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公开(公告)号：KR100906478B1
公开(公告)日：2009-07-08
申请号：KR1020080003212
申请日：2008-01-10
Applicant: 강원대학교산학협력단
Abstract: A method for preparing a homoallenyl alcohol derivative is provided to selectively synthesize the homoallenyl alcohol derivative at high yield by reacting a synthesized organic indium reagent and an aldehyde compound. A method for preparing a homoallenyl alcohol derivative represented by chemical formula 1 comprises the steps of: reacting indium and propargyl chloride substituted with an ester group represented by chemical formula 2 to prepare an organic indium reagent; and adding an aldehyde compound represented by chemical formula 4. In chemical formula 1, 2 and 3, X is a halogen atom; R1 is a C1-C6 alkyl group; and R2 is a hydrogen atom, C1-C6 alkyl group, C3-C8 cycloalkyl group, phenyl group or phenyl-C1-C6 alkylene group. The benzene ring of phenyl or phenyl-C1-C6 alkylene group can be substituted or unsubstituted with 1-4 substituents selected from halogen, hydroxyl, nitro, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 acyl and C1-C6 alkoxycarbonyl.
Abstract translation: 提供一种制备均聚烯醇衍生物的方法，通过使合成的有机铟试剂和醛化合物反应，以高产率选择性地合成均聚烯醇衍生物。 制备由化学式1表示的均烯醇衍生物的方法包括以下步骤：使由化学式2表示的酯基取代的铟和炔丙基反应制备有机铟试剂; 并加入由化学式4表示的醛化合物。在化学式1,2和3中，X是卤原子; R1是C1-C6烷基; 并且R 2是氢原子，C 1 -C 6烷基，C 3 -C 8环烷基，苯基或苯基-C 1 -C 6亚烷基。 苯基或苯基-C 1 -C 6亚烷基的苯环可以被1-4个选自卤素，羟基，硝基，C 1 -C 6烷基，C 1 -C 6烷氧基，C 1 -C 6酰基和C 1 -C 6烷氧基羰基的取代基取代或未取代 。
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公开(公告)号：KR1020090088173A
公开(公告)日：2009-08-19
申请号：KR1020080013564
申请日：2008-02-14
Applicant: 강원대학교산학협력단
IPC: C07D307/30
Abstract: A dihydrofuran derivative is provided to improve yield of the dihydrofuran derivative through intramolecular cyclization of alenyl alcohol compound and use as a precursor in synthesis of medicine or perfume. A dihydrofuran derivative is denoted by the chemical formula 1. In the chemical formula 1, R is independently (C1-C7) alkyl group, A is hydrogen, (C1-C7)alkyl, (C3-C8)cycloalkyl, (C6-C20)aryl or (C6-C20)aryl(C1-C7)alkyl. The dihydrofuran derivative is a compound of the chemical formula 2 or 3. The dihydrofuran derivative of the chemical formula 1 is produced through intramolecular cyclization of homoalenyl alcohol compound.
Abstract translation: 提供二氢呋喃衍生物以通过烯丙醇化合物的分子内环化提高二氢呋喃衍生物的产率，并用作药物或香料的合成中的前体。 二氢呋喃衍生物由化学式1表示。在化学式1中，R独立地为（C 1 -C 7）烷基，A为氢，（C 1 -C 7）烷基，（C 3 -C 8）环烷基，（C 6 -C 20 ）芳基或（C 6 -C 20）芳基（C 1 -C 7）烷基。 二氢呋喃衍生物是化学式2或化学式3的化合物。化学式1的二氢呋喃衍生物通过分子内环化均聚烯醇化合物而产生。
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公开(公告)号：KR100941736B1
公开(公告)日：2010-02-11
申请号：KR1020080013564
申请日：2008-02-14
Applicant: 강원대학교산학협력단
IPC: C07D307/30
Abstract: 본 발명은 다이하이드로퓨란(dihydrofuran) 유도체 및 이의 제조방법에 관한 것이다. 보다 상세하게는, 금(Au) 촉매를 이용하여 알렌일 알코올 화합물의 분자내 고리화 반응을 통해 선택적으로 다이하이드로퓨란(dihydrofuran) 유도체를 제조하는 방법에 관한 것이다.
PPh3AuCl, AgOTf, 알렌일 알코올, 분자내 고리화반응, 다이하이드로퓨란(dihydrofuran)
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