公开(公告)号：WO2019204634A1

公开(公告)日：2019-10-24

申请号：PCT/US2019/028165

申请日：2019-04-18

Applicant: STC. UNM

Inventor： WANDINGER-NESS, Angela ,  BURANDA, Tione ,  SIMONS, Peter ,  YOUNG, Steve

IPC: C12Q1/04 ,  C12Q1/18 ,  G01N33/483

Abstract: The present invention is directed to the discovery that RapI-GTP, Racl-GTP and Flt3-L can be used as Biomarkers for the early detection of sepsis in patients suspected of a bacterial infection which presents as sepsis or is likely to produce sepsis. In particular, the present invention is directed to methods, assays and kits which may be used to distinguish sepsis (infection) from systematic inflammatory response caused by sterile inflammation in trauma patients. The method may he used to diagnose bacteria infection and/or sepsis and monitor therapy of a patient to allow modification of treatment and/or cessation of treatment.