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1.发明申请METHODS FOR ENHANCING LIFESPAN AND/OR TREATING CELLULAR PROLIFERATIVE DISORDERS BY TRANSPLANTATION 审中-公开通过移植增强寿命和/或治疗细胞增殖性疾病的方法
公开(公告)号：WO2018052964A1
公开(公告)日：2018-03-22
申请号：PCT/US2017/051310
申请日：2017-09-13
Applicant: ACADEMIA SINICA , SHEN, Che-Kun James , SHYU, Yu-Chiau , HUNG, Chun-Hao
Inventor： SHEN, Che-Kun James , SHYU, Yu-Chiau , HUNG, Chun-Hao
Abstract: The invention found that first, the feasibility of transfer of tumor resistance and other healthy longevity characters through transplantation of bone marrow mononuclear cells (BMMNC) or hematopoietic stem cells (HSC)/hematopoietic stem and progenitor cells (HSPC) consisting of genetically engineered EKLF gene encoding the hematopoietic transcription factor EKLF. Secondly, the present invention demonstrates expression of EKLF in the long-term hematopoietic stem cells (LT-HSC), and thus EKLF as a target of regulation of hematopoiesis.
Abstract translation: 本发明首先通过移植骨髓单个核细胞（BMMNC）或造血干细胞（HSC）/造血干细胞和祖细胞（以下简称“造血干细胞”）转移肿瘤抗性和其他健康长寿特征 HSPC）由编码造血转录因子EKLF的基因工程EKLF基因组成。 其次，本发明展示了EKLF在长期造血干细胞（LT-HSC）中的表达，并且因此表明EKLF作为造血调节的靶标。
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2.发明申请ANIMAL MODEL OF LONGEVITY AND RELATED METHODS FOR INCREASING LONGEVITY AND INHIBITING TUMORIGENESIS 审中-公开长期动物模型和相关方法增加长势和抑制肿瘤发生
公开(公告)号：WO2016036727A1
公开(公告)日：2016-03-10
申请号：PCT/US2015/047917
申请日：2015-09-01
Applicant: ACADEMIA SINICA
Inventor： SHEN, Che-Kun James , SHYU, Yu-Chiau
CPC classification number: C07K14/4702 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0331 , A61K38/1709 , A61K45/06 , C07K14/4703 , Y02A50/402
Abstract: The present invention includes a genetically-modified non-human animal model of longevity and increased health span, which is associated with reduced tumorigenesis and tumor metastasis, as well as related methods for increasing longevity and health span, reducing tumorigenesis and tumor metastasis, and identifying active agents that confer increased longevity or health span, or reduced tumorigenesis or tumor metastasis
Abstract translation: 本发明包括一种遗传修饰的非人类动物模型，其寿命延长，健康范围增加，其与减少的肿瘤发生和肿瘤转移相关，以及相关的增加寿命和健康跨度，减少肿瘤发生和肿瘤转移的方法，以及鉴定 增加寿命或健康范围，或减少肿瘤发生或肿瘤转移的活性剂
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3.发明公开
公开(公告)号：EP3512538A1
公开(公告)日：2019-07-24
申请号：EP17851436.0
申请日：2017-09-13
Applicant: Academia Sinica , Shen, Che-Kun James , Shyu, Yu-Chiau , Hung, Chun-Hao
Inventor： SHEN, Che-Kun James , SHYU, Yu-Chiau , HUNG, Chun-Hao
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4.发明公开ANIMAL MODEL OF LONGEVITY AND RELATED METHODS FOR INCREASING LONGEVITY AND INHIBITING TUMORIGENESIS 审中-公开提高生活能力和抑制肿瘤生长的长效动物模型及相关方法
公开(公告)号：EP3188600A1
公开(公告)日：2017-07-12
申请号：EP15837670.7
申请日：2015-09-01
Applicant: Academia Sinica
Inventor： SHEN, Che-Kun James , SHYU, Yu-Chiau
CPC classification number: C07K14/4702 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0331 , A61K38/1709 , A61K45/06 , C07K14/4703 , Y02A50/402
Abstract: The present invention includes a genetically-modified non-human animal model of longevity and increased health span, which is associated with reduced tumorigenesis and tumor metastasis, as well as related methods for increasing longevity and health span, reducing tumorigenesis and tumor metastasis, and identifying active agents that confer increased longevity or health span, or reduced tumorigenesis or tumor metastasis.
Abstract translation: 本发明包括经遗传修饰的长寿和增加的健康跨度的非人动物模型，其与减少的肿瘤发生和肿瘤转移相关，以及用于增加寿命和健康跨度，减少肿瘤发生和肿瘤转移的相关方法，以及鉴定 赋予增加的寿命或健康跨度的活性剂，或减少的肿瘤发生或肿瘤转移
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