公开(公告)号：WO2011005969A2

公开(公告)日：2011-01-13

申请号：PCT/US2010041379

申请日：2010-07-08

Applicant: GEN HOSPITAL CORP ,  BRIGHAM & WOMENS HOSPITAL ,  RAINES DOUGLAS E ,  COTTEN JOSEPH F ,  FORMAN STUART A ,  MILLER KEITH W ,  HUSAIN SYED S ,  CUNY GREGORY D

Inventor： RAINES DOUGLAS E ,  FORMAN STUART A ,  MILLER KEITH W ,  HUSAIN SYED S ,  CUNY GREGORY D

IPC: C07D207/333 ,  A61K31/4164 ,  A61P5/38 ,  A61P25/00 ,  C07D233/64

CPC classification number: C07D207/34 ,  A61K31/40

Abstract: The invention is directed to compounds according to formula (I): where R1 is L1C(O)OT or L1C(O)OL2C(O)OT; R2 is a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, or R1; n is an integer from 0 to 5; each R3 is independently halogen or R2; R4 and R5 are independently H, halogen, CN or CF3; L1 and L2 are each independently a bond, a substituted or unsubstituted C1-C10 alkylene, C2-C10 alkenylene, or C2-C10 alkynylene; and T is H, a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, nitrophenol, or cyclopropyl. The invention is also directed to a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and to methods for providing anesthesia in mammals by administering such a pharmaceutical composition.

Abstract translation: 本发明涉及式（I）化合物：其中R1是L1C（O）OT或L1C（O）OL2C（O）OT; R2是取代或未取代的C1-C10烷基，C2-C10烯基或C2-C10炔基，或R1; n为0〜5的整数， 每个R 3独立地是卤素或R 2; R4和R5独立地为H，卤素，CN或CF3; L1和L2各自独立地为键，取代或未取代的C1-C10亚烷基，C2-C10亚烯基或C2-C10亚炔基; 和T是H，取代或未取代的C 1 -C 10烷基，C 2 -C 10烯基或C 2 -C 10炔基，硝基苯酚或环丙基。 本发明还涉及包含根据式（I）的化合物和药学上可接受的载体的药物组合物，以及通过施用这种药物组合物在哺乳动物中提供麻醉的方法。

公开(公告)号：WO2011005969A3

公开(公告)日：2011-01-13

申请号：PCT/US2010/041379

申请日：2010-07-08

Applicant: THE GENERAL HOSPITAL CORPORATION ,  THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  RAINES, Douglas E. ,  COTTEN, Joseph, F. ,  FORMAN, Stuart, A. ,  MILLER, Keith, W. ,  HUSAIN, Syed, S. ,  CUNY, Gregory, D.

Inventor： RAINES, Douglas E. ,  FORMAN, Stuart, A. ,  MILLER, Keith, W. ,  HUSAIN, Syed, S. ,  CUNY, Gregory, D.

IPC: C07D207/333 ,  C07D233/64 ,  A61K31/4164 ,  A61P5/38 ,  A61P25/00

Abstract: The invention is directed to compounds according to formula (I): where R 1 is L 1 C(O)OT or L 1 C(O)OL 2 C(O)OT; R 2 is a substituted or unsubstituted C 1 -C 10 alkyl, C 2 -C 10 alkenyl, or C 2 -C 10 alkynyl, or R 1 ; n is an integer from 0 to 5; each R 3 is independently halogen or R 2 ; R 4 and R 5 are independently H, halogen, CN or CF 3 ; L 1 and L 2 are each independently a bond, a substituted or unsubstituted C 1 -C 10 alkylene, C 2 -C 10 alkenylene, or C 2 -C 10 alkynylene; and T is H, a substituted or unsubstituted C 1 -C 10 alkyl, C 2 -C 10 alkenyl, or C 2 -C 10 alkynyl, nitrophenol, or cyclopropyl. The invention is also directed to a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and to methods for providing anesthesia in mammals by administering such a pharmaceutical composition.

