公开(公告)号：DE112017005511T5

公开(公告)日：2019-09-12

申请号：DE112017005511

申请日：2017-09-13

Applicant: OLYMPUS CORP

Inventor： KUBO KEI

IPC: A61B1/00 ,  A61B1/045

Abstract: Ein Prozessor 13 umfasst: einen Bereichs-Extraktions-Abschnitt 45, der dazu eingerichtet ist, eine Eingabe eines ersten Bildsignals zu empfangen, das als Ergebnis des Erzeugens eines Bildes eines Objektes erhalten wird, das mit erstem Schmalbandlicht beleuchtet wird, das eine Wellenlänge umfasst, die von Blut in einem grünen Wellenlängenband minimal absorbiert wird, wobei das Bild des Objektes eine Blutungsstelle enthält, und einen Bloodpool-Bereich zu extrahieren, der eine Blutkonzentration aufweist, die kleiner ist als eine Blutkonzentration der Blutungsstelle in einem Bereich, der das Blut im ersten Bildsignal darstellt; und einen Helligkeitswert-Erhöhungs-Abschnitt 46, der dazu eingerichtet ist, einen Helligkeitswert des Bloodpool-Bereichs in entweder dem ersten Bildsignal oder dem zweiten Bildsignal zu erhöhen, das als Ergebnis des Erzeugens eines Bildes des Objektes erhalten wird, das mit zweitem Schmalbandlicht beleuchtet wird, dessen Wellenlänge kürzer ist und das von dem Blut mehr absorbiert wird als das erste Schmalbandlicht.

公开(公告)号：DE112017002547T5

公开(公告)日：2019-02-21

申请号：DE112017002547

申请日：2017-03-01

Applicant: OLYMPUS CORP

Inventor： KUBO KEI

IPC: A61B1/00 ,  A61B1/045

Abstract: Ein Lebendkörper-Beobachtungssystem umfasst eine Lichtquelleneinheit, die ausgestaltet ist, in der Lage zu sein, Licht in einem ersten Wellenlängenband als Schmalbandlicht zu emittieren, das zu einem Rotbereich in einem sichtbaren Bereich gehört, Licht in einem zweiten Wellenlängenband als Schmalbandlicht zu emittieren, das zu einer Seite längerer Wellenlänge gehört als das erste Wellenlängenband, und Licht in einem dritten Wellenlängenband als Licht zu emittieren, das zu einer Seite kürzerer Wellenlänge gehört als das erste Wellenlängenband, eine Steuereinheit, die ausgestaltet ist, eine Steuerung auszuführen, um Beleuchtungslicht, umfassend das Licht jeweils in dem ersten bis dritten Wellenlängenband, zu emittieren, eine erste Bildaufnahmeeinrichtung, die ausgestaltet ist, eine Empfindlichkeit in jedem, dem ersten und dem dritten Wellenlängenband, aufzuweisen, eine zweite Bildaufnahmeeinrichtung, die ausgestaltet ist, eine Empfindlichkeit in dem zweiten Wellenlängenband

公开(公告)号：EP2926713A4

公开(公告)日：2016-07-20

申请号：EP13859294

申请日：2013-11-22

Applicant: OLYMPUS CORP

Inventor： KUBO KEI ,  ISHIHARA YASUSHIGE ,  SHIDA HIROMI

IPC: A61B1/00 ,  A61B1/04 ,  A61B1/06 ,  G01N21/64 ,  G02B23/24 ,  G02B23/26 ,  H04N5/225

CPC classification number: A61B1/0638 ,  A61B1/00009 ,  A61B1/00186 ,  A61B1/043 ,  G02B23/2484 ,  G02B23/26 ,  H04N2005/2255

Abstract: Provided is an observation apparatus (100) comprising a light source (3) that irradiates a subject (X) with illumination light and special light that acts on a specific region of the subject (X); a return-light-image generating portion (61) that generates a return-light image (G1) by capturing return light coming from the subject (X) due to irradiation with the illumination light; a special-light-image generating portion (62) that generates a special-light image (G2) by capturing signal light coming from the subject (X) due to irradiation with the special light; an extraction portion (63) that extracts the specific region from the special-light image (G2); and an enhancement processing portion (64) that performs enhancement processing, which is based on return-light image information, on the return-light image (G1), in a region corresponding to the extracted specific region.

