公开(公告)号：CA2781255C

公开(公告)日：2017-08-01

申请号：CA2781255

申请日：2010-11-09

Applicant: BIO-RAD LABORATORIES INC

Inventor： WALKER ROGER ,  JARDIN BENEDICTE

IPC: C07K16/18 ,  C40B30/04 ,  G01N33/72

Abstract: Hemoglobin, its variants, and glycated forms of each are determined individually in a multiplex assay that permits correction of the measured level of IIbAI c to account for glycated variants and other factors related to the inclusion of the variants in the sample. New antibodies that are particularly well adapted to the multiplex assay are also provided.

公开(公告)号：AU2017272223A1

公开(公告)日：2018-01-04

申请号：AU2017272223

申请日：2017-12-06

Applicant: BIO-RAD LABORATORIES INC

Inventor： WALKER ROGER ,  LU YABIN ,  DESAI URVEE ,  SHAN DAMING

IPC: G01N33/53 ,  G01N33/543

Abstract: The present invention provides a method for determining whether a subject is suffering from celiac disease by contacting a sample of bodily fluid from the subject, with an antigen formed from a hexamer of a gliadin fusion protein immobilized on a solid support. The gliadin fusion protein of the antigen includes a recombinant deamidated gliadin linked to a tag such as Glutathione-S transferase (GST) protein. The antigen is prepared by immobilizing the gliadin fusion protein on the solid support. The antigen can further include tissue Transglutaminase (tTG) cross-linked to the gliadin fusion protein. When tTG is present, the tTG and recombinant deamidated gliadin are mixed together prior to immobilization to the solid phase. 9765390_1 (GHMatters) P97180.AU.1

公开(公告)号：AU2017200733A1

公开(公告)日：2017-02-23

申请号：AU2017200733

申请日：2017-02-03

Applicant: BIO-RAD LABORATORIES INC

Inventor： WALKER ROGER ,  JARDIN BENEDICTE

IPC: G01N33/53 ,  C07K16/18 ,  G01N33/72

Abstract: Hemoglobin, its variants, and glycated forms of each are determined individually in a multiplex assay that permits correction of the measured level of HbAi to account for 5 glycated variants and other factors related to the inclusion of the variants in the sample. New antibodies that are particularly well adapted to the multiplex assay are also provided. 8670427_1 (GHMatters) P90472.AU.1

公开(公告)号：EP3066122A4

公开(公告)日：2017-07-19

申请号：EP14860426

申请日：2014-11-05

Applicant: BIO-RAD LABORATORIES INC

Inventor： FLANAGAN JOHN ,  WALKER ROGER ,  DU PATY EMILIE ,  GALEA PASCALE ,  RIEUNIER FRANCOIS ,  LAUNE DANIEL

IPC: C07K16/00 ,  A61K39/00 ,  A61K39/395 ,  C07K16/18 ,  C07K17/00 ,  C07K17/14 ,  C12P21/08 ,  G01N33/577

CPC classification number: G01N33/577 ,  C07B2200/11 ,  C07K16/18 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/92 ,  G01N2333/47

Abstract: Antibodies, and antibody pairs, that bind and specifically detection pre-Haptoglobin-2, and methods for their use, are provided.

Abstract translation: 提供了结合并特异性检测前触珠蛋白-2的抗体和抗体对及其使用方法。