公开(公告)号：WO2009146024A8

公开(公告)日：2010-04-08

申请号：PCT/US2009038872

申请日：2009-03-31

Applicant: GEN HOSPITAL CORP ,  RAINES DOUGLAS E ,  FORMAN STUART A ,  MILLER KEITH W ,  HUSAIN SYED SHAUKAT ,  COTTEN JOSEPH F

Inventor： RAINES DOUGLAS E ,  FORMAN STUART A ,  MILLER KEITH W ,  HUSAIN SYED SHAUKAT ,  COTTEN JOSEPH F

IPC: C07D233/58 ,  A61P23/00 ,  C07D233/56

CPC classification number: C07D233/90 ,  A61K31/4174 ,  A61K45/06

Abstract: The invention is directed to compounds according to formula (I): where R1 is L1C(O)OT or L1C(O)OL2C(O)OT; R2 is a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, or R1; n is an integer from 0 to 5; each R3 is independently halogen or R2; L1 and L2 are each independently a bond, a substituted or unsubstituted C1-C10 alkylene, C2-C10 alkenylene, or C2-C10 alkynylene; and T is H, a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, nitrophenol, or cyclopropyl. The invention is also directed to a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and to methods for providing anesthesia in mammals by administering such a pharmaceutical composition.

Abstract translation: 本发明涉及式（I）化合物：其中R1是L1C（O）OT或L1C（O）OL2C（O）OT; R2是取代或未取代的C1-C10烷基，C2-C10烯基或C2-C10炔基，或R1; n为0〜5的整数， 每个R 3独立地是卤素或R 2; L1和L2各自独立地为键，取代或未取代的C1-C10亚烷基，C2-C10亚烯基或C2-C10亚炔基; 和T是H，取代或未取代的C 1 -C 10烷基，C 2 -C 10烯基或C 2 -C 10炔基，硝基苯酚或环丙基。 本发明还涉及包含根据式（I）的化合物和药学上可接受的载体的药物组合物，以及通过施用这种药物组合物在哺乳动物中提供麻醉的方法。

公开(公告)号：WO2009146024A1

公开(公告)日：2009-12-03

申请号：PCT/US2009/038872

申请日：2009-03-31

Applicant: THE GENERAL HOSPITAL CORPORATION ,  RAINES, Douglas, E. ,  FORMAN, Stuart, A. ,  MILLER, Keith, W. ,  HUSAIN, Syed, Haukat ,  COTTEN, Joseph, F.

Inventor： RAINES, Douglas, E. ,  FORMAN, Stuart, A. ,  MILLER, Keith, W. ,  HUSAIN, Syed, Haukat ,  COTTEN, Joseph, F.

IPC: C07D233/58 ,  C07D233/56 ,  A61P23/00

CPC classification number: C07D233/90 ,  A61K31/4174 ,  A61K45/06

Abstract: The invention is directed to compounds according to formula (I): where R 1 is L 1 C(O)OT or L 1 C(O)OL 2 C(O)OT; R 2 is a substituted or unsubstituted C 1 -C 10 alkyl, C 2 -C 10 alkenyl, or C 2 -C 10 alkynyl, or R 1 ; n is an integer from 0 to 5; each R 3 is independently halogen or R 2 ; L 1 and L 2 are each independently a bond, a substituted or unsubstituted C 1 -C 10 alkylene, C 2 -C 10 alkenylene, or C 2 -C 10 alkynylene; and T is H, a substituted or unsubstituted C 1 -C 10 alkyl, C 2 -C 10 alkenyl, or C 2 -C 10 alkynyl, nitrophenol, or cyclopropyl. The invention is also directed to a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and to methods for providing anesthesia in mammals by administering such a pharmaceutical composition.

Abstract translation: 本发明涉及式（I）化合物：其中R1是L1C（O）OT或L1C（O）OL2C（O）OT; R2是取代或未取代的C1-C10烷基，C2-C10烯基或C2-C10炔基，或R1; n为0〜5的整数， 每个R 3独立地是卤素或R 2; L1和L2各自独立地为键，取代或未取代的C1-C10亚烷基，C2-C10亚烯基或C2-C10亚炔基; 和T是H，取代或未取代的C 1 -C 10烷基，C 2 -C 10烯基或C 2 -C 10炔基，硝基苯酚或环丙基。 本发明还涉及包含根据式（I）的化合物和药学上可接受的载体的药物组合物，以及通过施用这种药物组合物在哺乳动物中提供麻醉的方法。