公开(公告)号：AU1231492A

公开(公告)日：1992-08-27

申请号：AU1231492

申请日：1992-01-24

Applicant: GLAXO INC

Inventor： LUZZIO MICHAEL J ,  BESTERMAN JEFFREY M ,  EVANS MICHAEL G ,  ROSS JOHNSON M

IPC: C07D491/04 ,  C07D491/056 ,  A61K31/47

Abstract: The present invention relates to the compounds of formula (I), wherein: R is hydrogen, hydroxy or amino; R is hydrogen, hydroxy, methoxy or methoxymethoxy; R is hydrogen, hydroxy, amino, methoxy, methoxymethoxy or, taken together with R , methylenedioxy (also known as 1,3 dioxolo); R is hydrogen, hydroxy, methoxy, methoxymethoxy, benzyl, di(C1-4)alkylaminomethyl or, taken together with R , methylenedioxy; R is hydrogen or hydroxy; provided that at least one of R through R is other than hydrogen; and i) X is hydroxy or methoxy with X , X and X being hydrogen; or ii) X taken together with X , X taken together with X or X taken together with X , is methylenedioxy, provided that each of the remaining respective X , X , X and X substituents are hydrogen, intermediates in the synthesis of them, pharmaceutical formulation containing them, their use as inhibitors of topoisomerase and their use in the treatment of tumors.