公开(公告)号：KR101387353B1

公开(公告)日：2014-04-22

申请号：KR1020120002478

申请日：2012-01-09

Applicant: 강원대학교산학협력단

Inventor： 김현표 ,  고현정 ,  권용수 ,  서상욱

IPC: A61K36/25 ,  A61P31/12 ,  A61P31/16

Abstract: 본 발명은 아이비엽 추출물 및 이로부터 분리된 화합물을 유효성분으로 함유하는 조성물에 관한 것으로, 상세하게는 아이비엽 추출물 및 이로부터 분리된 화합물은 인플루엔자 바이러스 감염에 대한 치료 효과를 실험한 결과, 유의적인 치료효과를 나타냈고, 특히 기존 항인플루엔자제와의 병용투여시 강력한 인플루엔자 감염 치료효과을 나타냄을 확인함으로써, 상기 조성물을 인플루엔자 바이러스에 의한 감염증의 예방 및 치료용 약학조성물 또는 건강기능식품으로 유용하다.

公开(公告)号：KR1020130081478A

公开(公告)日：2013-07-17

申请号：KR1020120002478

申请日：2012-01-09

Applicant: 강원대학교산학협력단

Inventor： 김현표 ,  고현정 ,  권용수 ,  서상욱

IPC: A61K36/25 ,  A61P31/12 ,  A61P31/16

Abstract: PURPOSE: A hedera helix leaf extract or a compound separated from the same are provided to utilize as a medicinal composition for prevention and treatment of an infectious diseas by an influenza virus or a health functional food by checking a high survival rate when taken together with an antivirus agent. CONSTITUTION: A medicinal composition for prevention and treatment of an infectious disease caused by an influenza virus contains a Hedera helix leaf extract or hederacoside C separated from the same as an active ingredient. The Hedera helix leaft extract is a crude extract, a polar solvent soluble extract, and a non-polar solvent soluble extract. The medicinal moposition for prevention and treatment of an infectious disease contains the combination of the Hedera helix leaf extract or hederacoside C and an anti-influenza agent. The anti-influenza agent is selected from Oseltamivir (Tamiflu), Zanamivir (Relenza), Peramivir, Amantadine (Symmetrel), Rimantadine, Rivaririn, or Taribavirin. [Reference numerals] (AA) Survival rate; (BB) Medicine injection; (CC) Time (day) after infection; (DD) Extract of Ivy leaf

Abstract translation: 目的：提供野草螺旋叶提取物或与其分离的化合物，以利用流感病毒或健康功能性食物的预防和治疗感染性疾病的药物组合物，通过与 防毒剂。 构成：用于预防和治疗由流感病毒引起的感染性疾病的药物组合物含有与活性成分相同的间叶螺旋叶提取物或鲱鱼苷C。 Hedera螺旋提取物是粗提取物，极性溶剂可溶性提取物和非极性溶剂可溶性提取物。 用于预防和治疗感染性疾病的药物组合包含常春藤螺旋叶提取物或鲱鱼苷C与抗流感药剂的组合。 抗流感剂选自奥司他韦（Tamiflu），扎那米韦（Relenza），帕拉米韦，安他胺（Symmetrel），Rimantadine，Rivaririn或Taribavirin。 （附图标记）（AA）存活率; （BB）药物注射; （CC）感染后的时间（天） （DD）常春藤叶提取物

公开(公告)号：KR101369100B1

公开(公告)日：2014-03-03

申请号：KR1020120002479

申请日：2012-01-09

Applicant: 강원대학교산학협력단

Inventor： 김현표 ,  고현정 ,  권용수 ,  서상욱

IPC: A61K36/25 ,  A61K36/718 ,  A61P31/16 ,  A61P31/12

Abstract: 본 발명은 아이비엽 및 황련으로 구성된 복합생약 추출물을 유효성분으로 함유하는 조성물에 관한 것으로, 상세하게는 아이비엽 및 황련으로 구성된 복합생약 추출물은 인플루엔자 바이러스에 대한 억제활성을 실험한 결과, 강력한 억제활성을 나타냈고, 특히 기존 항바이러스제와의 병용투여시 높은 바이러스 억제 활성을 나타냄을 확인함으로써, 상기 조성물을 인플루엔자 바이러스에 의한 감염증의 예방 및 치료용 약학조성물 또는 건강기능식품으로 유용하다.

公开(公告)号：KR1020130081479A

公开(公告)日：2013-07-17

申请号：KR1020120002479

申请日：2012-01-09

Applicant: 강원대학교산학협력단

Inventor： 김현표 ,  고현정 ,  권용수 ,  서상욱

IPC: A61K36/25 ,  A61K36/718 ,  A61P31/16 ,  A61P31/12

Abstract: PURPOSE: A complex herbal medication extract composed of a Hedera helix leaf and a barberry root is provied to utilize as a medicinal composition for prevention and treatmentof an infectious disease caused by an influenza virus by checking survival rate when injected together with an anti-virus agent. CONSTITUTION: A medicinal composition for prevention and treatment of an infectious disease caused by an influenza virus contains a complex herbal extract with a complex herb medication composed of a Hedera helix leaf and a barberry root as an active component. a complex medicinal extract is a compound in which a dried weight ratio (w/w) of the Hedera helix leaf extract and the barberry root in 1-10:1 are mixed in a mixing ratio. The Hedera helix extract is a crude extract, a polar solvent extract, or a non-polar solvent soluble extract. The barberry extract is water, a low quality alcolhol with carbon number ranged from 1-4 such as methanol, butanol, an extract which is useful in a selected solvent from a mixed solvent or a bubbled butanolo extract. The medicinal composition for prevention and treatment of an infectious disease caused by an influenza virus contains the combination of the complex herbal medication extract composed of the Hedera helix leaf and the barberry root and an anti virus agent. [Reference numerals] (AA) Survival rate (%); (BB) Time (day) after infection; (CC) Ivy leaf; (DD) Ivy leaf + coptis

Abstract translation: 目的：通过检查与抗病毒剂一起注射的存活率，证明了由恒河螺旋叶和番茄根组成的复方草药药物提取物作为预防和治疗流感病毒感染性疾病的药物组合物 。 构成：用于预防和治疗由流感病毒引起的感染性疾病的药物组合物含有复方草本提取物，其中含有由常春藤螺旋叶和芭蕉根作为活性成分组成的复杂药草药物。 复合药用提取物是其中以1-10:1的比例混合上述恒河螺旋叶提取物和百日葵根的干燥重量比（w / w）的化合物。 常春藤螺旋提取物是粗提物，极性溶剂提取物或非极性溶剂可溶提取物。 木莓提取物是水，碳数低于1-4的低质量醇盐，例如甲醇，丁醇，可用于从混合溶剂或鼓泡丁酸提取物中选择的溶剂中的提取物。 用于预防和治疗由流感病毒引起的传染病的药物组合物包含由常春藤螺旋叶和越橘根组成的复方草药提取物和抗病毒剂的组合。 （AA）存活率（％） （BB）感染后的时间（天） （CC）常春藤叶; （DD）常春藤叶+黄连