公开(公告)号：US09927328B2

公开(公告)日：2018-03-27

申请号：US15319723

申请日：2015-06-19

Applicant: SpinChip Diagnostics AS

Inventor： Stig Morten Borch ,  Torgeir Hamsund ,  Jostein Geir Holtlund ,  Anja Gulliksen

IPC: G01N1/10 ,  B01L3/00 ,  B03D3/00

CPC classification number: G01N1/10 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2400/0409 ,  B01L2400/0487 ,  B03D3/00 ,  G01N33/54313 ,  G01N33/54333 ,  G01N33/54366 ,  G01N2001/1006 ,  G01N2035/0449

Abstract: The present invention provides a method of separating beads in a fluidic chip comprising an internal fluid circuit through which various reactants, in which at least one of the reactants are beads, may be moved by use of centrifugal force, the method comprises the steps of: providing at least a first set of beads (8a) having a density m1 and a second set of beads (8b) having a density m2 in a section (7, 15, 18) of the fluid circuit, the section comprising at least a first outlet (16, 13, 17); providing a first liquid medium in the section, the liquid medium having a density d3, such that m1

公开(公告)号：US10408713B2

公开(公告)日：2019-09-10

申请号：US15319712

申请日：2015-06-19

Applicant: SpinChip Diagnostics AS

Inventor： Stig Morten Borch ,  Torgeir Hamsund ,  Jostein Geir Holtlund ,  Anja Gulliksen

IPC: B01L3/00 ,  B03D3/00 ,  G01N35/04 ,  G01N33/543 ,  G01N1/10

Abstract: The present invention provides a method of analyzing a sample containing an analyte to be qualitatively and/or quantitatively determined, comprising a binding step and a washing step, wherein the binding step comprises: interacting the analyte with beads having a density m1; obtaining a structure of packed beads comprising quantifiable bead complexes having a density m2; and the washing step comprises: dispersing the packed beads in a liquid medium having a density d>m2 and m1; and separating the liquid medium and the beads comprising the quantifiable bead complexes.

公开(公告)号：US10228308B2

公开(公告)日：2019-03-12

申请号：US15319717

申请日：2015-06-19

Applicant: SpinChip Diagnostics AS

Inventor： Stig Morten Borch ,  Torgeir Hamsund ,  Jostein Geir Holtlund ,  Anja Gulliksen

IPC: G01N1/10 ,  G01N33/543 ,  B01L3/00 ,  B03D3/00 ,  G01N35/04

Abstract: A method for transferring beads in a fluidic chip having an internal fluid circuit through which various reactants, including beads, may be moved by use of centrifugal force includes providing beads having a density equal to, or lower than, m1 in a section of the fluid circuit, where the section includes at least a first outlet. The method includes providing a first liquid medium having a density d2 to the section, such that d2>m1, and applying a centrifugal force such that the beads migrate in an opposite direction of the centrifugal force.