公开(公告)号：EP3037030A4

公开(公告)日：2017-04-19

申请号：EP14838502

申请日：2014-07-14

Applicant: OLYMPUS CORP

Inventor： KUBO KEI ,  ISHIHARA YASUSHIGE

IPC: A61B1/00 ,  A61B1/04 ,  A61B1/045 ,  A61B1/06

CPC classification number: A61B5/0071 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/043 ,  A61B1/045 ,  A61B1/0638 ,  A61B1/0646 ,  G06T5/008 ,  G06T5/50 ,  G06T19/006 ,  G06T19/20 ,  G06T2207/10064 ,  G06T2207/10068 ,  G06T2207/20212

Abstract: Provided is a fluorescence observation apparatus (100) including a light source (3) that radiates illumination light and excitation light onto a subject; a return-light-image generating portion (61) and a fluorescence-image generating portion (62) that generate a return-light image (G1) and a fluorescence image (G2) of the subject, respectively; a fluorescence detecting portion (63) that detects a fluorescence region in the fluorescence image (G2); a return-light-image adjusting portion (65) that adjusts gradation values of the return-light image (G1); a superimposed-image generating portion (66) that generates a superimposed image (G3) by using the return-light image (G1'), in which the gradation values have been adjusted, and the fluorescence image (G2); and a coefficient setting portion (64) that sets, in the case in which the fluorescence region is detected by the fluorescence detecting portion (63), a degree-of-adjustment, by which the gradation values of the return-light image (G1) are adjusted by the return-light-image adjusting portion (65), so that the gradation values of the return-light image (G1) are decreased as compared with the case in which the fluorescence region is not detected by the fluorescence detecting portion (63).

公开(公告)号：EP2596739A4

公开(公告)日：2017-08-16

申请号：EP11849714

申请日：2011-11-08

Applicant: OLYMPUS CORP

Inventor： KUBO KEI ,  DOGUCHI NOBUYUKI

IPC: A61B1/00 ,  A61B1/06

CPC classification number: A61B1/043 ,  A61B1/00006 ,  A61B1/041 ,  A61B1/0661

Abstract: A medical apparatus of the present invention comprises: a storing section in which information concerning a drug kinetics in a living body is stored in advance for each of plural kinds of fluorescent drugs; an arithmetic processing section that acquires diagnosis start time corresponding to a desired fluorescent drug based on information stored in the storing section, information concerning a target region of an object to be examined to which the desired fluorescent drug is administered, information concerning a method of administering the desired fluorescent drug to the target region, and information concerning administration start time of the desired fluorescent drug; and a light source control section that performs control to stop radiation of excitation light for exciting the desired fluorescent drug in at least a time period from the administration start time until the diagnosis start time is reached and performs control to radiate the excitation light based on the diagnosis start time.

Abstract translation: 本发明的医疗设备包括：存储部分，其中预先存储关于多种荧光药物中的每一种的关于活体中的药物动力学的信息; 算术处理部分，其基于存储在存储部分中的信息获取与期望的荧光药物相对应的诊断开始时间;关于被施用了期望的荧光药物的待检查对象的目标区域的信息;关于施用方法的信息 所需的荧光药物到目标区域，以及关于所需荧光药物的给药开始时间的信息; 以及光源控制部，其在从管理开始时刻起至到达诊断开始时刻为止的期间内，至少停止激励期望的荧光药剂的激发光的照射，并进行控制以基于 诊断开始时间。

公开(公告)号：EP2835092A4

公开(公告)日：2015-12-09

申请号：EP13772945

申请日：2013-03-28

Applicant: OLYMPUS CORP

Inventor： KUBO KEI ,  ISHIHARA YASUSHIGE ,  SHIDA HIROMI ,  TAKEKOSHI SATOSHI

IPC: A61B1/00 ,  A61B1/04

CPC classification number: G01N21/6456 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/00055 ,  A61B1/043 ,  A61B1/045 ,  F04C2270/041 ,  G01N2201/124 ,  G06K9/4604 ,  G06T7/0012 ,  G06T2207/30004

公开(公告)号：JP2013212323A

公开(公告)日：2013-10-17

申请号：JP2012085258

申请日：2012-04-04

Applicant: Olympus Corp ,  オリンパス株式会社 ,  Olympus Medical Systems Corp ,  オリンパスメディカルシステムズ株式会社

Inventor： KUBO KEI ,  ISHIHARA YASUNARI ,  SHIDA YUMI ,  TAKEKOSHI SATOSHI

IPC: A61B1/00 ,  A61B1/04

CPC classification number: G01N21/6456 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/00055 ,  A61B1/043 ,  A61B1/045 ,  F04C2270/041 ,  G01N2201/124 ,  G06K9/4604 ,  G06T7/0012 ,  G06T2207/30004

