公开(公告)号：KR1020130082048A

公开(公告)日：2013-07-18

申请号：KR1020120031828

申请日：2012-03-28

Applicant: 한국과학기술연구원

Inventor： 강기성 ,  김수남 ,  함정엽 ,  이우정 ,  야마베노리꼬 ,  이지환

IPC: A61K36/258 ,  A61P13/12

CPC classification number: A61K36/258 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K31/198 ,  A61K31/704

Abstract: PURPOSE: A therapeutic composition is provided to be able to be effectively used in prevention, alleviation or treatment of kidney diseases as the Panax species plant extract or the product of the Maillard type browning reaction with glucose amino acid have an excellent removal ability of active oxygen, and remarkably excellent activation to suppress damage of kidney epithelial cell due to the oxidative stress. CONSTITUTION: A pharmaceutical composition for prevention or treatment of kidney diseases comprises ginsenoside Re, Panax species plant extract including ginsenoside Re, or the product of the Maillard browning reaction obtained by reacting ginsenoside-originated saccharide with amino acid at 100-130deg.C, as an active ingredient. A composition for health functional food for prevention or alleviation of kidney diseases includes ginsenoside Re, Panax species plant extract including ginsenoside Re, or the product of the Maillard browning reaction obtained by reacting ginsenoside-originated saccharide with amino acid at 100-130deg.C, as an active ingredient. The Panax species plant is Korean ginseng, Panax quinquefolius, Panax notoginseng, Japanse seng, Panax trifolium, Himalayan ginseng, Panax vietnamensis, their cultured root, or their combination. [Reference numerals] (AA) Ginsenoside Re; (BB) Ginsenoside Rg_2; (CC) Dehydration reaction; (DD) Ginsenoside Rg_6; (EE) Ginsenoside F_4; (FF) Separated glucose + Glycine; (GG) Maillard browning reaction

Abstract translation: 目的：提供治疗组合物，以能够有效地用于预防，减轻或治疗肾脏疾病，因为人参植物提取物或美拉德型褐变反应与葡萄糖氨基酸的产物具有优异的活性氧去除能力 ，并且显着优异的活化以抑制由于氧化应激引起的肾上皮细胞的损伤。 构成：用于预防或治疗肾脏疾病的药物组合物包括人参皂甙Re，人参皂苷Re的人参植物提取物，或将人参皂甙起源的糖与氨基酸在100-130℃下反应获得的美拉德褐变反应的产物，作为 活性成分。 用于预防或减轻肾脏疾病的健康功能食品的组合物包括人参皂苷Re，人参皂苷Re的人参植物提取物，或通过使人参皂甙起源的糖与氨基酸在100-130℃反应而获得的美拉德褐变反应的产物， 作为活性成分。 人参植物是韩国人参，三七，三七，日本人，三七，喜马拉雅，人参，培养根或其组合。 （AA）人参皂甙Re; （BB）人参皂甙Rg_2; （CC）脱水反应; （DD）人参皂甙Rg_6; （EE）人参皂甙F_4; （FF）分离葡萄糖+甘氨酸; （GG）美拉德褐变反应

公开(公告)号：KR101400781B1

公开(公告)日：2014-06-17

申请号：KR1020120031828

申请日：2012-03-28

Applicant: 한국과학기술연구원

Inventor： 강기성 ,  김수남 ,  함정엽 ,  이우정 ,  야마베노리꼬 ,  이지환

IPC: A61K36/258 ,  A61P13/12

Abstract: 본 발명은 진세노사이드 Re, 진세노사이드 Re를 포함하는 파낙스속 식물 추출물, 또는 글루코스를 아미노산과 함께 100 ~ 130℃에서 0.5 ~ 12 시간 반응시켜 얻어진 마이얄형 갈색화 반응 생성물을 유효성분으로 포함하는 신장질환의 예방, 개선 또는 치료용 조성물을 제공한다.

公开(公告)号：KR101455177B1

公开(公告)日：2014-10-30

申请号：KR1020130136547

申请日：2013-11-11

Applicant: 한국과학기술연구원

Inventor： 강기성 ,  김수남 ,  함정엽 ,  이우정 ,  야마베노리꼬 ,  이지환

IPC: A61K31/70 ,  A61K36/258 ,  A61P35/00 ,  A61P13/12

Abstract: 본 발명은 진세노사이드 Re, 진세노사이드 Re를 포함하는 파낙스속 식물 추출물, 또는 글루코스를 아미노산과 함께 100 ~ 130℃에서 0.5 ~ 12 시간 반응시켜 얻어진 마이얄형 갈색화 반응 생성물을 유효성분으로 포함하는 신장질환의 예방, 개선 또는 치료용 조성물을 제공한다.

公开(公告)号：KR1020130125746A

公开(公告)日：2013-11-19

申请号：KR1020130136547

申请日：2013-11-11

Applicant: 한국과학기술연구원

Inventor： 강기성 ,  김수남 ,  함정엽 ,  이우정 ,  야마베노리꼬 ,  이지환

IPC: A61K31/70 ,  A61K36/258 ,  A61P35/00 ,  A61P13/12

Abstract: Provided is a composition for preventing, relieving or treating renal diseases, comprising Maillard browning reaction products as active ingredients wherein the products are acquired by reacting Ginsenoside Re, Panax genus plant extract including Ginsenoside Re, or glucose with an amino acid at 100-130 for 0.5-12 hours. [Reference numerals] (AA) Ginsenoside Re;(BB) Ginsenoside Rg_2;(CC) dehydration;(DD) Ginsenoside Rg_6;(EE) Ginsenoside F_4;(FF) Separated glucose + glycine;(GG) Maillard-type browning reaction

Abstract translation: 提供了用于预防，缓解或治疗肾脏疾病的组合物，其包含美拉德褐变反应产物作为活性成分，其中通过人参皂甙Re，Panax属植物提取物（包括人参皂甙Re）或葡萄糖与100-130的氨基酸反应获得产物 0.5-12小时。 （AA）人参皂甙Re;（BB）人参皂苷Rg_2;（CC）脱水;（DD）人参皂甙Rg_6;（EE）人参皂甙F_4;（FF）分离葡萄糖+甘氨酸;（GG）美拉德型褐变反应