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公开(公告)号：KR1020100122225A
公开(公告)日：2010-11-22
申请号：KR1020090041161
申请日：2009-05-12
Applicant: 서울대학교산학협력단
CPC classification number: A61K47/36 , A61K9/1652 , A61K9/1682 , B82Y5/00 , C07K7/06
Abstract: PURPOSE: A chitosan nanoaprticle immobilized with M cell targeting peptide and a carrier for transferring oral vaccine containing the same are provided to use as a novel carrier for transferring oral vaccine. CONSTITUTION: A method for chitosan nanoparticle immobilized with M cell targeting peptide comprises: a step of conjugating M cell targeting peptide to water soluble chitosan to obtain M cell targeting peptide-water soluble chitosan; a step of adding tripolyphosphate(TPP) solution to the peptide-water soluble chitosan solution containing Tween 80; a step of performing sonication; and a step of centrifuging solution. The M cell targeting peptide has CKSYHPLSC sequence of sequence number 1.
Abstract translation: 目的：提供固定有M细胞靶向肽的壳聚糖纳米颗粒和用于转移含有它的口服疫苗的载体，用作转移口服疫苗的新型载体。 构成：固定有M细胞靶向肽的壳聚糖纳米颗粒的方法包括：将M细胞靶向肽与水溶性壳聚糖结合以获得靶向肽 - 水溶性壳聚糖的M细胞的步骤; 将三聚磷酸盐（TPP）溶液加入到含有吐温80的肽 - 水溶性壳聚糖溶液中的步骤; 执行超声处理的一个步骤; 和离心溶液的步骤。 M细胞靶向肽具有序列1的CKSYHPLSC序列。
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2.发明公开폐암 화상진단을 위한 Ｃｙ5.5로 표지된 폴레이트-ＰＥＧ-초상자성 산화철 나노입자 및 이를 이용한 폐암 화상진단용 조영제 无效标记为CY5.5的肺结核-PEG-超级氧化铁氧化物纳米颗粒用于肺癌成像和对照用于包含其的肺癌成像
公开(公告)号：KR1020110111779A
公开(公告)日：2011-10-12
申请号：KR1020100031028
申请日：2010-04-05
Applicant: 서울대학교산학협력단
CPC classification number: A61K49/0423 , A61K33/08 , G01N2800/7028
Abstract: 본 발명은 폴레이트-PEG를 제조하고, 이를 이용하여 초상자성 산화철 나노입자를 코팅한 후, 표면에 광학 화상진단을 위한 근적외선형광 염료를 표지시킨 Fol-PEG-SPIONs-Cy5.5 및 이를 이용한 폐암 화상진단용 조영제에 관한 것으로, 본 발명에 따른 Fol-PEG-SPIONs-Cy5.5는 낮은 세포독성을 나타내고, in vitro 및 in vivo 모두에서 암세포에 대한 표적화 운반 효율을 증진시키며, 종양 위치를 보다 명료하게 확인할 수 있는 효과가 있다.
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公开(公告)号：KR101132412B1
公开(公告)日：2012-04-03
申请号：KR1020090041161
申请日：2009-05-12
Applicant: 서울대학교산학협력단
Abstract: PURPOSE: A chitosan nanoaprticle immobilized with M cell targeting peptide and a carrier for transferring oral vaccine containing the same are provided to use as a novel carrier for transferring oral vaccine. CONSTITUTION: A method for chitosan nanoparticle immobilized with M cell targeting peptide comprises: a step of conjugating M cell targeting peptide to water soluble chitosan to obtain M cell targeting peptide-water soluble chitosan; a step of adding tripolyphosphate(TPP) solution to the peptide-water soluble chitosan solution containing Tween 80; a step of performing sonication; and a step of centrifuging solution. The M cell targeting peptide has CKSYHPLSC sequence of sequence number 1.
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