公开(公告)号：JP2009178167A

公开(公告)日：2009-08-13

申请号：JP2009117077

申请日：2009-05-13

Applicant: Fluidigm Corp ,  フルイディグム コーポレイション

Inventor： UNGER MARC A ,  MANGER IAN DAVID ,  MICHAEL RUSERO ,  YI YONG ,  MIYASHITA-LIN EMILY ,  WIENECKE ANJA ,  FACER GEOFFREY

IPC: C12M1/00 ,  G01N33/53 ,  B01F13/00 ,  B01L3/00 ,  C12N15/09 ,  C12Q1/25 ,  C12Q1/68 ,  C40B40/02 ,  C40B50/06 ,  C40B60/12 ,  C40B60/14 ,  F04B43/02 ,  G01N1/00 ,  G01N1/28 ,  G01N27/447 ,  G01N35/00 ,  G01N35/08 ,  G01N37/00

CPC classification number: C12M1/38 ,  B01F13/0059 ,  B01J2219/00337 ,  B01J2219/00353 ,  B01J2219/00403 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/0072 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50851 ,  B01L2300/0627 ,  B01L2300/123 ,  B01L2400/06 ,  C12Q1/68 ,  C12Q1/6844 ,  C40B60/14 ,  F16K11/20 ,  G01N35/00029 ,  G01N35/0098 ,  G01N2035/00366 ,  Y10T137/2076 ,  Y10T137/2496 ,  Y10T137/86292 ,  Y10T137/87249 ,  Y10T436/2575 ,  C12Q2565/501

Abstract: PROBLEM TO BE SOLVED: To provide a microfluidic device designed for the use in performing various chemical and biochemical analyses from the advantageous point of view achieved by using the microfluidic device and eliminating the present limitations of conventional devices. SOLUTION: This microfluidic device includes (a) a flow channel formed in an elastic material and (b) a plurality of blind flow channels, fluid-communicating with the flow channel, and the region of each of the blind flow channels is equipped with the blind flow channel specifying a reaction site. COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：提供设计用于从通过使用微流体装置实现的有利观点执行各种化学和生化分析的微流体装置，并消除传统装置的现有限制。 解决方案：该微流体装置包括（a）形成在弹性材料中的流动通道和（b）与流动通道流体连通的多个盲流通道，以及每个盲流通道的区域是 配备了指定反应部位的盲流通道。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：WO02060582A2

公开(公告)日：2002-08-08

申请号：PCT/US0145256

申请日：2001-11-16

Applicant: FLUIDIGM CORP ,  CHOU HOU-PU ,  MANGER IAN DAVID ,  UNGER MARC A ,  YI YONG ,  FERNANDEZ DAVE

Inventor： CHOU HOU-PU ,  MANGER IAN DAVID ,  UNGER MARC A ,  YI YONG ,  FERNANDEZ DAVE

IPC: B01L3/00 ,  B01L3/02 ,  B29C65/00 ,  B29C65/48 ,  B81B1/00 ,  F15C5/00 ,  F16K99/00 ,  G01N1/00 ,  B01L

CPC classification number: B01L3/02 ,  B01L3/0268 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0655 ,  B01L2400/0688 ,  B29C65/006 ,  B29C65/48 ,  B29C66/112 ,  B29C66/1122 ,  B29C66/114 ,  B29C66/1222 ,  B29C66/1224 ,  B29C66/1226 ,  B29C66/532 ,  B29C66/54 ,  B29C66/71 ,  B29L2031/756 ,  B81B2201/13 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0017 ,  F16K99/0048 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/008 ,  F16K2099/0084 ,  G01N1/14 ,  Y10T137/0318 ,  Y10T137/0396 ,  Y10T436/11 ,  Y10T436/118339 ,  Y10T436/119163 ,  B29K2021/00

Abstract: The present invention provides microfluidic devices, systems and methods for using the same, which facilitate the introduction of fluid to and from a microfluidic channel located within the microfluidic devices.

Abstract translation: 本发明提供了使用该流体装置的微流体装置，系统和方法，其有助于将流体引入到位于微流体装置内的微流体通道和从微流体通道中引入流体。

公开(公告)号：WO02060582A9

公开(公告)日：2003-05-30

申请号：PCT/US0145256

申请日：2001-11-16

Applicant: FLUIDIGM CORP ,  CHOU HOU-PU ,  MANGER IAN DAVID ,  UNGER MARC A ,  YI YONG ,  FERNANDEZ DAVE

Inventor： CHOU HOU-PU ,  MANGER IAN DAVID ,  UNGER MARC A ,  YI YONG ,  FERNANDEZ DAVE

IPC: B01L3/00 ,  B01L3/02 ,  B29C65/00 ,  B29C65/48 ,  B81B1/00 ,  F15C5/00 ,  F16K99/00 ,  G01N1/00

CPC classification number: B01L3/02 ,  B01L3/0268 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0655 ,  B01L2400/0688 ,  B29C65/006 ,  B29C65/48 ,  B29C66/112 ,  B29C66/1122 ,  B29C66/114 ,  B29C66/1222 ,  B29C66/1224 ,  B29C66/1226 ,  B29C66/532 ,  B29C66/54 ,  B29C66/71 ,  B29L2031/756 ,  B81B2201/13 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0017 ,  F16K99/0048 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/008 ,  F16K2099/0084 ,  G01N1/14 ,  Y10T137/0318 ,  Y10T137/0396 ,  Y10T436/11 ,  Y10T436/118339 ,  Y10T436/119163 ,  B29K2021/00

Abstract: The present invention provides microfluidic devices, systems and methods for using the same, which facilitate the introduction of fluid to and from a microfluidic channel located within the microfluidic devices.

