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公开(公告)号：KR1020100082255A
公开(公告)日：2010-07-16
申请号：KR1020090001660
申请日：2009-01-08
Applicant: 한국과학기술연구원
CPC classification number: C07F5/027
Abstract: PURPOSE: A novel potassium haloaryltrifluoroborate derivative compound and a method for preparing the same are provided to use in manufacturing medicine and various organic synthesis reactions. CONSTITUTION: A potassium haloaryltrifluoroborate derivative compound is denoted by chemical formula 1. A method for preparing the potassium haloaryltrifluoroborate derivative compound comprises: a step of mixing dihaloaryl compound of chemical formula 2 and borate compound of B(-OR_2)_3 in a solvent; and a step of adding lithium compound of R_2Li and potassium hydrogen fluoride. The solvent is diethyl ether(Et_2O), tetrahydrofuran, 1,4-dioxane, pentane, hexane, or heptanes. The borate compound is timethylborate(B(-OCH_3)_3), triethylborate(B(-OCH_2CH_3)_3), tripropylborate(B(-OCH_2CH_2CH_3)_3), or triphenylborate(B(-OPh)_3).
Abstract translation: 目的：提供新的卤代卤代三氟硼酸钾衍生物化合物及其制备方法，用于制备药物和各种有机合成反应。 构成：卤代芳基三氟硼酸钾衍生物化合物由化学式1表示。卤代芳基三氟硼酸钾衍生物化合物的制备方法包括：将化学式2的二卤代芳基化合物与B（-OR_2）3的硼酸酯化合物在溶剂中混合的步骤; 以及添加R_2Li和氟化氢钾的锂化合物的步骤。 溶剂是二乙醚（Et 2 O），四氢呋喃，1,4-二恶烷，戊烷，己烷或庚烷。 硼酸盐化合物是硼酸三乙酯（B（-OCH 3）3），硼酸三乙酯（B（-OCH 2 CH 3）3）），三异丙基硼酸盐（B（-OCH 2 CH 2 CH 3）3））或三苯基硼酸盐（B（-OPh）3））。
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公开(公告)号：KR101113791B1
公开(公告)日：2012-02-27
申请号：KR1020090083991
申请日：2009-09-07
Applicant: 한국과학기술연구원
IPC: C07F5/02 , C07F1/06 , C07C247/16
Abstract: 신규한 포타슘 아지도아릴트리플루오로보레이트(Potassium Azidoaryltrifluoroborate) 유도체 및 그 제조방법이 개시된다. 포타슘 아지도아릴트리플루오로보레이트 유도체는 유기합성 반응, 의약품 제조 및 생리활성 천연물 분야 등에서 다양하게 활용 가능하다. 또한, 본 발명에 따른 제조방법은 제조과정이 매우 빠르고, 편리하며 효율적이다.
포타슘 아지도아릴트리플루오로보레이트, 커퍼할라이드, 아릴아자이드 유도체-
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公开(公告)号：KR1020110026196A
公开(公告)日：2011-03-15
申请号：KR1020090083991
申请日：2009-09-07
Applicant: 한국과학기술연구원
IPC: C07F5/02 , C07F1/06 , C07C247/16
CPC classification number: C07F5/027 , B01J23/44 , B01J23/60 , C07C247/16
Abstract: PURPOSE: A method for conveniently and efficiently preparing potassium azidoaryltrifluoroborate derivative is provided. CONSTITUTION: A potassium azidoaryltrifluoroborate derivative has a structure of chemical formula 1. The derivative if prepared by reaction formula 2. The method comprises a step of mixing potassium haloaryltrifluorobotate derivative, sodium azide(NaN_3), copper halide(CuX), amine ligand, and inorganic salt. The inorganic salt is sodium carbonate(Na_2CO_3), potassium carbonate(K_2CO_3), cesium carbonate(Cs_2CO_3), magnesium carbonate(MgCO_3), or calcium carbonate(CaCO_3).
Abstract translation: 目的：提供方便，有效地制备叠氮基芳基三氟硼酸钾衍生物的方法。 构成：叠氮基芳基三氟硼酸钾衍生物具有化学式1的结构。该衍生物如通过反应式2制备。该方法包括将卤代芳基三氟硼酸钾衍生物，叠氮化钠（NaN 3），卤化铜（CuX），胺配体和 无机盐。 无机盐是碳酸钠（Na 2 CO 3），碳酸钾（K 2 CO 3），碳酸铯（Cs 2 CO 3），碳酸镁（MgCO 3）或碳酸钙（CaCO 3）。
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