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公开(公告)号：WO2019006190A1
公开(公告)日：2019-01-03
申请号：PCT/US2018/040125
申请日：2018-06-28
Applicant: BIO-RAD LABORATORIES, INC. , STUMBO, David, P. , CARMAN, George , HOBBS, Steve , MAKAREWICK, Anthony, J., Jr. , SIMONIAN, Smitri , GLADE, David , OEN, Joshua , PRISTINSKI, Denis , DZENITIS, John
Inventor： STUMBO, David, P. , CARMAN, George , HOBBS, Steve , MAKAREWICK, Anthony, J., Jr. , SIMONIAN, Smitri , GLADE, David , OEN, Joshua , PRISTINSKI, Denis , DZENITIS, John
Abstract: Systems and methods for detection of a signal from droplets of an emulsion. An exemplary system may comprise a fluid transporter having a tube with an open end for aspirating droplets, a singulator to arrange the droplets in single file and to space the single-file droplets from one another, and a detection channel in optical communication with a detector configured to detect a signal from droplets. In some embodiments, the singulator may have a channel junction at which a stream of droplets in single file is combined with a stream of spacing fluid, and a tapered spacing channel extending downstream from the channel junction toward the detection channel. In some embodiments, the fluid transporter may suck droplet-containing fluid and spacing fluid through the detection channel from respective sources. In some embodiments, droplets may be subjected to a disaggregation routine before they are passed through the detection channel.
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公开(公告)号：WO2017117462A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/069334
申请日：2016-12-29
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： LING, Yunfeng , STUMBO, David, P. , CARMAN, George , PRISTINSKI, Denis
CPC classification number: G01N15/1429 , G01N15/1404 , G01N15/1434 , G01N15/1459 , G01N2015/1488
Abstract: Systems and methods for detecting and processing signals from particles. In an exemplary method, particles may be passed through a zone of a channel, while the zone is irradiated with light. Interaction of the light with the particles may deflect light and induce photoluminescence. A deflection signal and a photoluminescence signal may be detected from the zone. Particle waveforms may be identified in the deflection signal. At least a subset of the particle waveforms may be double-peak waveforms including a pair of peaks corresponding to a particle entering and exiting the zone. Amplitudes may be obtained from the photoluminescence signal. The amplitudes may correspond to respective particles and their particle waveforms, and at least a subset of the amplitudes may correspond to the double-peak waveforms. Individual particles may be assigned as positive or as negative for an analyte based on the corresponding amplitudes.
Abstract translation: 用于检测和处理来自粒子的信号的系统和方法
在示例性方法中，颗粒可以通过通道的区域，而区域用光照射。 光与颗粒的相互作用可使光偏转并引起光致发光。 可以从该区域检测偏转信号和光致发光信号。 可以在偏转信号中识别粒子波形。 粒子波形的至少一个子集可以是双峰波形，包括对应于进入和离开该区域的粒子的一对峰。 幅度可以从光致发光信号获得。 振幅可以对应于各个粒子及其粒子波形，并且至少一个振幅子集可以对应于双峰波形。 根据相应的幅度，可以将单个粒子分配为正或负分析物。
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公开(公告)号：WO2014121241A1
公开(公告)日：2014-08-07
申请号：PCT/US2014/014516
申请日：2014-02-03
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： CARMAN, George , CAULEY III, Thomas, H. , STUMBO, David, P.
CPC classification number: B01L3/502784 , B01L2200/0647 , B01L2200/0673 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487
Abstract: System, including methods and apparatus, for spacing droplets from each other and for detection of spaced droplets.
Abstract translation: 系统，包括用于将液滴彼此间隔开并用于检测间隔液滴的方法和装置。
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Patent Agency Ranking
公开(公告)号：WO2014121139A1
公开(公告)日：2014-08-07
申请号：PCT/US2014/014294
申请日：2014-01-31
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： PRISTINSKI, Denis , STUMBO, David, P.
