公开(公告)号：KR100894832B1

公开(公告)日：2009-04-24

申请号：KR1020070107775

申请日：2007-10-25

Applicant: 한국과학기술연구원

Inventor： 함정엽 ,  안홍열 ,  박영희 ,  김수남 ,  이우정 ,  양현옥 ,  권학철

IPC: C07C39/17 ,  C07C39/18 ,  C07C39/205

Abstract: A stilbene derivatives as PPAR(peroxisome proliferator activation acceptor) alpha/gamma dual agonists is provided for treatment and prevention of obesity, diabetes, skin aging, skin wrinkle and skin hydration. A stilbene derivatives represented by the formula 1 is obtained by reacting a compound represented by the formula 2 and a compound represented by the formula 3. In the formula 1, 2 and 3, R^1 indicates an isoflavonoid group represented by the formula 1-a; R^2 is hydrogen, methyl, ethyl, tert-butyl, benzyl, methoxymethyl, trimethylsilyl, tert-butyldiphenylsilyl, tert-butyldimethylsilyl or triisopropylsilyl; R^3 shows -F, -CF3, -CH3 or -OCH3; A represents cis-, trans- isomers; m is an integer of 0~2; n is an integer of 1~5; p is integer of 0~2; and X shows a halogen atom.

Abstract translation: 提供作为PPAR（过氧化物酶体增殖物激活受体）α/γ双重激动剂的二苯乙烯衍生物用于治疗和预防肥胖症，糖尿病，皮肤老化，皮肤皱纹和皮肤水合。 由式1表示的芪衍生物通过使式2表示的化合物与由式3表示的化合物反应而获得。在式1,2和3中，R 1表示由式1表示的异黄酮基， 一个; R 2是氢，甲基，乙基，叔丁基，苄基，甲氧基甲基，三甲基甲硅烷基，叔丁基二苯基甲硅烷基，叔丁基二甲基甲硅烷基或三异丙基甲硅烷基; R 3表示-F，-CF 3，-CH 3或-OCH 3; A代表顺式，反式异构体; m为0〜2的整数; n为1〜5的整数; p为0〜2的整数; X表示卤素原子。