公开(公告)号：WO1988007834A1

公开(公告)日：1988-10-20

申请号：PCT/US1988001068

申请日：1988-04-08

Applicant: BIOMAGNETIC TECHNOLOGIES, INC.

Inventor： BIOMAGNETIC TECHNOLOGIES, INC. ,  CRUM, Duane, B. ,  WESTLEY, Ronald, C. ,  GREENBLATT, Richard, E. ,  TOUSSAINT, Robert, M. ,  HIRSCHKOFF, Eugene, C.

IPC: A61B05/05

CPC classification number: A61B5/04008 ,  G01R33/00

Abstract: Apparatus (10) for making biomagnetic measurements includes a biomagnetometer (18) for measuring magnetic fields produced by the body and an electromagnetic location measurement and recording system (20 and 30) for automatically determining the location of the portion of the body (12) from which the magnetic signals are being gathered. The electromagnetic location recording system permits establishing a real time body frame of reference with respect to the biomagnetometer, so that biomagnetic signals can be correlated directly with body location and structure. The electromagnetic location recording system may be operated continuously at radiation wavelengths which do not interfere with the taking of data, or intermittently with the taking of biomagnetic data, to avoid interference with the measured values of the biomagnetic data. The elements of the electromagnetic location recording system have substantially no residual magnetism when the location recording system is not operating, as the biomagnetic signals are typically so small that even normal residual magnetism might be erroneously recorded as a biomagnetic signal.

公开(公告)号：WO1998029669A3

公开(公告)日：1998-07-09

申请号：PCT/US1997022984

申请日：1997-12-29

Applicant: BIOMAGNETIC TECHNOLOGIES, INC.

Inventor： BIOMAGNETIC TECHNOLOGIES, INC. ,  DiIORIO, Mark, S. ,  YANG, Kai-Yueh ,  YOSHIZUMI, Shozo

IPC: F17C11/00

公开(公告)号：WO1995000858A1

公开(公告)日：1995-01-05

申请号：PCT/US1994006768

申请日：1994-06-21

Applicant: BIOMAGNETIC TECHNOLOGIES, INC.

Inventor： BIOMAGNETIC TECHNOLOGIES, INC. ,  BUCHANAN, D., Scott ,  WARDEN, Laurence ,  RILEY, Scott, W. ,  JOHNSON, Richard, T. ,  BRIMHALL, K., Randy ,  ESSER, Keith, A.

IPC: G01R33/02

CPC classification number: G01R33/0358 ,  A61B5/0046 ,  A61B5/04005

Abstract: A biomagnetometer includes a magnetic field sensor including a magnetic field pickup coil (210) and a detector (211) of small electrical currents flowing within the pickup coil. A vacuum-tight enclosure (212) surrounds the sensor. The enclosure has a concavely upwardly curved first wall, with the magnetic field pickup coil located adjacent to the first wall. A vented reservoir (220) of liquefied gas is located within the enclosure, and a solid thermal conductor (218) extends from the sensor. There is a vacuum-tight thermal feedthrough by which the solid thermal conductor passes between the interior and the exterior of the enclosure. Electronic circuitry for filtering and amplifying the signals of the detector is also provided. Such a biomagnetometer is placed below the body of a reclining subject, and a second portion of the biomagnetometer can be placed above the body. In one form, the enclosures are shaped to form a cavity that receives the head of the subject therein, to achieve full head coverage of the pickup coils in the biomagnetometer.

Abstract translation: 生物仪表包括磁场传感器，其包括在拾取线圈内流动的小电流的磁场拾取线圈（210）和检测器（211）。 真空密封外壳（212）围绕传感器。 外壳具有凹入向上弯曲的第一壁，磁场拾取线圈位于第一壁附近。 液体气体的排放的储存器（220）位于外壳内，并且固体导热体（218）从传感器延伸。 存在真空密封的馈热通道，固体热导体通过其进入外壳的内部和外部之间。 还提供了用于滤波和放大检测器的信号的电子电路。 这样的生物计量器放置在倾斜对象的身体下方，并且生物计量器的第二部分可以放置在身体上方。 在一种形式中，外壳被成形为形成容纳主体的头部的空腔，以实现生物计量器中的拾取线圈的全头覆盖。

公开(公告)号：WO1991002259A1

公开(公告)日：1991-02-21

申请号：PCT/US1990004171

申请日：1990-07-30

Applicant: BIOMAGNETIC TECHNOLOGIES, INC.

