公开(公告)号：KR1020110068414A

公开(公告)日：2011-06-22

申请号：KR1020090125359

申请日：2009-12-16

Applicant: 대구가톨릭대학교산학협력단

Inventor： 나영화 ,  김영수 ,  이응석

IPC: C07C205/36 ,  A61K8/40 ,  A61Q19/02

Abstract: PURPOSE: Hydroxyphenylether analogues are provided to ensure excellent DPPH free radical removal activity, monophenolase inhibitory activity of tyrosinase and α-MSH-induced melanin formation inhibition activity. CONSTITUTION: Hydroxyphenylether analogues are selected from the group consisting of 3,4,4',5-tetrabromo-2-hydroxy-2'-nitrodiphenylether, and 4'-bromo-2-hydroxy-2'-nitrodiphenylether, and 6-bromo-3-hydroxy-2'-nitrodiphenylether, 4-bromo-3-hydroxy-2'-nitrodiphenylether, and 4',6-dibromo-3-hydroxy-2'-nitrodiphenylether, and 4'-bromo-3-hydroxy-2'-nitrodiphenylether, and 5-hydroxy-3-methoxy-2'-nitrodiphenylether, 1-hydroxy-3,5-bis-(2-nitro- phenoxy)benzene, 4'-bromo-4-hydroxy-2'-nitrodiphenylether, 4-hydroxy-2'-nitrodiphenylether, and 4-hydroxy-3-methoxy-2'-nitrodiphenylether, 3,4-dihydroxy-2'-nitrodiphenylether, and 3,5-dihydroxy phenyl 3'-chlorobenzyl ether, 4-hydroxy phenyl 3'-dimethoxybenzyl ether, 4-hydroxy phenyl 4'-fluorobenzyl ether, 4-hydroxy phenyl 2'-chlorobenzyl ether, 4-hydroxy phenyl 3'-chlorobenzyl ether and 4-acetoxyphenyl 3',4'-dichlorobenzyl ether.

Abstract translation: 目的：提供羟基苯醚类似物以确保优异的DPPH自由基去除活性，酪氨酸酶的单酚酶抑制活性和α-MSH诱导的黑色素形成抑制活性。 构成：羟基苯醚类似物选自3,4,4'，5-四溴-2-羟基-2'-硝基二苯基醚和4'-溴-2-羟基-2'-硝基二苯基醚和6-溴 3-羟基-2'-硝基二苯基醚，4-溴-3-羟基-2'-硝基二苯基醚和4'，6-二溴-3-羟基-2'-硝基二苯基醚和4'-溴-3-羟基 - 2'-硝基二苯基醚和5-羟基-3-甲氧基-2'-硝基二苯基醚，1-羟基-3,5-双 - （2-硝基 - 苯氧基）苯，4'-溴-4-羟基-2'- 4-羟基-2'-硝基二苯基醚和4-羟基-3-甲氧基-2'-硝基二苯基醚，3,4-二羟基-2'-硝基二苯基醚和3,5-二羟基苯基3'-氯苄基醚4 - 羟基苯基3'-二甲氧基苄基醚，4-羟基苯基4'-氟苄基醚，4-羟基苯基2'-氯苄基醚，4-羟基苯基3'-氯苄基醚和4-乙酰氧基苯基3'，4'-二氯苄基醚 。