公开(公告)号：US20220259580A1

公开(公告)日：2022-08-18

申请号：US17416480

申请日：2019-12-09

Applicant: BASF SE

Inventor： Kai-Uwe Baldenius ,  Michael Breuer ,  Corinna Ruffer ,  Melanie Weingarten ,  Reinhard Zschoche ,  Stefan Seemayer ,  Bernd Nidetzky ,  Katharina Schmoelzer ,  Michael Puhl

IPC: C12N9/24 ,  C12P19/14 ,  C12P19/18 ,  C12N1/20

Abstract: The present disclosure relates to methods for producing human milk oligosaccharide (HMO) core structures using glycosidases from family GH20 hexosaminidases. In particular, the present disclosure provides methods for producing lacto-N-triose II (LNT II) and/or lacto-N-tetraose (LNT) by reacting glucosamine-oxazoline and/or lacto-N-biose-oxazoline with lactose catalysed by an enzyme of the glycoside hydrolase family 20 (GH20) according to the classification of the Carbohydrate-Active-Enzymes (CAZy) database. Specific optimized enzymes are identified to catalyse the reactions.

公开(公告)号：US20200048294A1

公开(公告)日：2020-02-13

申请号：US16393859

申请日：2019-04-24

Applicant: BASF SE

Inventor： Giovanni Cipolletti ,  Gessica Laudati ,  Liana Salsini ,  Michael Puhl

IPC: C07H3/06 ,  C07H1/00 ,  A23L33/125

Abstract: This invention describes new hydrated and anhydrous polymorphs of 2′-0-ficosyllactose (2′FL): Polymorph A 2′FL-3/2H2O, Polymorph B 2TL-5/2H2O and anhydrous Polymorph C. There is also a description of the methods for obtaining them, and of a new method for preparing Polymorph I already known in the literature.

公开(公告)号：US11414449B2

公开(公告)日：2022-08-16

申请号：US16393866

申请日：2019-04-24

Applicant: BASF SE

Inventor： Giovanni Cipolletti ,  Gessica Laudati ,  Liana Salsini ,  Michael Puhl

IPC: C07H3/06 ,  C07H1/00 ,  A23L33/125

Abstract: This invention describes new hydrated and anhydrous polymorphs of 2′-O-fucosyllactose (2′FL): Polymorph A 2′FL-3/2H2O, Polymorph B 2TL-5/2 H2O and anhydrous Polymorph C. There is also a description of the methods for obtaining them, and of a new method for preparing Polymorph I already known in the literature.

公开(公告)号：US09061982B2

公开(公告)日：2015-06-23

申请号：US13673278

申请日：2012-11-09

Applicant: BASF SE

Inventor： Hansgeorg Ernst ,  Michael Puhl ,  Stefan Benson ,  Wolfgang Siegel

IPC: C07C45/34 ,  C07C45/28 ,  C07C409/18 ,  C07F9/54 ,  C07C403/08 ,  C07C407/00

CPC classification number: C07C45/28 ,  C07C403/08 ,  C07C407/00 ,  C07C409/18 ,  C07C2601/16 ,  C07F9/5442 ,  Y02P20/55 ,  C07C409/14

Abstract: The present invention relates to the preparation of oxovinylionol and its O-protected derivatives of the formula I in which R is hydrogen or an OH protecting group, for example a group Si(Ra)3, by reacting a compound of the general formula II in which R has the meanings given above for formula I, i.e. β-vinyl ionol (formula II, R=hydrogen) or an O-protected derivative thereof (formula II, R═OH protecting group) with an oxidant in the presence of at least one transition metal, where the oxidant comprises at least one oxygen-containing compound which is selected from among hydrogen peroxide and organic hydroperoxides.

Abstract translation: 本发明涉及通过使通式II的化合物与式（I）的化合物反应制备式I化合物的氧代乙烯基醇及其O-保护的衍生物，其中R是氢或OH保护基，例如Si（Ra） 其中R具有上面给出的式I所示的含义，即在存在下的化合物（即，b） - 乙烯基离子（式II，R =氢）或其被保护的衍生物（式II，R = OH保护基） 至少一种过渡金属，其中氧化剂包含至少一种选自过氧化氢和有机氢过氧化物的含氧化合物。

公开(公告)号：US09056853B2

公开(公告)日：2015-06-16

申请号：US14293288

申请日：2014-06-02

Applicant: BASF SE

Inventor： Thomas Schmidt ,  Michael Puhl ,  Joachim Dickhaut ,  Henricus Maria Martinus Bastiaans ,  Michael Rack ,  Deborah L. Culbertson ,  Douglas D. Anspaugh ,  Franz-Josef Braun ,  Toni Bucci ,  Henry Van Tuyl Cotter ,  David G. Kuhn ,  Hassan Oloumi-Sadeghi

IPC: C07D401/04 ,  C07D409/14 ,  A01N43/84 ,  C07D413/14 ,  A01N43/56 ,  C07D401/14

CPC classification number: C07D401/04 ,  A01N43/56 ,  A01N43/84 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14

Abstract: N-Thio-anthranilamid compounds of formula (I) wherein A is A1 wherein the variables and the indices are as defined per the description, processes for preparing the compounds I, pesticidal compositions comprising compounds I, use of compounds I for the control of insects, acarids or nematodes, and methods for treating, controlling, preventing or protecting animals against infestation or infection by parasites by use of compounds of formula I.

