公开(公告)号：CA2613875C

公开(公告)日：2018-09-25

申请号：CA2613875

申请日：2006-06-29

Applicant: KRISHNAN RAMU

Inventor： KRISHNAN RAMU

IPC: A61K31/56 ,  C07J5/00

Abstract: The administration of pharmaceuticals of drugs which are having less solubility, lower bioavailability, lower bioabsorbability, less rte of absorption has become a big challenge in day today life. Therefore anattempt has been made to prepare a complex modified form of the said pharmaceutical or drug such that the modified complex drugs or pharmaceuticals exhibits the enhanced properties of solubility, bioavailability, bioabsorbability and rate of absorption despite the increased complexity of the molecule. Surprisingly such modification was found to enhance retentivity of the active drug ingredient in the blood. Higher amounts of the active drug ingredient has shown lower toxicity.

公开(公告)号：EP1898922A4

公开(公告)日：2012-03-14

申请号：EP06766275

申请日：2006-06-29

Applicant: KRISHNAN RAMU

Inventor： KRISHNAN RAMU

IPC: A61K31/56 ,  A61K9/00 ,  A61K31/397 ,  A61K31/40 ,  A61K31/47 ,  A61K31/505 ,  A61P3/06 ,  C07J5/00

CPC classification number: A61K31/426 ,  A61K9/0014 ,  A61K9/0053 ,  A61K47/186

公开(公告)号：AU2006264407B2

公开(公告)日：2012-08-30

申请号：AU2006264407

申请日：2006-06-29

Applicant: KRISHNAN RAMU

Inventor： KRISHNAN RAMU

IPC: A61K31/56 ,  C07J5/00

Abstract: The administration of pharmaceuticals of drugs which are having less solubility, lower bioavailability, lower bioabsorbability, less rte of absorption has become a big challenge in day today life. Therefore anattempt has been made to prepare a complex modified form of the said pharmaceutical or drug such that the modified complex drugs or pharmaceuticals exhibits the enhanced properties of solubility, bioavailability, bioabsorbability and rate of absorption despite the increased complexity of the molecule. Surprisingly such modification was found to enhance retentivity of the active drug ingredient in the blood. Higher amounts of the active drug ingredient has shown lower toxicity.

公开(公告)号：CA2613875A1

公开(公告)日：2007-01-11

申请号：CA2613875

申请日：2006-06-29

Applicant: KRISHNAN RAMU

Inventor： KRISHNAN RAMU

IPC: A61K31/56 ,  C07J5/00

Abstract: The administration of pharmaceuticals of drugs which are having less solubility, lower bioavailability, lower bioabsorbability, less rate of absorption has become a big challenge in day to day life. Therefore an attempt has been made to prepare a complex modified form of the said pharmaceutical or drug such that the modified complex drugs or pharmaceuticals exhibits the enhanced properties of solubility, bioavailability, bioabsorbability and rate of absorption despite the increased complexity of the molecule. Surprisingly such modification was found to enhance retentivity of the active drug ingredient in the blood. Higher amounts of the active drug ingredient has shown lower toxicity.

公开(公告)号：AU2006264407A1

公开(公告)日：2007-01-11

申请号：AU2006264407

申请日：2006-06-29

Applicant: KRISHNAN RAMU

Inventor： KRISHNAN RAMU

IPC: A61K31/56 ,  C07J5/00

Abstract: The administration of pharmaceuticals of drugs which are having less solubility, lower bioavailability, lower bioabsorbability, less rate of absorption has become a big challenge in day to day life. Therefore an attempt has been made to prepare a complex modified form of the said pharmaceutical or drug such that the modified complex drugs or pharmaceuticals exhibits the enhanced properties of solubility, bioavailability, bioabsorbability and rate of absorption despite the increased complexity of the molecule. Surprisingly such modification was found to enhance retentivity of the active drug ingredient in the blood. Higher amounts of the active drug ingredient has shown lower toxicity.

公开(公告)号：WO2004082592A3

公开(公告)日：2004-12-16

申请号：PCT/IN2004000063

申请日：2004-03-17

Applicant: KRISHNAN RAMU

Inventor： KRISHNAN RAMU

IPC: A23L1/30 ,  A61K20060101 ,  C07C229/76

CPC classification number: C07C229/76 ,  A23L33/17

Abstract: The present invention relates to compositions and methods for preparing Metal Amino Acid Chelates having a nutritionally relevant Anion Radical(s) having higher solubility and better bio absorption. The composition is prepared by reacting a metal Amino Acid Hydroxide Chelate with a nutritionally relevant acid radical in a suitable mole ratio such that the new chelate formed has the metal Amino Acid Structure unchanged but is bonded forming quarternary ammonium ion(s) to a nutritionally Relevant Anion Radical(s) obtained by ionic dissociation of a nutritionally Relevant acid(s).

Abstract translation: 本发明涉及用于制备具有较高溶解度和较好生物吸收的营养相关阴离子自由基的金属氨基酸螯合物的组合物和方法。 该组合物通过使金属氨基酸氢氧化物螯合物与营养相关酸基以合适的摩尔比反应来制备，使得所形成的新螯合物具有未改变的金属氨基酸结构但键合形成季铵离子到营养相关物 通过离子解离营养相关酸获得的阴离子自由基。

公开(公告)号：WO2007004236A2

公开(公告)日：2007-01-11

申请号：PCT/IN2006000222

申请日：2006-06-29

Applicant: KRISHNAN RAMU

Inventor： KRISHNAN RAMU

IPC: A61K31/426

CPC classification number: A61K31/426 ,  A61K9/0014 ,  A61K9/0053 ,  A61K47/186

Abstract: The administration of pharmaceuticals of drugs which are having less solubility, lower bioavailability, lower bioabsorbability, less rte of absorption has become a big challenge in day today life. Therefore anattempt has been made to prepare a complex modified form of the said pharmaceutical or drug such that the modified complex drugs or pharmaceuticals exhibits the enhanced properties of solubility, bioavailability, bioabsorbability and rate of absorption despite the increased complexity of the molecule. Surprisingly such modification was found to enhance retentivity of the active drug ingredient in the blood. Higher amounts of the active drug ingredient has shown lower toxicity.

Abstract translation: 溶解度较低，生物利用度较低，生物可吸收性较低，吸收较少的药物给药已成为今日生活中的一大挑战。 因此，已经做出了制备所述药物或药物的复杂修饰形式的解释，使得尽管分子复杂性增加，但修饰的复合药物或药物表现出增强的溶解度，生物利用度，生物可吸收性和吸收速率性质。 令人惊讶的是，发现这种修饰增强了血液中活性药物成分的保留性。 较高量的活性药物成分显示较低的毒性。