Inventor： BIOMAGNETIC TECHNOLOGIES, INC. ,  HINSHAW, Waldo, S. ,  PAULSON, Douglas, N. ,  BUCHANAN, David, Scott ,  HIRSCHKOFF, Eugene, C. ,  DiIORIO, MARK, S. ,  BLACK, William, C., Jr.

IPC: G01R33/035

CPC classification number: G01R33/0358 ,  A61B5/04008 ,  Y10S505/846

Abstract: A biomagnetometer (10) has a magnetic pickup coil (12) positioned remotely from a detector (30). The detector (30) is made form a low-temperature superconductor, while in one approach the pickup coil (12) and an electrical connector (56) between the detector (30) and the pickup coil (12) are made of a high-temperature superconductor. In another approach, an inductive coupler (116') connects the detector (30') and the pickup coil (12'). Although the detector (12) is maintained in a dewar (32) at a sufficiently low temperature to reduce electronic noise, the pickup coil (12) and the connection means need only be maintained at a temperature at which they are superconducting. The resulting biomagnetometer (10) permits the pickup coil (12) to be moved and positioned easily, and to be changed readily.

公开(公告)号：WO1988007835A1

公开(公告)日：1988-10-20

申请号：PCT/US1988001069

申请日：1988-04-08

Applicant: BIOMAGNETIC TECHNOLOGIES, INC.

Inventor： BIOMAGNETIC TECHNOLOGIES, INC. ,  CRUM, Duane, B. ,  WESLEY, Ronald, C. ,  GREENBLATT, Richard, E. ,  TOUSSAINT, Robert, M. ,  HIRSCHKOFF, Eugène, C.

IPC: A61B05/05

CPC classification number: F17C3/085 ,  A61B5/04005 ,  F17C2203/0391 ,  F17C2203/0631 ,  F17C2203/0663 ,  F17C2209/228 ,  F17C2221/017 ,  F17C2223/0161 ,  F17C2270/0509 ,  F17C2270/0536 ,  G01R33/0358

Abstract: Apparatus (12) for performing sensitive magnetic measurements using cryogenically cooled instrumentation (72), wherein the instrumentation (72) is separated from the bubbles present in a cryogenic cooling fluid. In one embodiment, the magnetic measurement instrumentation (72) is placed in a tail piece (31) joined by heat conducting bolts (64) to a dewar (30) containing a cryogenic fluid, and heat from the instrumentation is conducted to the cryogenic fluid heat sink by metallic strips (70) reaching to the bolts (64). The cryogenic fluid does not contact the instrumentation (72) directly, resulting in a significantly reduced level of noise in the instrumentation (72). The tail piece (31) may also be evacuated to avoid pressure and temperature variations that may cause noise and affect the magnetic instrumentation (72).

公开(公告)号：WO1997005823A1

公开(公告)日：1997-02-20

申请号：PCT/US1996012537

申请日：1996-08-05

Applicant: BIOMAGNETIC TECHNOLOGIES, INC.

Inventor： BIOMAGNETIC TECHNOLOGIES, INC. ,  KYNOR, David, B.

IPC: A61B05/05

CPC classification number: A61B5/0452 ,  A61B5/04007 ,  Y10S128/901

Abstract: A measured magnetocardiography signal has a relatively small heart signal mixed with a large noise signal. To produce a heart signal having a reduced noise content, the times of occurrence of a time series of isoelectric intervals (54) of the measured signal is first determined (42) and a time series isoelectric artifact curve is formed from the measurements made at those times of occurrence (44). A time series non-isoelectric artifact curve for other times is determined from this information. The time series isoelectric and non-isoelectric artifact curve is subtracted from the measured cardiography time series signal (46) to yield a time series heart amplitude signal having reduced noise and undistorted form.

