公开(公告)号：EP0277795A2

公开(公告)日：1988-08-10

申请号：EP88300832.8

申请日：1988-02-01

Applicant: ROHM AND HAAS COMPANY

Inventor： Sivieri, Franco

IPC: C08F8/32 ,  C08F212/14 ,  A61K31/74

CPC classification number: C08F8/32 ,  C08F2800/20 ,  C08F8/44 ,  C08F8/24 ,  C08F212/08

Abstract: Known processes for preparing cholestyramine involve chloromethylating and aminating unfunctionalized styrene/divinylbenzene beads in the presence of added halogenated hydrocarbon swelling solvent, typically ethylene dichloride. The use of such halogenated swelling solvent is disadvantageous because of toxicological implications.
The present invention provides a process for preparing cholestyramine by chloromethylating and aminating unfunctionalized styrene/divinylbenzene copolymer beads, the chloromethylation and amination being conducted in the absence of added halogenated hydrocarbon swelling sovent.
Furthermore, the cholestyramine produced by the process of the invention has improved palatability when compared with cholestyramine produced by known processes.

Abstract translation: 用于制备消胆胺的已知方法包括在添加的卤代烃溶胀溶剂（通常为二氯乙烷）的存在下氯化甲基化和胺化未官能化的苯乙烯/二乙烯基苯珠。 由于毒理学影响，使用这种卤化溶胀溶剂是不利的。 本发明提供通过氯甲基化和胺化未官能化的苯乙烯/二乙烯基苯共聚物珠来制备消胆胺的方法，氯甲基化和胺化在不加入卤代烃溶胀的情况下进行。 此外，与通过已知方法制备的消胆胺相比，通过本发明的方法生产的消胆胺具有改善的适口性。

公开(公告)号：EP0223596B1

公开(公告)日：1990-05-02

申请号：EP86309001.5

申请日：1986-11-18

Applicant: ROHM AND HAAS COMPANY

Inventor： Sivieri, Franco

IPC: B01J39/00

CPC classification number: B01J49/60 ,  B01J49/05

公开(公告)号：EP0223596A2

公开(公告)日：1987-05-27

申请号：EP86309001.5

申请日：1986-11-18

Applicant: ROHM AND HAAS COMPANY

Inventor： Sivieri, Franco

IPC: B01J39/00

CPC classification number: B01J49/60 ,  B01J49/05

Abstract: A process is disclosed for washing sulfonated cation exchange resin beads to remove sulfuric acid therefrom, in which successive discrete amounts of aqueous sulfuric acid of decreasing concentration and finally a discrete amount of water are passed downwardly through a bed comprising sulfonated cation exchange resin beads and concentrated sulfuric acid.
The amount of waste sulfuric acid from this process is eliminated or substantially reduced when compared to the known stirred-reactor, batch-type process which uses large amounts of sulfuric acid of decreasing concentration and finally a large amount of water.

Abstract translation: 公开了一种用于洗涤磺化阳离子交换树脂珠以从其中除去硫酸的方法，其中连续离散量的浓度降低的硫酸水溶液和最终离散量的水向下通过包含磺化阳离子交换树脂珠和浓缩的 硫酸。 与使用大量浓度较低的硫酸以及最终大量的水的已知的搅拌反应器间歇式方法相比，该方法中的废硫酸的量被消除或显着降低。

公开(公告)号：EP0277795A3

公开(公告)日：1990-05-02

申请号：EP88300832.8

申请日：1988-02-01

Applicant: ROHM AND HAAS COMPANY

Inventor： Sivieri, Franco

IPC: C08F8/32 ,  C08F212/14 ,  A61K31/74

CPC classification number: C08F8/32 ,  C08F2800/20 ,  C08F8/44 ,  C08F8/24 ,  C08F212/08

Abstract: Known processes for preparing cholestyramine involve chloromethylating and aminating unfunctionalized styrene/divinylbenzene beads in the presence of added halogenated hydrocarbon swelling solvent, typically ethylene dichloride. The use of such halogenated swelling solvent is disadvantageous because of toxicological implications. The present invention provides a process for preparing cholestyramine by chloromethylating and aminating unfunctionalized styrene/divinylbenzene copolymer beads, the chloromethylation and amination being conducted in the absence of added halogenated hydrocarbon swelling sovent. Furthermore, the cholestyramine produced by the process of the invention has improved palatability when compared with cholestyramine produced by known processes.

公开(公告)号：EP0223596A3

公开(公告)日：1987-08-12

申请号：EP86309001

申请日：1986-11-18

Applicant: ROHM AND HAAS COMPANY

Inventor： Sivieri, Franco

IPC: B01J39/00

CPC classification number: B01J49/60 ,  B01J49/05

Abstract: A process is disclosed for washing sulfonated cation exchange resin beads to remove sulfuric acid therefrom, in which successive discrete amounts of aqueous sulfuric acid of decreasing concentration and finally a discrete amount of water are passed downwardly through a bed comprising sulfonated cation exchange resin beads and concentrated sulfuric acid. The amount of waste sulfuric acid from this process is eliminated or substantially reduced when compared to the known stirred-reactor, batch-type process which uses large amounts of sulfuric acid of decreasing concentration and finally a large amount of water.

Abstract translation: 公开了一种用于洗涤磺化阳离子交换树脂珠以从其中除去硫酸的方法，其中连续离散量的浓度降低的硫酸水溶液和最终离散量的水向下通过包含磺化阳离子交换树脂珠和浓缩的 硫酸。 与使用大量浓度较低的硫酸以及最终大量的水的已知的搅拌反应器间歇式方法相比，该方法中的废硫酸的量被消除或显着降低。