Abstract translation: 式（I）的N-硫代 - 邻氨基苯甲酰胺化合物，其中A是A1，其中变量和指数如说明书所定义，制备化合物I的方法，包含化合物I的杀虫组合物，使用化合物I用于防治昆虫 ，螨虫或线虫，以及通过使用式I化合物治疗，控制，预防或保护动物免受寄生虫感染或感染的方法。

公开(公告)号：US10851128B2

公开(公告)日：2020-12-01

申请号：US16393859

申请日：2019-04-24

Applicant: BASF SE

Inventor： Giovanni Cipolletti ,  Gessica Laudati ,  Liana Salsini ,  Michael Puhl

IPC: C07H3/06 ,  C07H1/00 ,  A23L33/125

Abstract: This invention describes new hydrated and anhydrous polymorphs of 2′-0-ficosyllactose (2′FL): Polymorph A 2′FL-3/2H2O, Polymorph B 2TL-5/2H2O and anhydrous Polymorph C. There is also a description of the methods for obtaining them, and of a new method for preparing Polymorph I already known in the literature.

公开(公告)号：US09204647B2

公开(公告)日：2015-12-08

申请号：US14073369

申请日：2013-11-06

Applicant: BASF SE

Inventor： Steffen Gross ,  Delphine Breuninger ,  Henricus Maria Martinus Bastiaans ,  Wolfgang von Deyn ,  Michael Puhl ,  Karsten Koerber ,  Douglas D. Anspaugh ,  Deborah L. Culberston ,  Hassan Oloumi-Sadeghi

IPC: A01N43/40 ,  A61K31/4439 ,  A01N43/707 ,  C07D401/12 ,  C07D401/14 ,  A01P7/00 ,  A01N43/64 ,  A01N43/56 ,  A01N43/74 ,  A01N47/18 ,  C07D417/14

CPC classification number: A01N43/64 ,  A01N43/56 ,  A01N43/707 ,  A01N43/74 ,  A01N47/18 ,  C07D401/12 ,  C07D401/14 ,  C07D417/14

Abstract: The present invention relates to novel pyrazole compounds of the formulae I and II, to their salts and their N-oxides which can be used for combating or controlling invertebrate pests, in particular arthropod pests. The invention also relates to a method for controlling invertebrate pests by using these compounds. The present invention also relates to seed and to an agricultural and veterinary composition comprising said compounds. wherein A is a pyrazole radical of the formulae A1, A2 or A3 # denotes the binding site to the remainder of formulae I or II; X1 is S, O or NR1a; X2 is OR2a, NR2bR2c, S(O)mR2d; X3 is a lone pair or oxygen; R1, R2 and R3 are, inter alia, hydrogen, and wherein R41, R42, R43, R51, R52, R53, R61, R62, R63, are as defined in claim 1.

Abstract translation: 本发明涉及式I和II的新型吡唑化合物及其盐及其N-氧化物，其可用于防治或控制无脊椎动物害虫，特别是节肢动物害虫。 本发明还涉及通过使用这些化合物来控制无脊椎害虫的方法。 本发明还涉及种子和包含所述化合物的农业和兽医组合物。 其中A是式A1，A2或A3的吡唑基，A3表示与式I或II的其余部分的结合位点; X1是S，O或NR1a; X2是OR2a，NR2bR2c，S（O）mR2d; X3是孤对或氧气; R1，R2和R3尤其是氢，并且其中R41，R42，R43，R51，R52，R53，R61，R62，R63如权利要求1中所定义。

公开(公告)号：US10988499B2

公开(公告)日：2021-04-27

申请号：US16411721

申请日：2019-05-14

Applicant: BASF SE

Inventor： Giovanni Cipolletti ,  Gessica Laudati ,  Liana Salsini ,  Michael Puhl

IPC: C07H3/06 ,  C07H1/00 ,  A23L33/125

Abstract: This invention describes new hydrated and anhydrous polymorphs of 2′-O-fucosyllactose (2′FL): Polymorph A 2′FL-3/2H2O, Polymorph B 2TL-5/2 H2O and anhydrous Polymorph C. There is also a description of the methods for obtaining them, and of a new method for preparing Polymorph I already known in the literature.

公开(公告)号：US09365543B2

公开(公告)日：2016-06-14

申请号：US14739467

申请日：2015-06-15

Applicant: BASF SE

Inventor： Thomas Schmidt ,  Michael Puhl ,  Joachim Dickhaut ,  Henricus Maria Martinus Bastiaans ,  Michael Rack ,  Deborah L. Culbertson ,  Douglas D. Anspaugh ,  Franz-Josef Braun ,  Toni Bucci ,  Henry Van Tuyl Cotter ,  David G. Kuhn ,  Hassan Oloumi-Sadeghi

IPC: C07D401/04 ,  C07D409/14 ,  C07D413/14 ,  A01N43/84 ,  A01N43/56 ,  C07D401/14

CPC classification number: C07D401/04 ,  A01N43/56 ,  A01N43/84 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14

Abstract: N-Thio-anthranilamid compounds of formula (I) wherein A is A1 wherein the variables and the indices are as defined per the description, processes for preparing the compounds I, pesticidal compositions comprising compounds I, use of compounds I for the control of insects, acarids or nematodes, and methods for treating, controlling, preventing or protecting animals against infestation or infection by parasites by use of compounds of formula I.

公开(公告)号：US12168649B2

公开(公告)日：2024-12-17

申请号：US17269080

申请日：2019-08-16

Applicant: BASF SE

Inventor： Melanie Weingarten ,  Wolfgang Siegel ,  Michael Puhl

IPC: C07D311/72 ,  B01J21/16 ,  B01J35/61 ,  B01J37/06

Abstract: The present invention relates to a process for the production of chromanol and 2-methyl-1,4-naphthoquinone derivatives, more specifically to a process for preparing a compound of the general formula (I) or (II) wherein the variables are as defined in the claims and the description.