公开(公告)号：WO2009149053A2

公开(公告)日：2009-12-10

申请号：PCT/US2009/045920

申请日：2009-06-02

Applicant: DR. REDDY'S LABORATORIES LTD. ,  DR. REDDY'S LABORATORIES, INC. ,  KOLLA, Naveen, Kumar ,  GANGULA, Srinivas ,  NAREDLA, Anitha ,  BADDAM, Sudhakar, Reddy ,  PATIL, Sumeet, Vishwasrao ,  SIGALA, Ashok ,  CHITTAPATHINA, Raghunath Babu, Venkata ,  MEDISETTI, Rama Krishna, Venkata ,  MANUDHANE, Kushal, Surajmal ,  NARRA, Santosh, Reddy ,  KOTAGIRI, Vijaya, Kumar

Inventor： KOLLA, Naveen, Kumar ,  GANGULA, Srinivas ,  NAREDLA, Anitha ,  BADDAM, Sudhakar, Reddy ,  PATIL, Sumeet, Vishwasrao ,  SIGALA, Ashok ,  CHITTAPATHINA, Raghunath Babu, Venkata ,  MEDISETTI, Rama Krishna, Venkata ,  MANUDHANE, Kushal, Surajmal ,  NARRA, Santosh, Reddy ,  KOTAGIRI, Vijaya, Kumar

IPC: C07C201/02 ,  C07C203/04 ,  A61K31/21

CPC classification number: C07C201/02 ,  C07B2200/13 ,  C07C69/734 ,  C07C203/04

Abstract: Processes for the preparation of naproxcinod and its purification, solid dispersions of naproxcinod with a pharmaceutically acceptable carrier, and processes for making dispersions. Also provided is crystalline 2-(S)-(4-chlorobutyl)-2-(6-methoxy-2-naphthyl)-propanoate and methods for its preparation.

Abstract translation: 用于制备萘普生和其纯化的方法，萘普生与药学上可接受的载体的固体分散体，以及制备分散体的方法。 还提供了2-（S） - （4-氯丁基）-2-（6-甲氧基-2-萘基） - 丙酸酯的结晶及其制备方法。

公开(公告)号：WO2009149053A3

公开(公告)日：2010-05-14

申请号：PCT/US2009045920

申请日：2009-06-02

Applicant: REDDYS LAB LTD DR ,  REDDYS LAB INC DR ,  KOLLA NAVEEN KUMAR ,  GANGULA SRINIVAS ,  NAREDLA ANITHA ,  BADDAM SUDHAKAR REDDY ,  PATIL SUMEET VISHWASRAO ,  SIGALA ASHOK ,  CHITTAPATHINA RAGHUNATH BABU VENKATA ,  MEDISETTI RAMA KRISHNA VENKATA ,  MANUDHANE KUSHAL SURAJMAL ,  NARRA SANTOSH REDDY ,  KOTAGIRI VIJAYA KUMAR

Inventor： KOLLA NAVEEN KUMAR ,  GANGULA SRINIVAS ,  NAREDLA ANITHA ,  BADDAM SUDHAKAR REDDY ,  PATIL SUMEET VISHWASRAO ,  SIGALA ASHOK ,  CHITTAPATHINA RAGHUNATH BABU VENKATA ,  MEDISETTI RAMA KRISHNA VENKATA ,  MANUDHANE KUSHAL SURAJMAL ,  NARRA SANTOSH REDDY ,  KOTAGIRI VIJAYA KUMAR

IPC: C07C201/02 ,  A61K31/21 ,  C07C203/04

CPC classification number: C07C201/02 ,  C07B2200/13 ,  C07C69/734 ,  C07C203/04

Abstract: Processes for the preparation of naproxcinod and its purification, solid dispersions of naproxcinod with a pharmaceutically acceptable carrier, and processes for making dispersions. Also provided is crystalline 2-(S)-(4-chlorobutyl)-2-(6-methoxy-2-naphthyl)-propanoate and methods for its preparation.

Abstract translation: 用于制备萘普生和其纯化的方法，萘普生与药学上可接受的载体的固体分散体，以及制备分散体的方法。 还提供了2-（S） - （4-氯丁基）-2-（6-甲氧基-2-萘基） - 丙酸酯的结晶及其制备方法。

公开(公告)号：WO2009117489A1

公开(公告)日：2009-09-24

申请号：PCT/US2009/037516

申请日：2009-03-18

Applicant: DR. REDDY'S LABORATORIES LTD. ,  DR. REDDY'S LABORATORIES, INC. ,  KOLLA, Naveen, Kumar ,  MANNE, Nagaraju ,  GANGULA, Srinivas ,  NEELAM, Udaykumar ,  NAREDLA, Anitha ,  BADDAM, Sudhakar, Reddy ,  PATIL, Sumeet, Vishwasrao ,  TUMMALA, Arjunkumar ,  PEDDIREDDY, Subbareddy ,  SHINDE, Sachin, Gulabrao ,  SIGALA, Ashok ,  MUDUNURU, Satish Varma ,  TUMMIDI, Madhu, Kiran

Inventor： KOLLA, Naveen, Kumar ,  MANNE, Nagaraju ,  GANGULA, Srinivas ,  NEELAM, Udaykumar ,  NAREDLA, Anitha ,  BADDAM, Sudhakar, Reddy ,  PATIL, Sumeet, Vishwasrao ,  TUMMALA, Arjunkumar ,  PEDDIREDDY, Subbareddy ,  SHINDE, Sachin, Gulabrao ,  SIGALA, Ashok ,  MUDUNURU, Satish Varma ,  TUMMIDI, Madhu, Kiran

IPC: C07D403/12 ,  C07D235/28 ,  C07D235/24

CPC classification number: C07D401/12 ,  A61K9/1635 ,  A61K9/1652 ,  A61K47/6951 ,  B82Y5/00

Abstract: Processes for the preparation of dexlansoprazole, an amorphous form of dexlansoprazole, a solid dispersion of amorphous dexlansoprazole and a pharmaceutically acceptable carrier, and processes for their preparation. Also provided are crystalline compounds 2-[(R)-[(4-chloro-3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole and 2-[(R)-[(4-nitro-3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, and methods for their preparation.

Abstract translation: 右兰索拉唑，无效形式的右兰索拉唑，无定形右兰索拉唑的固体分散体和药学上可接受的载体的方法及其制备方法。 还提供了结晶化合物2 - [（R） - [（4-氯-3-甲基-2-吡啶基）甲基]亚磺酰基] -1H-苯并咪唑和2 - [（R） - [（4-硝基-3- 甲基-2-吡啶基）甲基]亚磺酰基] -1H-苯并咪唑及其制备方法。