公开(公告)号：US20160187283A1

公开(公告)日：2016-06-30

申请号：US14892666

申请日：2014-06-06

Applicant: LIFESCAN SCOTLAND LIMITED

Inventor： Alexander COOPER ,  James Iain RODGERS ,  Gavin MACFIE

IPC: G01N27/327 ,  C12Q1/00

CPC classification number: G01N27/3272 ,  C12Q1/001 ,  C12Q1/004

Abstract: Electrochemical-based analytical test strip with a soluble electrochemically-active coating opposite a bare electrode An electrochemical-based analytical test strip (EBATS) for the determination of an analyte in a bodily fluid sample includes an electrically insulating base layer, a patterned electrically conductive layer disposed on the electrically insulating base layer and including a plurality of electrodes, and an enzymatic reagent layer disposed on a portion of the patterned conductor layer and defining a bare electrode(s) and a plurality of enzymatic reagent covered electrodes from the plurality of electrodes. The EBATS also includes a patterned spacer layer, a top layer having an underside surface (USS), and a soluble electrochemically-active coating (SEAC) disposed on the USS of the top layer. In addition, at least the patterned spacer layer and top layer define a sample-receiving chamber within the EBATS. Furthermore, the SEAC is disposed on the USS of the top layer within at least a portion the sample-receiving chamber and in an opposing relationship to the bare electrodes.

Abstract translation: 具有与裸露电极相对的可溶电化学活性涂层的基于电化学的分析测试条用于测定体液样品中的分析物的基于电化学的分析测试条（EBATS）包括电绝缘基底层，图案化导电层 设置在所述电绝缘基底层上并且包括多个电极，以及设置在所述图案化导体层的一部分上并且从所述多个电极限定裸电极和多个酶试剂覆盖电极的酶试剂层。 EBATS还包括图案化间隔层，具有下表面（USS）的顶层和设置在顶层的USS上的可溶电化学活性涂层（SEAC）。 此外，至少图案化间隔层和顶层限定EBATS内的样品接收室。 此外，SEAC设置在至少部分样品接收室内的顶层的USS上，并且与裸露电极相对的关系。

公开(公告)号：US20150362453A1

公开(公告)日：2015-12-17

申请号：US14764427

申请日：2014-01-30

Applicant: LIFESCAN SCOTLAND LIMITED

Inventor： Gavin MACFIE ,  Alexander COOPER ,  Christopher LEACH ,  Stephen MACKINTOSH

IPC: G01N27/327

CPC classification number: G01N27/3272 ,  C12Q1/001 ,  G01N27/3271

Abstract: An electrochemical-based analytical test strip (EBATS) for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) includes an electrically insulating base layer (110), a patterned electrically conductive layer (120) disposed on the electrically insulating base layer, an enzymatic reagent layer (140) disposed on the patterned electrically conductor layer, a patterned spacer layer (150), a top layer (170) having an underside surface, and a soluble acidic material coating (160) on the underside surface of the top layer. The patterned spacer layer and top layer define a sample-receiving chamber (180) within the EBATS and the soluble acidic material coating is disposed on the underside surface of the top layer within the sample-receiving chamber. In addition, the soluble acidic material coating is operably dissolvable in the bodily fluid sample such that a pH of the bodily fluid sample in the sample-receiving chamber is reduced during use of the EBATS.

Abstract translation: 用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）的基于电化学的分析测试条（EBATS）包括电绝缘基底层（110），图案化导电层 （120），设置在图案化导电体层上的酶试剂层（140），图案化间隔层（150），具有下表面的顶层（170）和可溶性酸性物质 在顶层的下表面上涂覆（160）。 图案化间隔层和顶层限定EBATS内的样品接收室（180），并且可溶性酸性材料涂层设置在样品接收室内的顶层的下表面上。 此外，可溶性酸性材料涂层可操作地溶解在体液样品中，使得在使用EBATS期间样品接收室中的体液样品的pH降低。

公开(公告)号：US20150369769A1

公开(公告)日：2015-12-24

申请号：US14313377

申请日：2014-06-24

Applicant: LifeScan Scotland Limited

Inventor： Alexander COOPER ,  Antony SMITH ,  Lynsey WHYTE ,  Neil WHITEHEAD ,  David MCCOLL ,  Brian GUTHRIE ,  Timothy LLOYD ,  Rossano MASSARI ,  Christian FORLANI

IPC: G01N27/327

CPC classification number: G01N27/327 ,  B01L2300/0645 ,  G01N27/3272 ,  G01N31/164 ,  G01N33/0031 ,  G01N2030/645

Abstract: An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) and/or a characteristic of the bodily fluid sample (e.g., hematocrit) includes a sample-entry chamber with a sample-application opening disposed on an end edge of the electrochemical-based analytical test strip, and first and second sample-determination chambers, each in direct fluidic communication with the sample-entry chamber. The electrochemical-based analytical test strip also includes first and second electrodes (such as first and second hematocrit electrodes) disposed in the first sample-determination chamber, and a third and fourth electrodes (for example working and reference electrodes) disposed in the second sample-determination chamber. Moreover, the first and second sample-determination chambers intersect the sample-entry chamber perpendicular (or nearly perpendicular) to one another and the first sample-determination chamber also intersects the sample-entry chamber in an aligned manner.

Abstract translation: 用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）和/或体液样品的特征（例如，血细胞比容）的基于电化学的分析测试条包括样品 具有设置在基于电化学的分析测试条的端部边缘上的样品施加开口的第一和第二样品室，以及与样品入口室直接流体连通的第一和第二样品测定室。 基于电化学的分析测试条还包括设置在第一样品测定室中的第一和第二电极（例如第一和第二血细胞比容电极）和设置在第二样品中的第三和第四电极（例如工作和参考电极） 测定室。 此外，第一和第二样品确定室将样品入口室彼此垂直（或几乎垂直）相交，并且第一样品测定室也以对准的方式与样品入口室相交。