Abstract translation: 测量的心电图信号具有与大噪声信号混合的相对较小的心脏信号。 为了产生具有降低的噪声含量的心脏信号，首先确定测量信号的等电位间隔（54）的时间序列的出现次数（42），并根据这些测量形成时间序列等电赝像曲线 发生次数（44）。 根据该信息确定其他时间的时间序列非等电赝像曲线。 从测量的心电图时间序列信号（46）中减去时间序列等电点和非等电赝像曲线，以产生具有降低的噪声和未失真形式的时间序列心脏振幅信号。

公开(公告)号：WO1994003754A1

公开(公告)日：1994-02-17

申请号：PCT/US1993006772

申请日：1993-07-22

Applicant: BIOMAGNETIC TECHNOLOGIES, INC.

Inventor： BIOMAGNETIC TECHNOLOGIES, INC. ,  WARDEN, Laurence ,  ESSER, Keith

IPC: F17C03/08

CPC classification number: B32B15/14 ,  B29C70/088 ,  B29C70/30 ,  B32B1/02 ,  B32B1/08 ,  B32B5/26 ,  B32B7/12 ,  B32B15/02 ,  B32B2307/304 ,  B32B2315/085 ,  B32B2439/00 ,  B32B2597/00 ,  F17C3/08 ,  F17C2203/032 ,  F17C2203/0345 ,  F17C2203/0391 ,  F17C2203/0629 ,  F17C2209/227 ,  F17C2270/0509

Abstract: A dewar (20) includes an inner dewar (22) and a dewar thermal shield (24). The dewar thermal shield (24) has a thermal shield body (32) formed of a layer of radiative insulation, an inner layer of fiberglass cloth (102) overlying the layer of radiative insulation (100), a metallic screen (104) overlying the inner layer (102), and an outer layer (106) of fiberglass cloth overlying the metallic screen (104). The dewar thermal shield (24) also has a thermal shield tail cap (34) attached to the thermal shield body (32). The tail cap (34) is formed of a layer of radiative insulation (50), a layer of fiberglass cloth (51) overlying the layer of radiative insulation (50), a layer of thermal foil (52) overlying the layer of fiberglass cloth (51), the thermal foil (52) being formed of thermal conductors embedded in a film adhesive matrix with the thermal conductors extending to the body (32), and a top layer of fiberglass cloth (54) overlying the layer of thermal foil (52).

Abstract translation: 杜瓦瓶（20）包括内部杜瓦瓶（22）和杜瓦瓶盖（24）。 杜瓦瓶热屏蔽（24）具有由辐射绝缘层形成的热屏蔽体（32），覆盖在辐射绝缘层（100）的层上的玻璃纤维布（102）的内层，覆盖 内层（102）和覆盖在金属屏（104）上的玻璃纤维布的外层（106）。 杜瓦瓶热屏蔽（24）还具有附接到热屏蔽体（32）的热屏蔽尾盖（34）。 尾盖（34）由辐射绝缘层（50），覆盖在辐射绝缘层（50）层上的玻璃纤维布（51）层，覆盖在玻璃纤维布层上的一层热箔（52）形成 （51）中，热箔（52）由热导体嵌入薄膜粘合剂基质中形成，热导体延伸到主体（32），并且顶层玻璃纤维布（54）覆盖在热箔层 52）。

公开(公告)号：WO1992012437A1

公开(公告)日：1992-07-23

申请号：PCT/US1991009195

申请日：1991-12-20

Applicant: BIOMAGNETIC TECHNOLOGIES, INC.

Inventor： BIOMAGNETIC TECHNOLOGIES, INC. ,  MARSDEN, James, R.

IPC: G01R33/035

CPC classification number: G01R33/0206 ,  G01R33/0354 ,  Y10S505/846

Abstract: A magnetometer (20) is prepared by depositing three thin-film SQUID magnetic field detectors (26, 28, 30) upon a substrate (24). Two of the detectors incorporate stripline SQUID detectors (26, 28) deposited at right angles to each other, to measure the orthogonal components of a magnetic field that lie in the plane of the substrate. The third detector uses a planar loop SQUID detector (30) that measures the component of the magnetic field that is perpendicular to the substrate. The stripline SQUID detectors have thin-film base (42) and counter (46) electrodes separated by an insulating layer (50) which is at least about 1 micrometer thick, and a pair of Josephson junctions (52) extending between the electrodes through the insulating layer.

