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公开(公告)号：KR1020080083438A
公开(公告)日：2008-09-18
申请号：KR1020070023991
申请日：2007-03-12
Applicant: 성균관대학교산학협력단
CPC classification number: A61K31/35
Abstract: A composition comprising a polyphenol material is provided to be useful as a controlling agent of SNARE involved intracellular reaction by controlling release of neurotransmitter, thereby being applied as composition for improving wrinkles or mitigating pains. A composition for modulating neurotransmitter release comprises at least one polyphenol selected from the group consisting of kaempferol, quercetin, myricetin, luteolin, delphinidin, cyanidin, butein, ellagic acid and a derivative thereof as an effective ingredient. A pharmaceutical composition for mitigating pain comprises a pharmaceutically acceptable carrier and at least one polyphenol selected from the group consisting of kaempferol, quercetin, myricetin, luteolin, delphinidin, cyanidin, butein, ellagic acid and a derivative thereof.
Abstract translation: 提供了包含多酚材料的组合物，可用作通过控制神经递质释放而涉及细胞内反应的SNARE的控制剂，从而作为用于改善皱纹或缓解疼痛的组合物。 用于调节神经递质释放的组合物包含至少一种选自山奈酚，槲皮素，杨梅素，木犀草素，花翠素，花青素，丁烯，鞣花酸及其衍生物作为有效成分的多酚。 用于减轻疼痛的药物组合物包含药学上可接受的载体和至少一种选自山奈酚，槲皮素，杨梅素，木犀草素，花翠素，花青素，丁烯，鞣花酸及其衍生物的多酚。
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公开(公告)号：KR1020090041066A
公开(公告)日：2009-04-28
申请号：KR1020070106584
申请日：2007-10-23
Applicant: 성균관대학교산학협력단
IPC: C07K7/00
Abstract: A synthetic peptide which is similar to a kernel composite of SNARE(Soluble ethylmaleimide-sensitive factor attachment protein) is provided to control a neutrotransmitter release by hindering the formation of SNARE composite and to ensure the control of the intercellular reaction, improvement of skin wrinkle and pain relieving effects. A peptide fragment controlling a neutrotransmitter release by suppressing the formation of SNARE composite is the whole(SEQ ID NO:2) of peptides configuring N-end part of the core domain of syntaxin 1a protein forming the SNARE composite or a part of peptides; the whole(SEQ ID NO:4) of peptides configuring N-end part of C-helix of SNAP-25 forming the SNARE composite or a part of peptides; and the whole(SEQ ID NO:8) of peptides configuring N-end part of core domain from VAMP-2 protein forming the SNARE composite or a part of peptides.
Abstract translation: 提供类似于SNARE（可溶性乙基马来酰亚胺敏感因子附着蛋白）的核复合物的合成肽，以通过阻碍SNARE复合物的形成来控制中性转运体释放，并确保控制细胞间反应，改善皮肤皱纹和 止痛效果。 通过抑制SNARE复合物的形成来控制中性转运体释放的肽片段是构成形成SNARE复合物或部分肽的syntaxin 1a蛋白的核心结构域的N末端部分的肽的整个（SEQ ID NO：2） 构成形成SNARE复合物或部分肽的SNAP-25的C-螺旋的N末端的肽的整个（SEQ ID NO：4） 和形成SNARE复合物的VAMP-2蛋白的核结构域的N末端部分的肽的全部（SEQ ID NO：8）或肽的一部分。
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公开(公告)号：KR100913917B1
公开(公告)日：2009-08-26
申请号：KR1020080083883
申请日：2008-08-27
Applicant: 성균관대학교산학협력단
Abstract: 본 발명은 천연물 추출물을 유효성분으로 포함하는 신경전달물질 배출 조절용 조성물에 관한 것이다. 본 발명의 조성물은 SNARE 복합체 형성의 저해제로서 신경전달물질 배출을 조절함으로써 SNARE가 관여하는 세포내 반응의 조절제로 유용하다. 본 발명의 SNARE 복합체 형성 저해제는 피부 통증 완화용 조성물로 활용될 수 있다.