Abstract translation: 本发明提供微流体装置，使用其的微流体装置，系统和方法，其有利于将流体引入微流体装置内的微流体通道以及从微流体通道中引出。

公开(公告)号：ES2403560T3

公开(公告)日：2013-05-20

申请号：ES02786834

申请日：2002-11-27

Applicant: FLUIDIGM CORP

Inventor： UNGER MARC A ,  MANGER IAN DAVID ,  LUCERO MICHAEL ,  YI YONG ,  MIYASHITA-LIN EMILY ,  WIENECKE ANJA ,  FACER GEOFFREY

IPC: B01L3/00 ,  B01F13/00 ,  G01N33/53 ,  C12M1/00 ,  C12Q1/25 ,  C12Q1/68 ,  C40B40/02 ,  C40B50/06 ,  C40B60/12 ,  C40B60/14 ,  F04B43/02 ,  G01N1/00 ,  G01N1/28 ,  G01N27/447 ,  G01N35/00 ,  G01N37/00

Abstract: Un dispositivo microfluídico (200), que comprende componentes elastoméricos, y que tiene un canal de flujo (204, 702), en el que dicho canal de flujo tiene una pluralidad de canales de flujo ciego (206) que se abren hacia el interior y están en comunicación de fluidos con el canal de flujo, caracterizándose cada canal de flujo ciego por tener una parte de apertura, una parte de canal, y una parte final, y en el que una región del final de cada canal de flujo ciego define un sitio de reacción (208, 706), en el que cada canal de flujo ciego está asociado con una válvula (212) que cuando se cierra aísla el sitio de reacción del canal de flujo, y caracterizado por que las válvulas asociadas con cada una de la pluralidad de canales de flujo ciego en comunicación de fluidos con el canal de flujo están bajo el control de un canal de control común (210, 712) y se cierran o abren de forma coordinada.

公开(公告)号：CA2467587A1

公开(公告)日：2003-06-12

申请号：CA2467587

申请日：2002-11-27

Applicant: FLUIDIGM CORP

Inventor： WIENECKE ANJA ,  YI YONG ,  FACER GEOFFREY ,  UNGER MARC A ,  LUCERO MICHAEL ,  MIYASHITA-LIN EMILY ,  MANGER IAN DAVID

IPC: G01N33/53 ,  B01F13/00 ,  B01L3/00 ,  C12M1/00 ,  C12Q1/25 ,  C12Q1/68 ,  C40B40/02 ,  C40B50/06 ,  C40B60/12 ,  C40B60/14 ,  F04B43/02 ,  G01N1/00 ,  G01N1/28 ,  G01N27/447 ,  G01N35/00 ,  G01N37/00 ,  C12M1/36 ,  G01N15/06 ,  C12N11/16 ,  C12P19/34

Abstract: A variety of elastomeric-based microfluidic devices and methods for using an d manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagent s have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and ge ne expression analyses.

公开(公告)号：EP1345698A4

公开(公告)日：2006-05-17

申请号：EP01997026

申请日：2001-11-16

Applicant: FLUIDIGM CORP

Inventor： CHOU HOU-PU ,  MANGER IAN DAVID ,  UNGER MARC A ,  YI YONG ,  FERNANDEZ DAVE

IPC: B01L3/00 ,  B01L3/02 ,  B29C65/00 ,  B29C65/48 ,  B81B1/00 ,  F15C5/00 ,  F16K99/00 ,  G01N1/00

CPC classification number: B01L3/02 ,  B01L3/0268 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0655 ,  B01L2400/0688 ,  B29C65/006 ,  B29C65/48 ,  B29C66/112 ,  B29C66/1122 ,  B29C66/114 ,  B29C66/1222 ,  B29C66/1224 ,  B29C66/1226 ,  B29C66/532 ,  B29C66/54 ,  B29C66/71 ,  B29L2031/756 ,  B81B2201/13 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0017 ,  F16K99/0048 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/008 ,  F16K2099/0084 ,  G01N1/14 ,  Y10T137/0318 ,  Y10T137/0396 ,  Y10T436/11 ,  Y10T436/118339 ,  Y10T436/119163 ,  B29K2021/00

Abstract: The present invention provides microfluidic devices, systems and methods for using the same, which facilitate the introduction of fluid to and from a microfluidic channel located within the microfluidic devices.