CPC classification number: G02B19/0028 , G01N15/1434 , G01N15/1459 , G01N21/645 , G01N35/08 , G01N2015/1006 , G01N2021/6478 , G01N2201/0806 , G02B6/0008 , G02B6/262 , G02B19/0076
Abstract: Detection system comprising an examination region, a one-piece optical element including a focusing portion to concentrate light received from the examination region and a guiding portion to homogenize light received from the focusing portion, and a detector configured to detect homogenized light received from the guiding portion. The optical element, interchangeably termed a concentrator, may collect incident light from a relatively large area and direct it towards a light sensor with a comparatively small active area.
Abstract translation: 检测系统，包括检查区域，一体式光学元件，其包括聚焦部分，用于集中从检查区域接收的光;以及引导部分，用于使从聚焦部分接收的光均匀;以及检测器，被配置为检测从引导 一部分。 可互换地称为聚光器的光学元件可以从相对较大的区域收集入射光并将其引导到具有相对小的有效面积的光传感器。
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公开(公告)号：WO2019006190A8
公开(公告)日：2019-01-03
申请号：PCT/US2018/040125
申请日：2018-06-28
Applicant: BIO-RAD LABORATORIES, INC. , STUMBO, David, P. , CARMAN, George , HOBBS, Steve , MAKAREWICZ, Anthony, J., Jr. , SIMONIAN, Dmitri , GLADE, David , OEN, Joshua , PRISTINSKI, Denis , DZENITIS, John
Inventor： STUMBO, David, P. , CARMAN, George , HOBBS, Steve , MAKAREWICZ, Anthony, J., Jr. , SIMONIAN, Dmitri , GLADE, David , OEN, Joshua , PRISTINSKI, Denis , DZENITIS, John
Abstract: Systems and methods for detection of a signal from droplets of an emulsion. An exemplary system may comprise a fluid transporter having a tube with an open end for aspirating droplets, a singulator to arrange the droplets in single file and to space the single-file droplets from one another, and a detection channel in optical communication with a detector configured to detect a signal from droplets. In some embodiments, the singulator may have a channel junction at which a stream of droplets in single file is combined with a stream of spacing fluid, and a tapered spacing channel extending downstream from the channel junction toward the detection channel. In some embodiments, the fluid transporter may suck droplet-containing fluid and spacing fluid through the detection channel from respective sources. In some embodiments, droplets may be subjected to a disaggregation routine before they are passed through the detection channel.
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公开(公告)号：EP2951559B1
公开(公告)日：2020-07-29
申请号：EP14746906.8
申请日：2014-01-31
Applicant: Bio-rad Laboratories, Inc.
Inventor： PRISTINSKI, Denis , STUMBO, David, P.
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公开(公告)号：EP3645167A1
公开(公告)日：2020-05-06
申请号：EP18823895.0
申请日：2018-06-28
Applicant: Bio-rad Laboratories, Inc. , Stumbo, David, P. , Carman, George , Hobbs, Steve , Makarewick, Anthony, J., Jr. , Simonian, Smitri , Glade, David , Oen, Joshua , Pristinski, Denis , Dzenitis, John
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8.发明公开DETECTION SYSTEM WITH ONE-PIECE OPTICAL ELEMENT 审中-公开DETEKTIONSSYSTEM MIT EINTEILIGEM OPTISCHEM ELEMENT
公开(公告)号：EP2951559A1
公开(公告)日：2015-12-09
申请号：EP14746906.8
申请日：2014-01-31
Applicant: Bio-rad Laboratories, Inc.
Inventor： PRISTINSKI, Denis , STUMBO, David, P.
Abstract: Detection system comprising an examination region, a one-piece optical element including a focusing portion to concentrate light received from the examination region and a guiding portion to homogenize light received from the focusing portion, and a detector configured to detect homogenized light received from the guiding portion.
Abstract translation: 检测系统，包括检查区域，一体式光学元件，其包括聚焦部分，用于集中从检查区域接收的光;以及引导部分，用于使从聚焦部分接收的光均匀;以及检测器，被配置为检测从引导 一部分。
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