公开(公告)号：WO2016156516A3

公开(公告)日：2016-11-10

申请号：PCT/EP2016057113

申请日：2016-03-31

Applicant: SAMANTREE MEDICAL SA

Inventor： RACHET BASTIEN ,  KOSANIC DAVOR ,  SHAFFER ETIENNE

IPC: G02B21/00 ,  G01N21/64 ,  G02B21/26 ,  G02B21/34 ,  G02B21/36

CPC classification number: G01N21/77 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/4833 ,  G01N2021/6439 ,  G01N2021/6463 ,  G01N2021/7786 ,  G01N2201/0633 ,  G01N2201/068 ,  G02B21/0012 ,  G02B21/0032 ,  G02B21/004 ,  G02B21/0076 ,  G02B21/0088 ,  G02B21/16 ,  G02B21/26 ,  G02B21/34 ,  G02B21/361

Abstract: The disclosed technology brings histopathology into the operating theatre, to enable realtime intra-operative digital pathology. The disclosed technology utilizes confocal imaging devices image, in the operating theatre, "optical slices" of fresh tissue - without the need to physically slice and otherwise process the resected tissue as required by frozen section analysis (FSA). The disclosed technology, in certain embodiments, includes a simple, operating-table-side digital histology scanner, with the capability of rapidly scanning all outer margins of a tissue sample (e.g., resection lump, removed tissue mass). Using point-scanning microscopy technology, the disclosed technology, in certain embodiments, precisely scans a thin "optical section" of the resected tissue, and sends the digital image to a pathologist rather than the real tissue, thereby providing the pathologist with the opportunity to analyze the tissue intra-operatively. Thus, the disclosed technology provides digital images with similar information content as FSA, but faster and without destroying the tissue sample itself.

Abstract translation: 所公开的技术将组织病理学带入手术室，以实现手术中的实时数字病理学。 所公开的技术利用在手术室中的共焦成像装置图像，新鲜组织的“光学切片” - 而不需要根据冷冻切片分析（FSA）的要求物理切片和以其他方式处理切除的组织。 在某些实施例中，所公开的技术包括简单的手术台侧数字组织学扫描仪，其具有快速扫描组织样本的所有外边缘（例如，切除块，移除的组织块）的能力。 使用点扫描显微术技术，在某些实施例中，所公开的技术精确地扫描切除组织的薄“光学切片”，并将数字图像发送给病理学家而不是真实组织，从而为病理学家提供机会 在手术中分析组织。 因此，所公开的技术提供具有与FSA类似的信息内容的数字图像，但更快并且不破坏组织样本本身。