천연물 추출물, SNARE, 신경전달물질, 막융합-
公开(公告)号：KR1020080082955A
公开(公告)日：2008-09-12
申请号：KR1020080083883
申请日：2008-08-27
Applicant: 성균관대학교산학협력단
Abstract: A composition is provided to be useful as an inhibitor of SNARE(soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex formation by controlling release of a neurotransmitter, thereby being applicable as a pain alleviating composition. A composition for mitigating pain comprises 0.001-50 wt.% of an extract of one natural material selected from the group consisting of leaves, flowers and stems of Carpinus tschonoskii; spikes of Platycarya strobilacea and Meliosma myriantha; aerial whole plants of Sedum kamtschaticum and Potentilla cryptotaeniae; stems of Euscaphis japonica and Juglans sinensis; roots of Boehmeria nivea; leaves of Schizophragma; flowers of Castanea crenata; and leaves and stems of Maackia amurensis, Elaeagnus umbellata, Rhus chinensis, Lindera erythrocarpa, Rubus crataegifolius, Cornus kousa, and Robinia pseudo-accacia, and a pharmaceutically acceptable carrier, diluent or excipient.
Abstract translation: 通过控制神经递质的释放，提供了可用作SNARE（可溶性N-乙基马来酰亚胺敏感因子附着蛋白受体）复合体形成抑制剂的组合物，因此可用作疼痛缓解组合物。 用于减轻疼痛的组合物包含0.001-50重量％的选自由Carpinus tschonoskii的叶，花和茎的一种天然材料的提取物; Platycarya strobilacea和Meliosma myriantha的尖峰; 天竺葵um;;;;;;;;;;;;;;;;;;;; E草和胡桃茎; Boehmeria nivea的根; Sch Cast藜花; 以及马鞭草，叶桉，中华ensis，林era，红，，ia ia和假and and的叶和茎以及药学上可接受的载体，稀释剂或赋形剂。
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Patent Agency Ranking
公开(公告)号：KR1020080056576A
公开(公告)日：2008-06-23
申请号：KR1020060129644
申请日：2006-12-18
Applicant: 성균관대학교산학협력단
CPC classification number: A61K36/52 , A61K36/41 , A61K36/48 , A61K2236/33 , A61K2236/51 , A61Q19/08
Abstract: A composition comprising an extract of natural materials is provided to be useful as a controlling agent of intracellular reaction with which SNARE(soluble N-ethylmaleimide-sensitive factor attachment protein receptor) is involved by controlling release of neurotransmitter and be applied as a composition for improving wrinkles and alleviating pains. A composition for inhibiting SNARE comprises an extract extracted from at least one natural materials selected from the group consisting of Carpinus tschonoskii, Platycarya strobilacea, Sedum kamtschaticum, Meliosma myriantha, Maackia amurensis, Euscaphis japonica, Boehmeria nivea, Potentilla cryptotaeniae, Schizophragma hydrangeoides, Castanea crenata, Elaeagnus umbellata, Rubus coreanus, Rhus chinensis, Lindera erythrocarpa, Rubus crataegifolius, Cornus kousa, Robinia pseudo-acacia and Juglans sinensis, a pharmaceutically acceptable carrier, a diluent or an excipient. A method for extracting the extract from the natural materials comprises the steps of: (a) crushing the natural materials; (b) extracting the crushed material with methanol, ethanol or water and freeze-drying the extract; and (c) dissolving a material obtained from the step(b) in water.
Abstract translation: 提供包含天然物质提取物的组合物，可用作通过控制神经递质的释放而涉及SNARE（可溶性N-乙基马来酰亚胺敏感因子附着蛋白受体）的细胞内反应的控制剂，并用作改善用组合物 皱纹和缓解疼痛。 用于抑制SNARE的组合物包含从至少一种天然材料提取的提取物，所述天然材料选自Carpinus tschonoskii，野菜，Sedum kamtschaticum，Meliosma myriantha，Maackia amurensis，Euscaphis japonica，Boehmeria nivea，Potentilla cryptotaeniae，Schizophragma cavrangeoides，Castanea crenata ，榆树（Elaeagnus umbellata），红钩虫属（Rubus coreanus），中华ensis ensis（Rhus chinensis），枸杞（Lindera erythrocarpa），红钩虫（Rubus crataegifolius），萸，属（Cornus kousa），刺槐拟拟相思和胡桃木胡椒（Juglans sinensis），药学上可接受的载体，稀释剂或赋形剂。 从天然材料中提取提取物的方法包括以下步骤：（a）粉碎天然材料; （b）用甲醇，乙醇或水萃取破碎的物料，冷冻干燥; 和（c）将从步骤（b）获得的材料溶于水中。
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公开(公告)号：KR100901078B1
公开(公告)日：2009-06-03
申请号：KR1020070106592
申请日：2007-10-23
Applicant: 성균관대학교산학협력단
Abstract: 본 발명은 호랑버들, 오미자, 황근, 부들, 싸리, 애기부들, 큰꿩의 비름, 진달래, 쪽, 마가목, 감나무, 동백나무, 생강나무, 굴피나무, 딱지꽃, 밤나무, 말오줌때, 서어나무, 료양화, Negesvari, Raj briksha, Dhayaro, 월계화 및 매괴화의 꽃 추출물에 관한 것이다. 본 발명에 따른 꽃 추출물은 SNARE 복합체의 형성을 저해하여 신경전달물질 배출을 조절하고, BoNT(Botulinum neurotoxin)보다 저렴하게 원료를 제공할 수 있으며, 천연 소재이므로 소비자에게 친숙한 접근이 가능하여 산업적으로 매우 유용하다.
