公开(公告)号：WO1994026904A1

公开(公告)日：1994-11-24

申请号：PCT/US1994005090

申请日：1994-05-09

Applicant: ABBOTT LABORATORIES ,  UNIVERSITY OF GLASGOW

Inventor： ABBOTT LABORATORIES ,  UNIVERSITY OF GLASGOW ,  CARMAN, William ,  DECKER, Richard, H. ,  WALLACE, Lesley ,  MIMMS, Larry, T. ,  SOLOMON, Larry, R.

IPC: C12N15/51

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K2319/40 ,  C07K2319/61 ,  C12N2730/10122 ,  Y10S435/975 ,  Y10S436/82

Abstract: Mutant Hepatitis B Virus (HBV) nucleic acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HBV nucleic acid sequences, HBV immunogenic particles, and a method for producing antibodies to HBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HBV nucleic acid sequences.

Abstract translation: 用于各种诊断和治疗应用的突变型乙型肝炎病毒（HBV）核酸序列，使用HBV核酸序列的试剂盒，HBV免疫原性颗粒和用于产生针对HBV的抗体的方法。 还提供了从HBV核酸序列产生抗体，多克隆或单克隆抗体的方法。

公开(公告)号：WO1996004249A1

公开(公告)日：1996-02-15

申请号：PCT/US1995009611

申请日：1995-07-31

Applicant: SRI INTERNATIONAL ,  UNIVERSITY OF GLASGOW ,  CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED

Inventor： SRI INTERNATIONAL ,  UNIVERSITY OF GLASGOW ,  CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED ,  TRACY, Michael ,  KELSON, Andrew, B. ,  WORKMAN, Paul ,  LEWIS, Alexander, D. ,  ABOAGYE, Eric, O.

IPC: C07D233/91

CPC classification number: C07H13/04 ,  A61K49/06 ,  C07D233/91 ,  C07H15/04

Abstract: Novel agents useful for detecting hypoxic tumor cells are provided. The compounds have structural formula (I), wherein R and R2 are as defined herein. Methods of using the compounds to detect hypoxic tumor cells are also provided, as are pharmaceutical compositions formulated with the novel compounds.

Abstract translation: 提供了可用于检测缺氧性肿瘤细胞的新型药剂。 化合物具有结构式（I），其中R 1和R 2如本文所定义。 还提供了使用化合物来检测缺氧性肿瘤细胞的方法，以及用新化合物配制的药物组合物。