公开(公告)号：US3639306A

公开(公告)日：1972-02-01

申请号：US3639306D

申请日：1968-08-08

Applicant: AMICON CORP

Inventor： STERNBERG SHMUEL ,  BIXLER HARRIS J ,  MICHAELS ALAN S

IPC: B01J13/14 ,  A01N25/28 ,  A61K9/16 ,  A61K9/22 ,  B01D67/00 ,  B01J13/02 ,  B01J13/08 ,  C08J9/28 ,  C12N11/04 ,  C08J1/28

CPC classification number: B01D69/141 ,  B01J13/08 ,  C08J9/28 ,  C08J2201/0544 ,  C12N11/04 ,  Y10S71/903 ,  Y10S71/904 ,  Y10T428/2987 ,  Y10T428/2989 ,  Y10T428/2998

Abstract: ANISOTROPIC POLYMER PARTICLES COMPRISING A THIN SKIN WHICH FORMS EITHER A MIXROPOROUS OR DIFFUSIVE BARRIER LAYER AND A SUBSTANTIALLY HOLLOW INTERIOR WHICH INTERIOR, HOWEVER, COMPRISES SUFFICIENT MACROPOROUS POLYMER SUPPORT STRUCTURE TO SUBSTANTIALLY ENHANCE THE PHYSICAL STRENGTH, PARTICULARLY THE RESISTANCE TO COMPRESSION, OF THE PARTICLES. THESE PARTICLES HAVE EXCELLENT UTILITY FOR ENCAPSULATING VARIOUS MATERIALS FOR CONTROLLED RELEASE

THEREFROM, FOR IMMOBILIZING SOME CHEMICAL REACTANTS WHILE ALLOWING FREE ACCESS AND EGRESS OF OTHER REACTANTS OR REACTION PRODUCTS FROM THE PARTICLE, AND FOR EFFECTING SEPARATIONS BSED ON DIFFUSION OF DIFFERENT-SIZE MOLECULES THERETHROUGH. THE VERSATILE PROCESS BY WHICH THESE PARTICLES ARE FORMED IS ALSO A SUBJECT OF THE INSTANT INVENTION.

公开(公告)号：US3598728A

公开(公告)日：1971-08-10

申请号：US3598728D

申请日：1969-06-16

Applicant: AMICON CORP

Inventor： BIXLER HARRIS J ,  STERNBERG SHMUEL

IPC: B01D61/38 ,  B01D63/00 ,  B01D13/00 ,  B01D31/00

CPC classification number: B01D61/38 ,  B01D61/145 ,  B01D63/065 ,  B01D69/02

Abstract: A NOVEL SEPARATIVE APPARATUS COMPRISING A SEPARATION ZONE WHEREBY (1) AN IMMOBILIZED LIQUID PHASE IS SEPARATED FROM A MOBILE LIQUID PHASE BY A SEMI-PERMEABLE MEMBRANE AND WHEREIN SAID MOBILE LIQUID PHASE IS A CARRIER LIQUID FOR A PLURALITY OF COMPOUNDS, AT LEAST ONE OF WHICH COMPOUNDS INTERACTS, CHEMICALLY OR PHYSICALLY, WITH THE SEMI-PERMEABLE MEMBRANE AND/OR THE IMMOBILIZED LIQUID PHASE AND IS THEREBY RETARDED IN ITS PROGRESS THROUGH THE REACTION ZONE.

公开(公告)号：DE1939066A1

公开(公告)日：1970-02-12

申请号：DE1939066

申请日：1969-07-31

Applicant: AMICON CORP

Inventor： STERNBERG SHMUEL ,  JACOB BIXLER HARRIS ,  SHERMAN MICHAELS ALAN

IPC: B01J13/14 ,  A01N25/28 ,  A61K9/16 ,  A61K9/22 ,  B01D67/00 ,  B01J13/02 ,  B01J13/08 ,  C08J9/28 ,  C12N11/04

Abstract: 1,232,153. Chromatographic substrate. AMICON CORP. 1 Aug., 1969 [8 Aug., 1968], No. 38701/69. Heading B1X. [Also in Divisions B8 and C3] Particles formed of a continuous phase organic polymer having a microporous outer barrier skin of 0.1-0.5 microns in thickness and pores of 1-500 millimicrons in diameter and a macroporous core with a structure which supports the skin, the particle having a void volume of at least 25% volume of the particle (see Division C3) are used as an adsorbent in liquid chromatography processes. In an example (6) two batches of spherical particles of average diameter 2 mms. are prepared from vinyl chloride/acrylonitrile copolymer and placed in two columns arranged for sequential flow. A sample of a solution of gamma globulin, albumin, ovalbumin, phenylalamine and Cytochrome C in a phosphate buffer is fed to the first column and a solution of phosphate buffer and isotonic saline circulated. The material leaving the downstream column is analyzed by a u.v. spectrometer and a separation of gamma globulin from albumin noted. Reference is made to the possible use of ion exchange resins as the polymers from which the particles are formed.

公开(公告)号：CA900288A

公开(公告)日：1972-05-16

申请号：CA900288D

Applicant: AMICON CORP

Inventor： STERNBERG SHMUEL ,  MICHAELS ALAN S ,  BIXLER HARRIS J

IPC: B01J13/02 ,  B01J13/08 ,  C08J9/28 ,  C12N11/04