Abstract: PROBLEM TO BE SOLVED: To allow an operator to reliably and clearly recognize the presence of a lesion part within an observation visual field.SOLUTION: A fluorescence observation device 1 is provided with: an imaging element 19 for acquiring a fluorescence image by imaging fluorescence generated in a subject A by being irradiated with excitation light from an excitation light source 3; a sensitivity adjustment part 23 for setting sensitivity of the imaging element 19 to the fluorescence on the basis of a gradation value of the fluorescence image acquired by the imaging element 19; an extraction part 25 for extracting an area that has a larger gradation value than a prescribed threshold value from the fluorescence image acquired by the imaging element 19 by the sensitivity set by the sensitivity adjustment part 23; a notification part 25 for presenting information indicating the presence of an area extracted by the extraction part 25 to an operator; a display part 7 for displaying the fluorescence image; and a display switching part 24 for causing the display part 7 to display the fluorescence image when the sensitivity set by the sensitivity adjustment part 23 to the imaging element 19 is the predetermined threshold value or lower, and causing the notification part 25 to present information when the sensitivity is greater than the predetermined threshold value.

Abstract translation: 要解决的问题：允许操作者可靠且清楚地识别观察视野内的病变部位的存在。解决方案：荧光观察装置1设置有：成像元件19，用于通过成像荧光获得荧光图像 通过用激发光源3的激发光照射被检体A; 灵敏度调节部23，用于根据由摄像元件19获取的荧光图像的灰度值来设定摄像元件19对荧光的灵敏度; 提取部分25，用于通过由灵敏度调节部分23设定的灵敏度从由成像元件19获取的荧光图像中提取具有比规定阈值更大的灰度值的区域; 通知部分25，用于向操作员呈现指示由提取部分25提取的区域的存在的信息; 用于显示荧光图像的显示部分7; 以及显示切换部24，用于当由灵敏度调节部23对摄像元件19设定的灵敏度为规定的阈值以下时，使显示部7显示荧光图像，并使通知部25呈现信息， 灵敏度大于预定阈值。

公开(公告)号：JP2014030488A

公开(公告)日：2014-02-20

申请号：JP2012171181

申请日：2012-08-01

Applicant: Olympus Corp ,  オリンパス株式会社 ,  Olympus Medical Systems Corp ,  オリンパスメディカルシステムズ株式会社

Inventor： SHIDA YUMI ,  ISHIHARA YASUNARI ,  TAKEKOSHI SATOSHI ,  KUBO KEI

IPC: A61B1/00 ,  A61B1/04

CPC classification number: A61B5/0033 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/00055 ,  A61B1/043 ,  G06T5/50 ,  G06T7/0014 ,  G06T2207/10121 ,  G06T2207/30088

Abstract: PROBLEM TO BE SOLVED: To enable reliably notifying a user of the presence of a fluorescent area in an observation visual field irrespective to differences of observation conditions.SOLUTION: A fluorescent observation device 1 comprises: a light source 3 for irradiating an observation object X with reference light and excitation light; a fluorescent image generation part 62 for generating a fluorescent image G2 by imaging fluorescence generated in the observation object X by irradiation of the excitation light; a reference image generation part 61 for generating a reference image G1 by imaging return light that is returned from the observation object X by irradiation of the reference light; an image composition part 65 for generating a composite image G by superposing the fluorescent image G2 generated by the fluorescent image generation part 62 on the reference image G1 generated by the reference image generation part 61; a determination part 63 for comparing a luminance value in each position in the reference image G1 to a predetermined threshold and determining the presence and absence of a position in which a luminance value is equal to or less than the threshold; and a notification part 65 that notifies, when a position with a luminance value equal to or less than the predetermined threshold is determined as being present by the determination part 63, a user of the presence of the position.

Abstract translation: 要解决的问题：能够在观察视野中可靠地通知用户荧光区域的存在，而与观察条件的差异无关。解决方案：荧光观察装置1包括：用于将观察对象X照射到 参考光和激发光; 荧光图像生成部62，用于通过激发光的照射对观察对象X中产生的荧光进行成像而生成荧光图像G2; 参考图像生成部61，用于通过对参考光的照射从观察对象X返回的返回光成像来生成参考图像G1; 图像合成部65，用于通过将由荧光图像生成部62生成的荧光图像G2叠加在基准图像生成部61生成的参照图像G1上来生成合成图像G; 确定部63，用于将参考图像G1中的每个位置的亮度值与预定阈值进行比较，并确定亮度值等于或小于阈值的位置的存在与否; 以及通知部65，当确定部63确定具有等于或小于预定阈值的亮度值的位置时，存在该位置的用户。

公开(公告)号：JP2014023628A

公开(公告)日：2014-02-06

申请号：JP2012164924

申请日：2012-07-25

Applicant: Olympus Corp ,  オリンパス株式会社 ,  Olympus Medical Systems Corp ,  オリンパスメディカルシステムズ株式会社

Inventor： KUBO KEI ,  ISHIHARA YASUNARI ,  SHIDA YUMI ,  TAKEKOSHI SATOSHI

IPC: A61B1/00 ,  A61B1/04 ,  G02B21/06 ,  G02B21/36 ,  G02B23/24 ,  G02B23/26

CPC classification number: A61B5/0071 ,  A61B1/00009 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0646

