公开(公告)号：US09645141B2

公开(公告)日：2017-05-09

申请号：US14093305

申请日：2013-11-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kwan Hyi Lee ,  Ho Young Park ,  Yu Chan Kim ,  Hyun Kwang Seok ,  Seok Lee

IPC: G01N33/543

CPC classification number: G01N33/54326

Abstract: A method for diagnosing a biomarker using magnetic particles and quantum dots for quantitative analysis and a biomarker diagnosis kit are provided. The method for diagnosing a biomarker includes: ii) providing magnetic particles having surfaces to which a primary antibody capable of collecting a biomarker using a linker is fixed; ii) providing quantum dots having surfaces to which a secondary antibody capable of detecting the biomarker is fixed; iii) sandwich-targeting the biomarker by the magnetic particles and the quantum dots; iv) selectively separating quantum dots sandwich-targeting the biomarker among the quantum dots; and v) quantifying the concentration of the biomarker by measuring absorbance or intensity of fluorescence of separated quantum dots.

公开(公告)号：US10739301B2

公开(公告)日：2020-08-11

申请号：US15684939

申请日：2017-08-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kwan Hyi Lee ,  Minhong Jeun ,  Seok Lee ,  Sang Kyung Kim ,  Sungwook Park

IPC: H01L29/45 ,  G01N27/414

Abstract: Provided is a field-effect transistor that can reduce noise, be produced by a simplified manufacturing method, and also have a plurality of active patterns and gate patterns designed to be combinable according to a detection purpose. The field-effect transistor includes a lower silicon layer and a buried oxide layer disposed on the lower silicon layer; an active pattern disposed on the buried oxide layer and including a channel region, a source region, and a drain region; a gate pattern disposed on the active pattern to at least partially overlap the active pattern; a source electrode disposed in direct contact with the source region on the active pattern, and a drain electrode disposed in direct contact with the drain region on the active pattern; and a gate insulating film disposed between the active pattern and the gate pattern.

公开(公告)号：US12049564B2

公开(公告)日：2024-07-30

申请号：US16855547

申请日：2020-04-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Youngdo Jeong ,  Kwan Hyi Lee ,  Hyojin Lee

IPC: C08L79/04 ,  A61K9/51 ,  C08G73/06 ,  C08K3/105 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

CPC classification number: C08L79/04 ,  A61K9/5146 ,  C08G73/06 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00 ,  C08K3/105

Abstract: Provided are positively charged nanoparticles and use thereof. According to the nanoparticles of an aspect, cucurbituril may limit electrostatic attraction between a guest for cucurbituril and a metal salt, thereby generating nanoparticles with a uniform size. Accordingly, the nanoparticles may have an effect of being capable of efficient intracellular gene delivery.