前肽以及前肽的核酸序列。

公开(公告)号：US20130338338A1

公开(公告)日：2013-12-19

申请号：US13911596

申请日：2013-06-06

Applicant: COGNETIX, INC. ,  THE UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Maren WATKINS ,  Baldomero M. OLIVERA ,  David R. HILLYARD ,  J. Michael McIntosh ,  Robert M. JONES

IPC: C07K14/435 ,  C07K9/00 ,  C07K7/08

CPC classification number: C07K14/43504 ,  A61K38/00 ,  C07K7/08 ,  C07K9/00 ,  Y10S530/855 ,  Y10S530/857

Abstract: The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.

Abstract translation: 本发明涉及相对短的肽（本文中称为α-芋螺毒素），长度约10-30个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且其优选包括两个 二硫键。

公开(公告)号：US20040092447A1

公开(公告)日：2004-05-13

申请号：US10627685

申请日：2003-07-28

Applicant: Cognetix, Inc.

Inventor： Ann H. Cornell-Bell ,  Karen E. Pemberton ,  Davis L. Temple JR. ,  Richard T. Layer ,  R. Tyler McCabe ,  Robert M. Jones

IPC: A61K038/17 ,  A61K038/10

CPC classification number: A61K38/17 ,  C07K14/43504

Abstract: The invention relates to uses of kappa-conotoxin PVIIA (null-PVIIA), analogs and derivatives for activating ATP-sensitive Knull channels. The activation of ATP-sensitive Knull channels is useful for opening KATP channels which can be used to treat a wide range of disease and injury states, including cerebral and cardiac ischemia and asthma.

Abstract translation: 本发明涉及κ-芋螺毒素PVIIA（kappa-PVIIA），类似物和衍生物用于激活ATP敏感性K +通道的用途。 激活ATP敏感的K +通道可用于开放KATP通道，可用于治疗广泛的疾病和损伤状态，包括脑和心脏缺血和哮喘。

公开(公告)号：US20030096361A1

公开(公告)日：2003-05-22

申请号：US10213439

申请日：2002-08-07

Applicant: Cognetix, Inc.

Inventor： James E. Garrett ,  Pradip K. Bandypadhyay

IPC: C12Q001/68 ,  C07H021/04 ,  C12N009/10 ,  C12P021/02 ,  C12N005/06 ,  C07K014/435

CPC classification number: C12N9/93

Abstract: The present invention is relates to a null-carboxylase from Conus snails, a nucleic acid sequence encoding the Conus null-carboxylase and to a method for using the nucleic acid or protein sequences for preparing null-carboxylated proteins.

Abstract translation: 本发明涉及来自锥螺旋体的γ-羧化酶，编码柯氏γ-羧化酶的核酸序列以及使用该核酸或蛋白质序列制备γ-羧化蛋白质的方法。

公开(公告)号：US20040259794A1

公开(公告)日：2004-12-23

申请号：US10887203

申请日：2004-07-09

Applicant: Cognetix, Inc. ,  University of Utah Research Foundation

Inventor： Baldomero M. Olivera ,  J. Michael McIntosh ,  R. Tyler McCabe ,  James E. Garrett ,  Richard T. Layer ,  John D. Wagstaff ,  Robert M. Jones

IPC: A61K038/17

CPC classification number: C07K14/43504 ,  A61K38/17

Abstract: The present invention is directed to the new nullO-conopeptides, their coding sequences and their propeptides and to the use of nullO-conopeptides as a local anesthetic for treating pain. The nullO-conopeptides have long lasting anesthetic activity and are particularly useful for spinal anesthesia, either administered acutely for post-operative pain or via an intrathecal pump for severe chronic pain situations or for treatment of pain in epithelial tissue.

Abstract translation: 本发明涉及新的muO-肽，它们的编码序列及其前肽，以及使用muO-肽作为局部麻醉剂治疗疼痛。 muO-肽具有持久的麻醉活性，对于脊髓麻醉特别有用，无论是急性用于术后疼痛还是通过鞘内泵用于严重慢性疼痛情况或用于治疗上皮组织中的疼痛。

公开(公告)号：US20040204362A1

公开(公告)日：2004-10-14

申请号：US10839179

申请日：2004-05-06

Applicant: The University of Utah Research Foundation ,  Cognetix, Inc.

Inventor： Baldomero M. Olivera ,  Richard T. Layer ,  Maren Watkins ,  David R. Hillyard ,  J. Michael McIntosh ,  Robert Schoenfeld ,  Jacob Scott Nielsen ,  Robert M. Jones

IPC: A61K038/17 ,  C07K014/435 ,  C07H021/04

CPC classification number: C07K14/435 ,  A61K38/00 ,  C07K14/43504

Abstract: The invention relates to relatively short peptides (termed null-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The null-conotoxins, as described herein, are useful for as neuromuscular blocking agents, such as muscle relaxants.

Abstract translation: 本发明涉及相对短的肽（本文中称为α-芋螺毒素），长度约10-25个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且其优选包括两个 二硫键。 如本文所述，α-蛇毒毒素可用作神经肌肉阻滞剂，例如肌肉松弛剂。

公开(公告)号：US20040203132A1

公开(公告)日：2004-10-14

申请号：US10789450

申请日：2004-02-27

Applicant: Cognetix, Inc.

Inventor： Grzegorz Bulaj ,  Baldomero M. Olivera ,  Olga Buczek ,  James E. Garrett ,  Ian Goodsell

IPC: C12N009/90 ,  C07H021/04

CPC classification number: C07H21/04 ,  C12N9/90 ,  C12Y503/04001

Abstract: Protein disulfide isomerase is a major component of Conus venom ducts. The invention relates to a protein disulfide isomerase (PDI) from Conus snails, a nucleic acid sequence encoding the Conus protein disulfide isomerase, and to methods for folding disulfide-rich peptides using a protein disulfide isomerase. Oxidative folding of conotoxin precursors, catalyzed by a PDI, was more efficient and decreased the number and concentration of transiently accumulated folding species. The PDI-assisted oxidative folding of conotoxins was also influenced by the propeptide relative to the mature peptide.

Abstract translation: 蛋白二硫键异构酶是Conus毒液管的主要成分。 本发明涉及来自Conus蜗牛的蛋白质二硫键异构酶（PDI），编码康科斯蛋白二硫键异构酶的核酸序列，以及使用蛋白质二硫键异构酶折叠富含二硫键的肽的方法。 通过PDI催化的芋螺毒素前体的氧化折叠更有效，并且减少了瞬时积累的折叠物质的数量和浓度。 脯氨酸的PDI辅助氧化折叠也受到前肽相对于成熟肽的影响。