SNARE (Soluble N-ethylmaleimide-sensitive factor attachment protein receptor) 복합체, 신경전달물질, 추출물, 보톡스(BoNT)Abstract translation: 本发明黄花柳，五味子，hwanggeun，零部件，萩，香蒲，keunkkwong，杜鹃花，侧面，山灰，柿子树，山茶花，生姜，木材，化香，黑星病花，栗子，马小便时，鹅耳枥树苋菜， Negesvari，Raj briksha，Dhayaro，Laurelia和Mastiflora。 根据本发明的花提取物是抑制SNARE复合控制神经递质放电的形成，并能廉价地提供的原料比的BoNT（肉毒杆菌神经毒素），天然材料，因为它是为消费者熟悉的访问工业上非常 这很有用。
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公开(公告)号：KR1020090041071A
公开(公告)日：2009-04-28
申请号：KR1020070106592
申请日：2007-10-23
Applicant: 성균관대학교산학협력단
Abstract: Flower extracts inhibiting the formation of SNARE(Soluble ethylmaleimide-sensitive factor attachment protein) composite is to be safe capered with conventional skin care using Botox and to improve the stability within the formulation of skin wrinkle remedies. A composition for suppressing the formation of SNARE composite comprises flower extracts. The flower extracts are obtained by extracting the flower of plant in water or C1-C4 alcohol. The composition has the improvement of skin wrinkle, the control of activities within cells and pain relieving effect.
Abstract translation: 抑制形成SNARE（可溶性乙基马来酰亚胺敏感因子附着蛋白）复合材料的花提取物可以通过使用肉毒杆菌的常规护肤来安全，并提高皮肤皱纹补救剂配方中的稳定性。 用于抑制SNARE复合物形成的组合物包括花提取物。 花提取物是通过提取植物在水中的花或C1-C4醇获得的。 该组合物具有改善皮肤皱纹，控制细胞内活性和缓解疼痛的作用。
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公开(公告)号：KR100883757B1
公开(公告)日：2009-02-12
申请号：KR1020070023991
申请日：2007-03-12
Applicant: 성균관대학교산학협력단
CPC classification number: A61K31/35
Abstract: 본 발명은 식물 폴리페놀 물질을 유효성분으로 포함하는 신경전달물질 배출 조절용 조성물에 관한 것이다. 본 발명의 조성물은 SNARE 복합체 형성의 저해제로서 신경전달물질 배출을 조절함으로써 SNARE가 관여하는 세포내 반응의 조절제로 유용하다. 본 발명의 SNARE 복합체 형성 저해제는 주름개선용, 통증완화용 조성물로 활용될 수 있다.
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公开(公告)号：KR100859950B1
公开(公告)日：2008-09-23
申请号：KR1020060129644
申请日：2006-12-18
Applicant: 성균관대학교산학협력단
Abstract: 본 발명은 천연물 추출물을 유효성분으로 포함하는 신경전달물질 배출 조절용 조성물에 관한 것이다. 본 발명의 조성물은 SNARE 복합체 형성의 저해제로서 신경전달물질 배출을 조절함으로써 SNARE가 관여하는 세포내 반응의 조절제로 유용하다. 본 발명의 SNARE 복합체 형성 저해제는 주름개선용, 통증완화용 조성물로 활용될 수 있다.
천연물 추출물, SNARE, 신경전달물질, 막융합
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