公开(公告)号：AU2003219972A1

公开(公告)日：2003-09-22

申请号：AU2003219972

申请日：2003-02-26

Applicant: SYMYX TECHNOLOGIES INC

Inventor： CHARMOT DOMINIQUE ,  HAJDUK DAMIAN ,  KLAERNER GERRIT ,  NGUYEN SON HOAI ,  PIOTTI MARCELO ,  LIN SHAN ,  BENOIT DIDER

IPC: G01N27/447

公开(公告)号：WO2004079338A3

公开(公告)日：2004-12-29

申请号：PCT/US2004006054

申请日：2004-02-27

Applicant: SYMYX TECHNOLOGIES INC ,  CARLSON ERIC ,  PETRO MIROSLAV ,  NGUYEN SON HOAI

Inventor： CARLSON ERIC ,  PETRO MIROSLAV ,  NGUYEN SON HOAI

IPC: G01N20060101 ,  G01N1/00 ,  G01N13/00 ,  G01N33/15

CPC classification number: C40B40/04 ,  G01N33/15 ,  Y10T436/119163 ,  Y10T436/255

Abstract: Methods and systems for determining a dissolution profile of a sample material, and for solubilization screening of a library defined by an array comprising multiple sample materials are disclosed. The methods and systems are particularly advantageous for sampling and evaluation of very small samples, and can be advantageously applied in connection with evaluation of drug candidates.

公开(公告)号：WO03021251A9

公开(公告)日：2003-10-16

申请号：PCT/US0227629

申请日：2002-08-28

Applicant: SYMYX TECHNOLOGIES INC ,  PETRO MIROSLAV ,  NGUYEN SON HOAI ,  CARLSON ERIC D

Inventor： PETRO MIROSLAV ,  NGUYEN SON HOAI ,  CARLSON ERIC D

IPC: B01D15/26 ,  B01D15/32 ,  B01D15/34 ,  B01J19/00 ,  G01N30/02 ,  G01N30/20 ,  G01N30/32 ,  G01N30/46 ,  G01N30/86 ,  G01N33/44 ,  G01N30/88

CPC classification number: G01N30/463 ,  B01D15/1878 ,  B01D15/265 ,  B01D15/325 ,  B01D15/34 ,  B01D15/424 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00286 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00389 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00704 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B01J2219/00736 ,  G01N30/02 ,  G01N30/20 ,  G01N30/46 ,  G01N30/461 ,  G01N30/8651 ,  G01N33/44 ,  G01N2030/027 ,  G01N2030/324 ,  G01N30/16

Abstract: Methods and apparatus for characterizing a polymer sample and in preferred embodiments, libraries of polymer samples, in a comprehensive, directly-coupled multi-dimensional liquid chromatography system are disclosed. The first and second dimensions are preferably high-performance liquid chromatography dimensions, such as for example, a first dimension adapted for determining composition e.g. adapted for mobile-phase gradient elution chromatography, including reverse phase chromatography, adsorption chromatography and the like), and a second dimension adapted for determining molecular weight or particle size (e.g., adapted for size exclusion chromatography, including gel permeation chromatography).

Abstract translation: 公开了在综合的直接耦合的多维液相色谱系统中用于表征聚合物样品的方法和装置，并且在优选实施方案中，聚合物样品的文库。 第一和第二维度优选是高效液相色谱尺寸，例如，适于确定组合物的第一维度。 适用于流动相梯度洗脱色谱法，包括反相色谱法，吸附色谱法等），以及适用于测定分子量或粒度的第二维度（例如适用于尺寸排阻色谱法，包括凝胶渗透色谱法）。