公开(公告)号：DE59906669D1

公开(公告)日：2003-09-25

申请号：DE59906669

申请日：1999-12-22

Applicant: BASF AG

Inventor： LOCKEMANN DR ,  LUEDDECKE DR ,  HORN DR

IPC: A61J3/02 ,  B01J2/00 ,  B01J2/04 ,  B01J3/00 ,  B01J13/06 ,  B01J19/00

Abstract: Preparation of stable fine particle powders comprises: (a) dissolving one or more substances (A) and one or more substances (B) in a super-critical, compressible fluid; and (b) relaxing the fluid along a residence path, where the solubility limit of (A) is earlier than that of (B) in the residence path. An Independent claim is included for an apparatus for carrying out the process comprising a first high pressure autoclave (2) for dissolving substance (A) in a super critical fluid and a second high pressure autoclave for dissolving substance (B) in a super critical fluid. Two separate feeds (3, 7) connected to relaxation devices (4, 8) relax both fluids so that their flows intersect.

公开(公告)号：DE59509746D1

公开(公告)日：2001-11-29

申请号：DE59509746

申请日：1995-12-19

Applicant: BASF AG

Inventor： RIEDE DR ,  GOEBEL WERNER ,  LOCKEMANN DR

IPC: A61K9/107 ,  A01N25/04 ,  A61K9/10 ,  A61K9/127 ,  A61K38/17 ,  B01F23/00 ,  B01F23/70 ,  B01F23/80 ,  B01J13/00 ,  C09B67/44 ,  C09B67/46 ,  C09K3/00

Abstract: Prodn. of a dispersion contg. an active agent (I) comprises (a) dissolving (I) in a fluid gas; and either (bi) dissolving the soln. completely in another liq.; and (bii) releasing the pressure: or (c1) forming a dispersion of the soln. in a liq. satd. with the gas; (cii) passing through a dwell zone to form a second dispersion; and (ciii) releasing the pressure; or (d1) releasing the pressure to form a fine dispersion of (I) in (II); (dii) dispersing in a second fluid; and (diii) passing through a dwell zone and separating into a gas phase and a dispersion.