公开(公告)号：AU2002351187A1

公开(公告)日：2003-06-17

申请号：AU2002351187

申请日：2002-11-27

Applicant: FLUIDIGM CORP

Inventor： UNGER MARC A ,  MANGER IAN DAVID ,  LUCERO MICHAEL ,  YI YONG ,  MIYASHITA-LIN EMILY ,  WIENECKE ANJA ,  FACER GEOFFREY

IPC: G01N33/53 ,  B01F13/00 ,  B01L3/00 ,  C12M1/00 ,  C12Q1/25 ,  C12Q1/68 ,  C40B40/02 ,  C40B50/06 ,  C40B60/12 ,  C40B60/14 ,  F04B43/02 ,  G01N1/00 ,  G01N1/28 ,  G01N27/447 ,  G01N35/00 ,  G01N37/00 ,  C12M1/36 ,  C12N11/16 ,  G01N15/06 ,  C12P19/34

Abstract: A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyses.

公开(公告)号：AU2002248149A1

公开(公告)日：2002-08-12

申请号：AU2002248149

申请日：2001-11-16

Applicant: FLUIDIGM CORP

Inventor： UNGER MARC A ,  CHOU HOU-PU ,  FERNANDES DAVE ,  MANGER IAN DAVID ,  YI YONG

IPC: B01L3/00 ,  B01L3/02 ,  B29C65/00 ,  B29C65/48 ,  B81B1/00 ,  F15C5/00 ,  F16K99/00 ,  G01N1/00

Abstract: The present invention provides microfluidic devices, systems and methods for using the same, which facilitate the introduction of fluid to and from a microfluidic channel located within the microfluidic devices.

公开(公告)号：EP1463796A4

公开(公告)日：2006-03-08

申请号：EP02786834

申请日：2002-11-27

Applicant: FLUIDIGM CORP

Inventor： UNGER MARC A ,  MANGER IAN DAVID ,  LUCERO MICHAEL ,  YI YONG ,  MIYASHITA-LIN EMILY ,  WIENECKE ANJA ,  FACER GEOFFREY

IPC: G01N33/53 ,  B01F13/00 ,  B01L3/00 ,  C12M1/00 ,  C12Q1/25 ,  C12Q1/68 ,  C40B40/02 ,  C40B50/06 ,  C40B60/12 ,  C40B60/14 ,  F04B43/02 ,  G01N1/00 ,  G01N1/28 ,  G01N27/447 ,  G01N35/00 ,  G01N37/00 ,  C12M1/36 ,  C12N11/16 ,  C12P19/34 ,  G01N15/06

CPC classification number: C12M1/38 ,  B01F13/0059 ,  B01J2219/00337 ,  B01J2219/00353 ,  B01J2219/00403 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/0072 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50851 ,  B01L2300/0627 ,  B01L2300/123 ,  B01L2400/06 ,  C12Q1/68 ,  C12Q1/6844 ,  C40B60/14 ,  F16K11/20 ,  G01N35/00029 ,  G01N35/0098 ,  G01N2035/00366 ,  Y10T137/2076 ,  Y10T137/2496 ,  Y10T137/86292 ,  Y10T137/87249 ,  Y10T436/2575 ,  C12Q2565/501

Abstract: A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyses.

Abstract translation: 提供了各种基于弹性体的微流体装置和用于使用和制造这种装置的方法。 某些设备具有反应位置阵列以便于高通量分析。 一些装置还包括位于盲制通道末端的反应位置，在制造过程中试剂已经被预先沉积。 一旦将样品引入反应部位，试剂就会停止。 这些装置可以与各种加热装置一起使用，因此可用于需要温度控制的各种分析，包括热循环应用，如核酸扩增反应，基因分型和基因表达分析。

公开(公告)号：EP1336097A4

公开(公告)日：2006-02-01

申请号：EP01979990

申请日：2001-10-12

Applicant: FLUIDIGM CORP

Inventor： MANGER IAN DAVID ,  HAO CUNSHENG CASEY ,  UNGER MARC ALEXANDER

IPC: B01L3/00 ,  A61L15/38 ,  A61L15/40 ,  B01L3/02 ,  B81B1/00 ,  B81C1/00 ,  G01N30/72 ,  H01J49/04

CPC classification number: G01N1/10 ,  B01L3/0241 ,  B01L3/5027 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/027 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0481 ,  G01N30/7266 ,  H01J49/0018 ,  H01J49/165 ,  Y10T436/117497 ,  Y10T436/24 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: This invention provides a microfluidic sample injection apparatus (14, 100) for injecting a fluid sample into an analytical device (120) and a method for using the same. The microfluidic sample injection apparatus (14, 100) comprises a microfluidic device (100) and an integrated sample injection capillary (14) which is in fluid communication with a fluid flow channel of the microfluidic device (100).

Abstract translation: 本发明提供微流体装置及其使用方法。 本发明的微流体装置包括第一弹性层，弹性层内的流体流动通道; 以及用于将流体样品从流体流动通道提供到分析装置的装置。 本发明还提供了一种包括这种微流体装置和分析装置的分析装置。