公开(公告)号：KR1020080108736A

公开(公告)日：2008-12-16

申请号：KR1020070056687

申请日：2007-06-11

Applicant: 재단법인서울대학교산학협력재단

Inventor： 박승범 ,  김관 ,  박형건 ,  이향연

IPC: D06M11/42 ,  D06M13/144 ,  B82Y40/00 ,  D06M11/83

CPC classification number: D06M11/42 ,  B82Y40/00 ,  D06M11/83 ,  D06M13/144 ,  D10B2401/13 ,  D10B2509/022 ,  D10B2509/024

Abstract: A manufacturing method of antibacterial fiber in which nanosilver particle is coated is provided to control arbitrarily a size and a thickness of nanosilver particle coated on the fiber by controlling a relative concentration of a reactant. A manufacturing method of antibacterial fiber in which nanosilver particle is coated comprises a step of coating the nanosilver particle on fiber containing an alcohol functional group using a mixture including silver ion and aliphatic group or an aromatic amine compound. A pKa of the aliphatic group or the aromatic amine compound is 5 or greater. A relative concentration of the aliphatic amine compound and the silver ion is 1:0.1 or 1:5. A total concentration of the aliphatic amine compound and the silver ion is 10^-6 - 1 mol/liter.

Abstract translation: 提供其中涂覆有纳米银颗粒的抗菌纤维的制造方法，通过控制反应物的相对浓度来任意地控制涂覆在纤维上的纳米银颗粒的尺寸和厚度。 包含纳米银颗粒的抗菌纤维的制造方法包括使用包含银离子和脂肪族基团或芳香族胺化合物的混合物将纳米银粒子涂布在含有醇官能团的纤维上的工序。 脂肪族基团或芳香族胺化合物的pKa为5以上。 脂族胺化合物和银离子的相对浓度为1:0.1或1:5。 脂族胺化合物和银离子的总浓度为10 -6 -6 mol / L。

公开(公告)号：KR1020080087301A

公开(公告)日：2008-10-01

申请号：KR1020070029334

申请日：2007-03-26

Applicant: 재단법인서울대학교산학협력재단

Inventor： 박승범 ,  조명행 ,  이향연 ,  박종민

IPC: C07H3/00

CPC classification number: C07H3/00

Abstract: A glucose derivative is provided to show excellent capability as a glucose absorption tracer compared to a conventional 2-NBDG and monitor the glucose absorption in a normal culture medium state, thereby being usefully used for molecular imaging, bio-analysis, and screening a drug for treating or preventing glucose metabolism related diseases. A glucose derivative labeled with a fluorescent dye is represented by a formula(1) or (2), wherein R1 is -(CH2)n-NH- or -(CH2)n-NH-(C2H4X)m-NH-(wherein n is an integer from 1 to 10, m is an integer from 1 to 100, and X may be same or different from one another when the m is at least 2 and X is CH2, O or a single bond); R2 is a fluorescent dye; and Y is O or S. A method for synthesizing the glucose derivative of the formula(1) or (2) is characterized in that the fluorescent dye is labeled through O-1-glycosylation. A method for molecular imaging is characterized in that the glucose derivative labeled with the fluorescent dye is used as a bio-probe. A method for high throughput screening of a drug for treating or preventing glucose metabolism related diseases is characterized in that the glucose derivative labeled with the fluorescent dye is used as a probe.

Abstract translation: 提供葡萄糖衍生物以与常规的2-NBDG相比作为葡萄糖吸收示踪剂具有优异的能力，并监测正常培养基状态下的葡萄糖吸收，从而有效地用于分子成像，生物分析和筛选药物 治疗或预防葡萄糖代谢相关疾病。 用荧光染料标记的葡萄糖衍生物由式（1）或（2）表示，其中R1是 - （CH2）n-NH-或 - （CH2）n-NH-（C2H4X）m-NH-（其中 n为1〜10的整数，m为1〜100的整数，当m为2以上且X为CH 2，O或单键时，X可以相同或不同。 R2是荧光染料; 并且Y是O或S.用于合成式（1）或（2）的葡萄糖衍生物的方法的特征在于荧光染料通过O-1-糖基化被标记。 用于分子成像的方法的特征在于，用荧光染料标记的葡萄糖衍生物用作生物探针。 用于治疗或预防葡萄糖代谢相关疾病的药物的高通量筛选的方法的特征在于，用荧光染料标记的葡萄糖衍生物用作探针。

公开(公告)号：KR100876111B1

公开(公告)日：2008-12-26

申请号：KR1020070056687

申请日：2007-06-11

Applicant: 재단법인서울대학교산학협력재단

Inventor： 박승범 ,  김관 ,  박형건 ,  이향연

IPC: D06M11/42 ,  D06M13/144 ,  B82Y40/00 ,  D06M11/83

Abstract: A manufacturing method of antibacterial fiber in which nanosilver particle is coated is provided to control arbitrarily a size and a thickness of nanosilver particle coated on the fiber by controlling a relative concentration of a reactant. A manufacturing method of antibacterial fiber in which nanosilver particle is coated comprises a step of coating the nanosilver particle on fiber containing an alcohol functional group using a mixture including silver ion and aliphatic group or an aromatic amine compound. A pKa of the aliphatic group or the aromatic amine compound is 5 or greater. A relative concentration of the aliphatic amine compound and the silver ion is 1:0.1 or 1:5. A total concentration of the aliphatic amine compound and the silver ion is 10^-6 - 1 mol/liter.

Abstract translation: 提供其中涂覆有纳米银粒子的抗菌纤维的制造方法，以通过控制反应物的相对浓度来任意地控制涂覆在纤维上的纳米银粒子的尺寸和厚度。 其中涂覆有纳米银颗粒的抗菌纤维的制造方法包括使用包含银离子和脂族基团的混合物或芳族胺化合物将纳米银颗粒涂覆在含有醇官能团的纤维上的步骤。 脂肪族基团或芳香族胺化合物的pKa为5以上。 脂族胺化合物和银离子的相对浓度为1:0.1或1:5。 脂族胺化合物和银离子的总浓度为10 ^ -6-1mol / l。

公开(公告)号：KR100874761B1

公开(公告)日：2008-12-19

申请号：KR1020070029334

申请日：2007-03-26

Applicant: 재단법인서울대학교산학협력재단

Inventor： 박승범 ,  조명행 ,  이향연 ,  박종민

IPC: C07H3/00

CPC classification number: C07H3/00

Abstract: The present invention relates to a fluorescent dye-labeled glucose analog, and a synthesis method and usage of the same, and more particularly, to novel glucose α and &bgr; anomers in which a fluorescent dye is labeled by O-1-glycosylation, an asymmetric synthesis method of the anomers, a molecular bioimaging method of the anomers, and a screening method of curing or preventing drugs for diseases related to glucose metabolism.

Abstract translation: 荧光染料标记的葡萄糖类似物及其合成方法和用途技术领域本发明涉及荧光染料标记的葡萄糖类似物及其合成方法和用途，并且更具体地涉及新型葡萄糖＆amp; 和＆amp; bgr; 其中通过O-1-糖基化标记荧光染料的端基异构体，端基异构体的不对称合成方法，端基异构体的分子生物成像方法，以及用于治疗或预防与葡萄糖代谢有关的疾病的药物的筛选方法。