公开(公告)号：WO1994028789A1

公开(公告)日：1994-12-22

申请号：PCT/US1994006750

申请日：1994-06-15

Applicant: BIOMAGNETIC TECHNOLOGIES, INC.

Inventor： BIOMAGNETIC TECHNOLOGIES, INC. ,  LYPCHUK, Tanya

IPC: A61B05/04

CPC classification number: A61B5/04005

Abstract: An apparatus and process for making biomagnetic measurements of a biological organism permits the internal sources of the activity to be identified. An array of dipole sources is identified by providing a plurality of biomagnetic sensors disposed at locations external to the biological organism, measuring a measured biomagnetic response at each of the sensors, and amplifiying and filtering the measured biomagnetic response. A solution of dipole sources within the biological organism is determined by forward calculating a computed biomagnetic response at each of the sensors resulting from the biomagnetic activity of a plurality of dipole sources, each of which dipole sources contributes a normalized total signal strength at the sensors, and solving for the strengths of each of the dipole sources by a minimum norm estimation procedure. Convergence on the solution is aided by iteratively removing from the determination those apparent sources that contribute only a small portion of the signal strength, and then resolving the resulting relationship.

Abstract translation: 用于制造生物体生物体的生物磁性测量的装置和方法允许识别活动的内部来源。 通过提供设置在生物体外部的位置处的多个生物磁传感器来测定偶极源的阵列，测量每个传感器处的测量的生物磁响应，以及放大和滤波所测量的生物磁响应。 通过在多个偶极子的生物磁性活动产生的每个传感器上计算出计算出的生物磁响应来确定偶极子在生物体内的解决方案，每个偶极子源均在传感器处贡献归一化的总信号强度， 并通过最小范数估计程序求解每个偶极子源的强度。 通过迭代地从决定中除去仅贡献信号强度的一小部分的表观来源，然后解决所得到的关系，帮助解决方案的收敛。

公开(公告)号：WO1994002864A1

公开(公告)日：1994-02-03

申请号：PCT/US1993006766

申请日：1993-07-21

Applicant: BIOMAGNETIC TECHNOLOGIES, INC.

Inventor： BIOMAGNETIC TECHNOLOGIES, INC. ,  WIKSWO, John, P., Jr. ,  BLACK, William, C., Jr. ,  HIRSCHKOFF, Eugene, C. ,  MARSDEN, James, R. ,  PAULSON, Douglas, N.

IPC: G01R33/035

CPC classification number: G01R33/0358 ,  Y10S505/846

Abstract: A magnetometer includes a support having two support surfaces that intersect each other along an intersection line that is perpendicular to a reference axis of the magnetometer. The support surfaces are preferably perpendicular to each other and are each inclined at an angle of 45 degrees to the reference axis. A planar sensor/detector array is mounted on each support surface. Each array includes at least two pairs of magnetic field sensors and associated SQUID detectors arranged such that the magnetic field sensors lie on a line that is parallel to the intersection line of the two support surfaces. The magnetometer can be used adjacent to a surface to measure components and spatial variation of the magnetic field near the surface, with the measured components resolved into the magnetic field vectors parallel to and perpendicular to the surface.

Abstract translation: 磁力计包括具有沿垂直于磁力计的参考轴的交叉线彼此相交的两个支撑表面的支撑件。 支撑表面优选地彼此垂直并且各自相对于参考轴线以45度的角度倾斜。 平面传感器/检测器阵列安装在每个支撑表面上。 每个阵列包括至少两对磁场传感器和相关联的SQUID检测器，其布置成使得磁场传感器位于平行于两个支撑表面的交线的线上。 磁力计可以与表面相邻使用，以测量表面附近的磁场的分量和空间变化，测量的分量被分解成平行于和垂直于表面的磁场矢量。