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公开(公告)号：KR101080851B1
公开(公告)日：2011-11-08
申请号：KR1020090038430
申请日：2009-04-30
Applicant: 전남대학교산학협력단
Inventor： 이귀숙
Abstract: 본발명의스테로이드합성저해용 ARR19는동물의호르몬이과다생성되어나타나는질병을예방및 치료하기위하여의약분야등에유용하게사용될수 있으며, 이를통하여체내의항상성을유지시키는호르몬을효과적으로조절할수 있는부작용이없는조절제로서의역할을한다.
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Patent Agency Ranking
公开(公告)号：KR1020070105757A
公开(公告)日：2007-10-31
申请号：KR1020060038319
申请日：2006-04-27
Applicant: 전남대학교산학협력단
CPC classification number: A61K48/00 , C12N7/00 , C12N15/66 , Y10S424/801
Abstract: A prostate cancer treating agent is provided to induce overexpression of HNF-3alpha(hepatocyte nuclear factor 3 alpha) which controls transcription in hepatocyte, nasal epithelial cell and epithelial cells of prostate and colon, and is associated with apoptosis of prostate cancer cells by retinoid. A prostate cancer treating agent comprises an expression vector containing a gene encoding HNF-3alpha having the nucleotide sequence of SEQ ID NO:1 and overexpressing the HNF-3alpha in a prostate cancer cell, wherein the expression vector is a virus vector such as adenovirus vector, wherein the overexpression of the HNF-3alpha induces release of mitochondria cytochrome C into cytoplasm in the prostate cancer cell which is a characteristic of apoptosis.
Abstract translation: 提供前列腺癌治疗剂以诱导控制前列腺和结肠肝细胞，鼻上皮细胞和上皮细胞转录的HNF-3α（肝细胞核因子3α）的过度表达，并与类视黄醇相关的前列腺癌细胞的凋亡相关。 前列腺癌治疗剂包含含有编码具有SEQ ID NO：1的核苷酸序列并在前列腺癌细胞中过表达HNF-3α的HNF-3α的基因的表达载体，其中所述表达载体是病毒载体，例如腺病毒载体 其中HNF-3α的过度表达诱导线粒体细胞色素C释放在前列腺癌细胞的细胞质中，这是细胞凋亡的特征。
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公开(公告)号：KR101974435B1
公开(公告)日：2019-05-02
申请号：KR1020170145219
申请日：2017-11-02
Applicant: 전남대학교산학협력단
Inventor： 이귀숙
IPC: A61K31/4725 , A23L33/10
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公开(公告)号：KR1020100119350A
公开(公告)日：2010-11-09
申请号：KR1020090038430
申请日：2009-04-30
Applicant: 전남대학교산학협력단
Inventor： 이귀숙
CPC classification number: A61K38/43 , A61K38/1796
Abstract: PURPOSE: An ARR19(androgen receptor corepressor-19kDa) in sexual gonad is provided to suppress testosterone synthesis and StAR, 3β-HSD, P450scc, and P450c17 protein expression. CONSTITUTION: An ARR19 for suppressing steroid synthesis suppresses steroid synthesis in animal sexual gonad. The suppression of steroid synthesis suppresses StAR, 3β-HSD, P450scc or P450c17 protein expression which is an enzyme relating steroid synthesis. ARR 19 is expressed in male reproductive organ such as testis and prostate and is cloned in a mouse cDNA library by screening.
Abstract translation: 目的：提供性腺中的ARR19（雄激素受体抑制因子-19kDa）以抑制睾酮合成和StAR，3β-HSD，P450scc和P450c17蛋白表达。 构成：用于抑制类固醇合成的ARR19抑制动物性腺中的类固醇合成。 抑制类固醇合成抑制StAR，3β-HSD，P450scc或P450c17蛋白表达，其是与类固醇合成相关的酶。 ARR19在雄性生殖器官如睾丸和前列腺中表达，并通过筛选克隆到小鼠cDNA文库中。
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公开(公告)号：KR101029251B1
公开(公告)日：2011-04-18
申请号：KR1020090054331
申请日：2009-06-18
Applicant: 전남대학교산학협력단
Abstract: 본 발명은 타액에 포함되어 있는 코티졸(cortisol) 농도를 측정하여 코티졸 일주기리듬의 정상 여부를 판별하는 지표 및 타액내 코티졸의 농도를 기준으로 한 코티졸 일주기리듬 평가 방법에 관한 것으로, 상세하게, 1일을 기준으로 기상직후, 기상후 30분 및 취침직전의 타액내 코티졸 농도인 기상코티졸 농도, CAR코티졸 농도 및 취침코티졸 농도를 측정하고, 기상코티졸 농도, CAR코티졸 농도, 취침코티졸 농도, 기상코티졸 농도를 기준한 CAR코티졸 농도의 증가량, CAR코티졸 농도를 기준한 취침코티졸 농도의 감소량, 기상코티졸 농도를 기준한 CAR코티졸 농도의 증가 백분율 및 CAR코티졸 농도를 기준한 취침코티졸 농도의 감소 백분율에서 하나 이상 선택된 인자를 이용하여 코티졸의 일주기리듬(diurnal rhythm) 정상 여부를 평가하는 방법에 관한 것이다.
코티졸, 부신, 타액, CAR(cortisol awakening response), 호르몬, 일주기리듬-
公开(公告)号：KR1020100136132A
公开(公告)日：2010-12-28
申请号：KR1020090054331
申请日：2009-06-18
Applicant: 전남대학교산학협력단
Abstract: PURPOSE: An index and method for evaluating normality of cortisol diurnal rhythm by measuring cortisol concentration in saliva is provided to determine cortisol-associated diseases or diseases causing stress. CONSTITUTION: An index for evaluating cortisol diurnal rhythm comprises: a wake-up index which is the concentrate of salivary cortisol right after wake up; a CAR index which is the concentration of salivary cortisol by cortisol awakening response; a sleep index which is the concentration of salivary cortisol right before sleeping; a CAR increase index; a CAR reduction index; a CAR increase rate index; and a CAR reduction rate index.
Abstract translation: 目的：提供通过测量唾液中皮质醇浓度来评估皮质醇昼夜节律正常的指标和方法，以确定皮质醇相关疾病或引起压力的疾病。 构成：评估皮质醇昼夜节律的指标包括：唤醒指数，即唤醒后唾液皮质醇的浓缩液; CAR指数，其是通过皮质醇觉醒反应的唾液皮质醇的浓度; 睡眠指数是睡眠前唾液皮质醇的浓度; CAR增加指数; CAR减少指数; 汽车增长率指数; 和减速率指数。
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