公开(公告)号：EP1027055B1

公开(公告)日：2004-01-07

申请号：EP98955131.2

申请日：1998-10-27

Applicant: HOWARD UNIVERSITY

Inventor： SCOTT, Kenneth, R. ,  LAWS, Mia, L. ,  ROBERTS, Ralph, R. ,  NICHOLSON, Jesse, M.

IPC: A61K31/5415 ,  A61P25/08 ,  A61P25/12

CPC classification number: C07D279/20

Abstract: Phenothiazines of formula (I) where R1 is H or -COOR, where R is selected from the group consisting of branched or unbranched alkyl groups containing from 1 to 4 carbon atoms, and where X is selected from H, branched or unbranched alkyl groups containing from 1 to 4 carbons, and halogen, and pharmaceutically acceptable salts thereof. Particularly preferred phenothiazines are those wherein X is hydrogen, chloro, bromo or methyl, R1 is COOR, and R is methyl, ethyl or t-butyl.

公开(公告)号：EP1027055A1

公开(公告)日：2000-08-16

申请号：EP98955131.2

申请日：1998-10-27

Applicant: HOWARD UNIVERSITY

Inventor： SCOTT, Kenneth, R. ,  LAWS, Mia, L. ,  ROBERTS, Ralph, R. ,  NICHOLSON, Jesse, M.

IPC: A61K31/54 ,  C07D279/20

CPC classification number: C07D279/20

Abstract: Phenothiazines of formula (I) where R1 is H or -COOR, where R is selected from the group consisting of branched or unbranched alkyl groups containing from 1 to 4 carbon atoms, and where X is selected from H, branched or unbranched alkyl groups containing from 1 to 4 carbons, and halogen, and pharmaceutically acceptable salts thereof. Particularly preferred phenothiazines are those wherein X is hydrogen, chloro, bromo or methyl, R1 is COOR, and R is methyl, ethyl or t-butyl.

公开(公告)号：WO1993017678A1

公开(公告)日：1993-09-16

申请号：PCT/US1993001924

申请日：1993-03-02

Applicant: HOWARD UNIVERSITY

Inventor： HOWARD UNIVERSITY ,  SCOTT, Kenneth, R. ,  NICHOLSON, Jesse, M. ,  EDAFIOGHO, Ivan, O.

IPC: A61K31/24

CPC classification number: C07D295/30 ,  C07C45/512 ,  C07C225/20 ,  C07C229/48 ,  C07C237/24 ,  C07C243/22 ,  C07C2601/16 ,  C07C49/403

Abstract: Enaminones which display anticonvulsant activity having formula (I) wherein R is from the group consisting of COOCH3 and COOC2H5; R is from the group consisting of H and CH3; R is from the group consisting of H and CH3; and R is from the group consisting of heterocyclic radicals, substituted heterocyclic radicals, benzyls, substitued benzyls, disubstituted benzyls, hydrazinos, substituted hydrazinos, disubstituted hydrazinos, disubstituted phenyls and trisubstituted phenyls, wherein the substituted species are second radicals having positive lipophilicity.

Abstract translation: 显示具有式（I）的抗惊厥活性的呼吸虫，其中R是由COOCH 3和COOC 2 H 5组成的组; R 1来自H和CH 3; R 2来自H和CH 3; R 3为杂环基，取代的杂环基，苄基，取代的苄基，二取代的苄基，肼基，取代的肼基，二取代的肼基，二取代的苯基和三取代的苯基，其中取代的物质是具有正性亲油性的第二基团 。