Abstract: PROBLEM TO BE SOLVED: To provide a fluorescent observation device, capable of suitably interpreting the original characteristics such as the position and the luminance value of a high-brightness region by recognizing the reliability of characteristics of the high brightness region displayed on a current image.SOLUTION: A fluorescent observation device 1 includes: a fluorescent image generating part 62 for generating a fluorescent image G2 by photographing fluorescent light generated in an observation object X; an extract part 63 for extracting the position of a high brightness region having a luminance value equal to or higher than a predetermined threshold value in the fluorescent image G2; a storage part 64 for storing the position of the high brightness region; a detecting part 65 for detecting a variation of the physical amount which may be a factor in changing the characteristics of the high brightness region from the time when the position of the high brightness region is extracted by the extract part 63; a reliability calculating part 65 for calculating the reliability of the characteristics of the high brightness region on the basis of the detected variation; and a display image generating part 66 for generating a display image G3 to which a display mode depending on the reliability calculated by the reliability calculating part 65 is imparted at the position of the high brightness region stored in the storage part 64.

Abstract translation: 要解决的问题：提供一种能够通过识别当前图像上显示的高亮度区域的特性的可靠性来适当地解释诸如高亮度区域的位置和亮度值的原始特性的荧光观察装置。 解决方案：荧光观察装置1包括：荧光图像生成部62，用于通过拍摄在观察对象X中产生的荧光产生荧光图像G2; 提取部分63，用于在荧光图像G2中提取具有等于或高于预定阈值的亮度值的高亮度区域的位置; 用于存储高亮度区域的位置的存储部分64; 检测部65，用于检测从提取部63提取出高亮度区域的位置时可能成为改变高亮度区域的特性的因素的物理量的变化; 可靠性计算部65，用于基于检测到的变化来计算高亮度区域的特性的可靠性; 以及显示图像生成部66，用于生成显示图像G3，在存储部64中存储的高亮度区域的位置赋予显示图像G3，在显示图像G3中显示根据由可靠性计算部65计算出的可靠性的显示模式。

公开(公告)号：JP2013056001A

公开(公告)日：2013-03-28

申请号：JP2011195341

申请日：2011-09-07

Applicant: Olympus Corp ,  オリンパス株式会社 ,  Olympus Medical Systems Corp ,  オリンパスメディカルシステムズ株式会社

Inventor： ISHIHARA YASUNARI ,  SHIDA YUMI ,  KUBO KEI ,  TAKEKOSHI SATOSHI

IPC: A61B1/00 ,  A61B1/04 ,  G02B23/24

CPC classification number: G01N21/64 ,  A61B1/00009 ,  A61B1/0005 ,  A61B1/043 ,  G01N21/6456 ,  G06T5/50 ,  G06T2207/20216

Abstract: PROBLEM TO BE SOLVED: To highly precisely remove dependence on observation distance/observation angles residual in a divided image as a result of different causes, in accordance with those causes.SOLUTION: A fluorescence observation device 100 includes: a fluorescent image acquisition unit 18 and a reference image acquisition unit 17 that acquire the fluorescent image or the reference image of a subject A; a divided image generation unit 64 that divides an image based on the fluorescent image by an image based on the reference image, and generates a divided image; a display unit 20 that displays a final fluorescent image based on the divided image; a correction processing unit 65 that executes correction processing to at least one of the reference image and the fluorescent image and/or the divided image, prior to the generation of the divided image by the divided image generation unit 64 or the display of the final fluorescent image by the display unit 20; an observation condition determination unit 7 that determines observation conditions for the subject A; and a correction condition setting unit 66 that sets parameters for the correction processing by the correction processing unit 65, in accordance with the observation conditions determined by the observation condition determination unit 7.

Abstract translation: 要解决的问题：为了根据这些原因高度精确地消除由于不同原因导致的分割图像中的观察距离/观察角残差的依赖性。 解决方案：荧光观察装置100包括：获取对象A的荧光图像或参考图像的荧光图像获取单元18和参考图像获取单元17; 分割图像生成单元64，其基于基于图像的图像将基于荧光图像的图像分割，并生成分割图像; 基于分割图像显示最终荧光图像的显示单元20; 校正处理单元65，其在分割图像生成单元64生成分割图像之前，对最终荧光显示器进行显示，对参考图像和荧光图像和/或分割图像中的至少一个执行校正处理 图像通过显示单元20; 确定被检体A的观察条件的观察条件判定部7; 以及校正条件设定部66，根据由观察条件判定部7确定的观察条件，由校正处理部65设定校正处理的参数。（C）2013，JPO＆INPIT